@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):198-205
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):198-205
Role of Water-based Exercise and Ginger Supplementation on Growth Factors and Strogens in Breast Cancer
ARTICLE INFO
Article Type
Original ResearchAuthors
Ghorbani Shorkaii Z. (1)Dabidi Roshan V. (*)
(*) Sport physiology Department, Physical Education & Sport Sciences Faculty, Mazandaran University, Mazandaran, Iran
(1) Exercise Physiology Department, Physical Education & Sport Sciences Faculty, Sari Islamic Azad University,, Sari, Iran
Correspondence
Article History
Received: June 30, 2013Accepted: December 26, 2013
ePublished: January 5, 2014
ABSTRACT
Aims
The aim of this study was to determine the individual and concomitant effect of waterbased
exercise and oral Zingiber officinale supplement on changes in growth factors and
estrogen in overweight women with breast cancer.
Materials & Methods In a semi-experimental study, 40 obese women diagnosed with breast cancer (76±9kg, fat mass 41.8±4%) participated. Subjects were randomly assigned into groups; placebo, water-based exercise, Zingiber and water-based exercise+Zingiber groups. Subjects in the Zingiber group and combined group orally received 4 capsules contained 750mg of zingiber flour for 6 weeks. The water-based exercise program was conducted at a progressive intensity and time, ranged from 50 to 75% of heart rate reserve, for 6 weeks. Fasting blood sampling was collected at the pretest and post-test.
Findings Although, the Zingiber and/or the water-base exercise resulted in a reduction in IGF-1 and estrogen levels and an increase in IGFBP-3 levels, changes in the index following the combined intervention (exercise in water+Ginger supplements) were more pronounced compared with pre-test and the control group. However, there was the significant difference only in IGFBP-3 levels between water-base exercise and Zingiber supplementation groups.
Conclusion There is a protective effect of the non-drug strategies such as exercise in water and anti-inflammatory herbal factors in the pathogenesis of growth and metabolic responses in overweight women diagnosed with breast cancer.
Materials & Methods In a semi-experimental study, 40 obese women diagnosed with breast cancer (76±9kg, fat mass 41.8±4%) participated. Subjects were randomly assigned into groups; placebo, water-based exercise, Zingiber and water-based exercise+Zingiber groups. Subjects in the Zingiber group and combined group orally received 4 capsules contained 750mg of zingiber flour for 6 weeks. The water-based exercise program was conducted at a progressive intensity and time, ranged from 50 to 75% of heart rate reserve, for 6 weeks. Fasting blood sampling was collected at the pretest and post-test.
Findings Although, the Zingiber and/or the water-base exercise resulted in a reduction in IGF-1 and estrogen levels and an increase in IGFBP-3 levels, changes in the index following the combined intervention (exercise in water+Ginger supplements) were more pronounced compared with pre-test and the control group. However, there was the significant difference only in IGFBP-3 levels between water-base exercise and Zingiber supplementation groups.
Conclusion There is a protective effect of the non-drug strategies such as exercise in water and anti-inflammatory herbal factors in the pathogenesis of growth and metabolic responses in overweight women diagnosed with breast cancer.
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