@2024 Afarand., IRAN
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2019;3(1):9-12
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2019;3(1):9-12
Evaluation the success rate of treatment failure in patients with unexplained repeated IVF treatments immunization with lymphocytes (LIT) methods
ARTICLE INFO
Article Type
Original ResearchAuthors
Saremi A. (*1)Golnavaz M. (2)
Pooladi A. (1)
Sanaye Naderi M. (2)
Mohammad Aliha F. (2)
Hakkak N. (2)
(*1) “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women’s Hospital, Tehran, Iran
(2) Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran
Correspondence
Article History
Received: July 4, 2017Accepted: October 10, 2017
ePublished: January 4, 2019
ABSTRACT
Aims
The repeated implantation failure (RIF) with unknown cause is one of the important problems in the IVF treatment process. Due to the importance of immunological factors, it seems that modulating the immune system through methods such as lymphocyte immunotherapy (LIT) is an appropriate strategy for embryo receptivity. The objective of this study was to determine the success rate of LIT in patients with a history of frequent IVF failure with unknown cause.
Materials & Methods This interventional; non-experimental study conducted on 61 patients (infertile) with 2 or more IVF failure, in Sarem women’s hospital (Tehran, Iran) over a period of 2 years from the beginning of 2010 to 2012. The women were selected for LIT that their cross-match test was negative for antipaternal cytotoxic antibody (APCA). Data were analyzed using SPSS 13 software.
Findings The mean numbers of transferred embryos were 3.17 and 1.5 for fresh and frozen embryos, respectively. The pregnancy rate per LIT cycle was 31.1%. The success rate in terms of full-term births per LIT cycle was generally estimated as 26.23%. There was no significant relationship between the positive results of β-HCG test with the duration of infertility, number of acquired follicles, frozen embryo transfer (FET) or embryo transfer (ET).
Conclusion Lymphocyte immunotherapy can be used as a suitable treatment option for patients with frequent failure in IVF with unknown cause
Materials & Methods This interventional; non-experimental study conducted on 61 patients (infertile) with 2 or more IVF failure, in Sarem women’s hospital (Tehran, Iran) over a period of 2 years from the beginning of 2010 to 2012. The women were selected for LIT that their cross-match test was negative for antipaternal cytotoxic antibody (APCA). Data were analyzed using SPSS 13 software.
Findings The mean numbers of transferred embryos were 3.17 and 1.5 for fresh and frozen embryos, respectively. The pregnancy rate per LIT cycle was 31.1%. The success rate in terms of full-term births per LIT cycle was generally estimated as 26.23%. There was no significant relationship between the positive results of β-HCG test with the duration of infertility, number of acquired follicles, frozen embryo transfer (FET) or embryo transfer (ET).
Conclusion Lymphocyte immunotherapy can be used as a suitable treatment option for patients with frequent failure in IVF with unknown cause
CITATION LINKS
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[3] Schröder AK, Katalinic A, Diedrich K, Ludwig M. Cumulative pregnancy rates and drop-out rates in a German IVF programme: 4102 cycles in 2130 patients. Reprod Biomed Online. 2004;8(5):600-6.
[4]Witsenburg C, Dieben S, Van der Westerlaken L, Verburg H, Naaktgeboren N. Cumulative live birth rates in cohorts of patients treated with in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril. 2005;84(1):99-107.
[5]Sharma V, Allgar V, Rajkhowa M. Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility. Fertil Steril. 2002;78(1):40-6.
[6]Zarei S, Arefi S, Zarnani AH, Mohammadzadeh A, Ghaffari M, Jeddi-Tehrani M. Repeated implantation failures following embryo transfer. J Reprod Infertil. 2008;8(4):380-96.
[7]Margalioth E, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod. 2006;21(12):3036-43.
[8]Daya S. Life table (survival) analysis to generate cumulative pregnancy rates in assisted reproduction: are we overestimating our success rates?. Hum Reprod. 2005;20(5):1135-43.
[9]Bansal A, Bajardeen B, Thum MY. The basis and value of currently used immunomodulatory therapies in recurrent miscarriage. J Reprod Immunol. 2012;93(1):41-51.
