@2025 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):218-223
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):218-223
Effect of Hydroalcoholic Extract of Zataria multiflora Bioss on Serum Lipids Levels in High Cholesterol Diet Fed Rats
ARTICLE INFO
Article Type
Original ResearchAuthors
Zarei M.A. (*)Eftekhary H. (1)
Aqhababa H. (1)
(*) Biology Department, Basic Sciences Faculty, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
(1) Biology Department, Basic Sciences Faculty, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Correspondence
Article History
Received: June 12, 2013Accepted: December 26, 2013
ePublished: January 5, 2014
ABSTRACT
Aims
The aim of this study was to compare the effect of alcoholic extract of Zataria multiflora
with atorvastatin on blood lipid profile.
Materials & Methods 56 Wistar male rats were divided into 7 groups each of which included 8 animals which were treated for 4 weeks with 7 dieting systems. The groups were as follows. Group 1 (Control I): Normal diet and unlimited water and food; Group 2: Daily normal food + 3g/kg corn oil as a means for cholesterol; Group 3 (Control II, hypercholestrolemia): Usual daily food + 2g/kg cholesterol dissolved in 3g/kg corn oil; Group 4: Treated like group 3 but with increased 10 mg/kg Atorvastatin as an anti-fat; Groups 5, 6, and 7: Treated like group 3 but received 100, 200 & 300 mg/kg Z.M. extract, respectively. After 4 weeks, and at the end of the experiment, following 14 hours of starvation, the rats got anesthesia with chloroform and the blood sample was taken from the heart. The blood was collected in test tubes and transferred to the laboratory. After determining the factors of TG, TC, LDL, VLDL & HDL, the data were analyzed with SPSS software employing ANOVA (F-test).
Findings It seemed that corn oil and cholesterol had increased the blood fat factors significantly. As it was expected, Group 4 showed a reduction in these factors; Groups 5, 6 & 7, which received Z.M. extract, decreased the blood fat factors significantly, except that HDL increased significantly.
Conclusion The extract of Zataria multiflora has anti hyperlipidemia effects and can be used as an herbal medicine in controlling the blood cholesterol.
Materials & Methods 56 Wistar male rats were divided into 7 groups each of which included 8 animals which were treated for 4 weeks with 7 dieting systems. The groups were as follows. Group 1 (Control I): Normal diet and unlimited water and food; Group 2: Daily normal food + 3g/kg corn oil as a means for cholesterol; Group 3 (Control II, hypercholestrolemia): Usual daily food + 2g/kg cholesterol dissolved in 3g/kg corn oil; Group 4: Treated like group 3 but with increased 10 mg/kg Atorvastatin as an anti-fat; Groups 5, 6, and 7: Treated like group 3 but received 100, 200 & 300 mg/kg Z.M. extract, respectively. After 4 weeks, and at the end of the experiment, following 14 hours of starvation, the rats got anesthesia with chloroform and the blood sample was taken from the heart. The blood was collected in test tubes and transferred to the laboratory. After determining the factors of TG, TC, LDL, VLDL & HDL, the data were analyzed with SPSS software employing ANOVA (F-test).
Findings It seemed that corn oil and cholesterol had increased the blood fat factors significantly. As it was expected, Group 4 showed a reduction in these factors; Groups 5, 6 & 7, which received Z.M. extract, decreased the blood fat factors significantly, except that HDL increased significantly.
Conclusion The extract of Zataria multiflora has anti hyperlipidemia effects and can be used as an herbal medicine in controlling the blood cholesterol.
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