@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2013;19(3):167-171
ISSN: 2252-0805 The Horizon of Medical Sciences 2013;19(3):167-171
Comparison of Ferritin Level in Diabetic and Non-Diabetic Patients with Acute Myocardial Infarction
ARTICLE INFO
Article Type
Original ResearchAuthors
Sharifnia S. H. (*)Haghdoost A. A. (1)
Soleymani M. A. (2)
Taghipour B. (3)
Alayi B. (4)
(*) Medical Surgical Nursing Department, Nursing & Midwifery Faculty of Amol, Mazandaran University of Medical Sciences, Sari, Iran
(1) Modeling in Health Research Center, Insititute of Future Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
(2) Medical Surgical Nursing Department, Nursing & Midwifery Faculty, Qazvin University of Medical Sciences, Qazvin, Iran
(3) Student Research Committee, Nursing & Midwifery Faculty of Amol, Mazandaran University of Medical Sciences, Sari, Iran
(4) Department of Laboratory Sciences, Paramedical Faculty of Amol, Mazandaran University of Medical Sciences, Sari, Iran
Correspondence
Article History
Received: November 27, 2012Accepted: August 13, 2013
ePublished: October 3, 2013
ABSTRACT
Aims
Diabetes type II is one of the most common disorders of endocrine system in the world. Recently one hypothesis has been proposed about the role of increased ferritin in occurrence of diabetes type II. The present study investigated serum ferritin levels in diabetic and non-diabetic patients with myocardial infarction.
Materials & Methods In this cross-sectional study on patients in the CCU ward of Imam Reza Hospital of Amol in 2011, 50 patients with diabetes type II and 50 non-diabetic patients amongst patients with acute myocardial infarction were entered in study purposefully. Cell Blood Count, Triglyceride, Cholesterol, LDL, HDL, Ferritin, Iron and TIBC were measured. Data analysis was performed by Chi-square, independent T, one sample T and logistic regression tests using SPSS 20 software.
Findings The risk of diabetes in women was 5.56 times more than men. The difference of mean serum ferritin levels between diabetic (170.60±126.36mg/dl) and non-diabetic (164.40±113.42mg/dl) was not statistically significant (p=0.7). But the difference of mean serum Iron levels between diabetic (87.58±35.72mg/dl) and nondiabetic(60.44±20.38mg/dl) patients was statistically significant (p<0.0001).
Conclusion There was no relation between ferritin level of patients with diabetes type II and occurrence of acute myocardial infarction.
Materials & Methods In this cross-sectional study on patients in the CCU ward of Imam Reza Hospital of Amol in 2011, 50 patients with diabetes type II and 50 non-diabetic patients amongst patients with acute myocardial infarction were entered in study purposefully. Cell Blood Count, Triglyceride, Cholesterol, LDL, HDL, Ferritin, Iron and TIBC were measured. Data analysis was performed by Chi-square, independent T, one sample T and logistic regression tests using SPSS 20 software.
Findings The risk of diabetes in women was 5.56 times more than men. The difference of mean serum ferritin levels between diabetic (170.60±126.36mg/dl) and non-diabetic (164.40±113.42mg/dl) was not statistically significant (p=0.7). But the difference of mean serum Iron levels between diabetic (87.58±35.72mg/dl) and nondiabetic(60.44±20.38mg/dl) patients was statistically significant (p<0.0001).
Conclusion There was no relation between ferritin level of patients with diabetes type II and occurrence of acute myocardial infarction.
CITATION LINKS
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[3] Nasiri Amiri F, Basirat Z, Sharbatdaran M, Pour Amir M, Hajian K, Omidvar SH. Compression of hemoglobin concentration and body iron stores in normal pregnancy and gestational diabetes mellitus. Babol Univ Med Sci J. 2011;13(2):32-8. [Persian]
[4] Wrede CE, Buettner R, Bollheimer LC, Scholmerich J, Palitzsch KD, Hellerbrand C. Association between serum ferritin and the insulin resistance syndrome in a representative population. Eur J Endocrinol. 2006;154(2):333-40.