[10]Putowski L, Darmochwal-Kolarz D, Rolinski J, Oleszczuk J, Jakowicki J. The immunological profile of infertile women after repeated IVF failure (preliminary study). Eur J Obstet Gynecol Reprod Biol. 2004;112(2):192-6.
[11]Beer AE, Quebbeman JF, Ayers JW, Haines RF. Major histocompatibility complex antigens, maternal and paternal immune responses, and chronic habitual abortions in humans. Am Obstet Gynecol. 1981;141(8):987-99.
[12]Check JH, Liss J, Check ML, Diantonio A, Choe JK, Graziano V. Leukocyte immunotherapy improves live delivery rates following embryo transfer in women with at least two previous failures: A retrospective review. Clin Exp Obstet Gyncol. 2005;32(2):85-8.
[13]Check JH, Liss JR, Check ML, Diantonio A, Duroseau M. Lymphocyte immunotherapy can improve pregnancy outcome following embryo transfer (ET) in patients failing to conceive after two previous ET. Clin Exp Obstet Gynecol. 2005;32(1):21-2.
[14]Chaichian S, Shoaee S, Saremi A, Pedar S, Firouzi F. Factors Influencing Success Rate of Leukocyte Immunization and Anti‐paternal Antibodies in Spontaneous Recurrent Miscarriage. Am J Reprod Immunol. 2007;57(3):169-76.
[2]Osmanagaoglu K, Tournaye H, Camus M, Vandervorst M, Van Steirteghem A, Devroey P. Cumulative delivery rates after intracytoplasmic sperm injection: 5 year follow-up of 498 patients. Hum Reprod. 1999;14(10):2651-5.
[3] Schröder AK, Katalinic A, Diedrich K, Ludwig M. Cumulative pregnancy rates and drop-out rates in a German IVF programme: 4102 cycles in 2130 patients. Reprod Biomed Online. 2004;8(5):600-6.
[4]Witsenburg C, Dieben S, Van der Westerlaken L, Verburg H, Naaktgeboren N. Cumulative live birth rates in cohorts of patients treated with in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril. 2005;84(1):99-107.
[5]Sharma V, Allgar V, Rajkhowa M. Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility. Fertil Steril. 2002;78(1):40-6.
[6]Zarei S, Arefi S, Zarnani AH, Mohammadzadeh A, Ghaffari M, Jeddi-Tehrani M. Repeated implantation failures following embryo transfer. J Reprod Infertil. 2008;8(4):380-96.
[7]Margalioth E, Ben-Chetrit A, Gal M, Eldar-Geva T. Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod. 2006;21(12):3036-43.
[8]Daya S. Life table (survival) analysis to generate cumulative pregnancy rates in assisted reproduction: are we overestimating our success rates?. Hum Reprod. 2005;20(5):1135-43.
[9]Bansal A, Bajardeen B, Thum MY. The basis and value of currently used immunomodulatory therapies in recurrent miscarriage. J Reprod Immunol. 2012;93(1):41-51.
[10]Putowski L, Darmochwal-Kolarz D, Rolinski J, Oleszczuk J, Jakowicki J. The immunological profile of infertile women after repeated IVF failure (preliminary study). Eur J Obstet Gynecol Reprod Biol. 2004;112(2):192-6.
[11]Beer AE, Quebbeman JF, Ayers JW, Haines RF. Major histocompatibility complex antigens, maternal and paternal immune responses, and chronic habitual abortions in humans. Am Obstet Gynecol. 1981;141(8):987-99.
[12]Check JH, Liss J, Check ML, Diantonio A, Choe JK, Graziano V. Leukocyte immunotherapy improves live delivery rates following embryo transfer in women with at least two previous failures: A retrospective review. Clin Exp Obstet Gyncol. 2005;32(2):85-8.
[13]Check JH, Liss JR, Check ML, Diantonio A, Duroseau M. Lymphocyte immunotherapy can improve pregnancy outcome following embryo transfer (ET) in patients failing to conceive after two previous ET. Clin Exp Obstet Gynecol. 2005;32(1):21-2.
[14]Chaichian S, Shoaee S, Saremi A, Pedar S, Firouzi F. Factors Influencing Success Rate of Leukocyte Immunization and Anti‐paternal Antibodies in Spontaneous Recurrent Miscarriage. Am J Reprod Immunol. 2007;57(3):169-76.