[5] Mainous AG, Diaz VA. Relation of serum ferritin level to cardiovascular fitness among young men. Am J Cardiol. 2009;10(3):115-8.
[6] Bae S, Le TD, Karen PS, Steven NB, Jame RM. Association between serum ferritin, cardiorespiratory fitness and risk of type 2 diabetes: Aerobics center longitudinal study. Australia; 18th World IMACS/MODSIM Congress, 2009.
[7] Zakarya A. The level of ferritin in diabetic and nondiabetic patients with non-ischaemic cardiomyopathy. Egypt: Ain-Shams University; 2008.
[8] Lee B, Kim K, Kim Yd. Association of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean national health and nutrition examination survey. Metabolism. 2011;19(2):123-30.
[9] Khosoosi Niaki MR, Salehi Omran MT, Jalali F, Ashrafian H. Serum ferritin and acute myocardial infarction. Ofogh-e-Danesh J. 2005;11(1):48-52.
[10] Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation. 1992;86:803-11.
[11] arari AM, Mohammed Farag AMM, Al-Attar HA, Mohan Pathak R. Ferritin levels and erythrocyte lipid peroxidation in acute myocardial infarction in diabetic patients. Jamahiriya Med J. 2010;10(2):101-5.
[12] Galan P, Noisette N, Estaquio C, Czernichow S, Mennen L, Renversez JC. Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: A prospective analysis in the SU.VI.MAX (Supplementation en VItamines et mineraux AntioXydants) cohort. Public Health Nutr. 2006;9(1):70-4.
[13] Swaminathan S, Alam M. The role of iron in diabetesand its complications. Diabetes Care. 2007;30(7):1926-33.
[14] Jiang R, Joann E. Body iron storees in relation to risk of type 2 diabetes in apparently healthy women. JAMA. 2004;29(1):711-7.
[15] Jehn ML, Guallar E, Clark JM, Couper D, Duncan BB, Ballantyne CM. A prospective study of plasma ferritin level and incident diabetes: The atherosclerosis risk in communities study. Am J Epidemiol. 2007;165(9):1047-54.
[16] Mert M, Koekmaz M, Temizel M, Acar M. The level of ferritin in diabetic and nondiabetic patients with acute myocardial infarction. Turk J Med Sci. 2005;35(1):25-34.
[17] Alam Samimi M, Emadi M, Azami M, Najafiyan J, Jamshidiyan M. Study of the relation between serum ferritin levels and coronary artery disease. Kowsar Med J. 2008;13(3):245-52.
[18] Devon HA, Catherine J, Amy L, Moshe S. Synmptoms across the continuum of acute coronary syndromes: Differences between women and men. Am J Crit Care. 2008;17(1):14-25.
[19] Funk M, Naum JB, Milner KA, Chyun D. Presentation and symptom predictors of coronary heart disease in patients with and without diabetes. AM J Emerg Med. 2001;19(6):482-7.
[20] Zhang Y, Howard BV, Cowan LD, Yeh J, Schaefer CF, Wild RA. The effect of estrogen use on levels of glucose and insulin and the risk of type2 diabetes in American Indian postmenopausal women. Diabetes Care. 2002;25(3):500-4.
[21]Scholl O. Iron status during pregnancy: Setting the stage for mother and infant. Am J Clin Nutr. 2005;81(5):1218-22.
[2] Forouhi NG, Harding AH, Allison M, Sandhu MS, Welch A, Luben R. Elevated serum ferritin levels predict new-onset type 2 diabetes: Results from the EPIC-norfolk prospective study. Diabetologia. 2007;50(5):949-56.
[3] Nasiri Amiri F, Basirat Z, Sharbatdaran M, Pour Amir M, Hajian K, Omidvar SH. Compression of hemoglobin concentration and body iron stores in normal pregnancy and gestational diabetes mellitus. Babol Univ Med Sci J. 2011;13(2):32-8. [Persian]
[4] Wrede CE, Buettner R, Bollheimer LC, Scholmerich J, Palitzsch KD, Hellerbrand C. Association between serum ferritin and the insulin resistance syndrome in a representative population. Eur J Endocrinol. 2006;154(2):333-40.
[5] Mainous AG, Diaz VA. Relation of serum ferritin level to cardiovascular fitness among young men. Am J Cardiol. 2009;10(3):115-8.
[6] Bae S, Le TD, Karen PS, Steven NB, Jame RM. Association between serum ferritin, cardiorespiratory fitness and risk of type 2 diabetes: Aerobics center longitudinal study. Australia; 18th World IMACS/MODSIM Congress, 2009.
[7] Zakarya A. The level of ferritin in diabetic and nondiabetic patients with non-ischaemic cardiomyopathy. Egypt: Ain-Shams University; 2008.
[8] Lee B, Kim K, Kim Yd. Association of serum ferritin with metabolic syndrome and diabetes mellitus in the South Korean general population according to the Korean national health and nutrition examination survey. Metabolism. 2011;19(2):123-30.
[9] Khosoosi Niaki MR, Salehi Omran MT, Jalali F, Ashrafian H. Serum ferritin and acute myocardial infarction. Ofogh-e-Danesh J. 2005;11(1):48-52.
[10] Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation. 1992;86:803-11.
[11] arari AM, Mohammed Farag AMM, Al-Attar HA, Mohan Pathak R. Ferritin levels and erythrocyte lipid peroxidation in acute myocardial infarction in diabetic patients. Jamahiriya Med J. 2010;10(2):101-5.
[12] Galan P, Noisette N, Estaquio C, Czernichow S, Mennen L, Renversez JC. Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: A prospective analysis in the SU.VI.MAX (Supplementation en VItamines et mineraux AntioXydants) cohort. Public Health Nutr. 2006;9(1):70-4.
[13] Swaminathan S, Alam M. The role of iron in diabetesand its complications. Diabetes Care. 2007;30(7):1926-33.
[14] Jiang R, Joann E. Body iron storees in relation to risk of type 2 diabetes in apparently healthy women. JAMA. 2004;29(1):711-7.
[15] Jehn ML, Guallar E, Clark JM, Couper D, Duncan BB, Ballantyne CM. A prospective study of plasma ferritin level and incident diabetes: The atherosclerosis risk in communities study. Am J Epidemiol. 2007;165(9):1047-54.
[16] Mert M, Koekmaz M, Temizel M, Acar M. The level of ferritin in diabetic and nondiabetic patients with acute myocardial infarction. Turk J Med Sci. 2005;35(1):25-34.
[17] Alam Samimi M, Emadi M, Azami M, Najafiyan J, Jamshidiyan M. Study of the relation between serum ferritin levels and coronary artery disease. Kowsar Med J. 2008;13(3):245-52.
[18] Devon HA, Catherine J, Amy L, Moshe S. Synmptoms across the continuum of acute coronary syndromes: Differences between women and men. Am J Crit Care. 2008;17(1):14-25.
[19] Funk M, Naum JB, Milner KA, Chyun D. Presentation and symptom predictors of coronary heart disease in patients with and without diabetes. AM J Emerg Med. 2001;19(6):482-7.
[20] Zhang Y, Howard BV, Cowan LD, Yeh J, Schaefer CF, Wild RA. The effect of estrogen use on levels of glucose and insulin and the risk of type2 diabetes in American Indian postmenopausal women. Diabetes Care. 2002;25(3):500-4.
[21]Scholl O. Iron status during pregnancy: Setting the stage for mother and infant. Am J Clin Nutr. 2005;81(5):1218-22.