@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2013;19(2):77-82
ISSN: 2252-0805 The Horizon of Medical Sciences 2013;19(2):77-82
Effect of Fitana Herbal Compound on Weight and Blood Lipid Profile of Male Wistar Rats
ARTICLE INFO
Article Type
Original ResearchAuthors
Hassanzadeh Taheri M. M. (1)Hassanpour Fard M. (*)
Abolghasemi A. (2)
Ahmadi N. (2)
Hosseini M. (3)
(*) Department of Physiology & Pharmacology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
(1) Department of Anatomy, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
(2) Department of Laboratory Sciences, Paramedicine Faculty, Birjand University of Medical Sciences, Birjand, Iran
(3) Department of Anatomy, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Correspondence
Address: Department of Physiology & Pharmacology, Faculty of Medicine, Birjand University of Medical Sciences, Ghaffari Street, Birjand, South Khorasan, Iran.Phone: +985618825368
Fax: +985614433004
mhassanpour61@yahoo.com
Article History
Received: August 25, 2012Accepted: June 18, 2013
ePublished: June 25, 2013
ABSTRACT
Aims
Obesity is one of the most common problems in societies which can induce many diseases. Some methods have been suggested and are used for the treatment of obesity which herbal therapy is one of them. The aim of this study was to determine the effect of Fitana herbal compound as an anti-obesity product on weight and blood lipid profile in male Wistar rats.
Materials & Methods In this study 40 male Wistar rats with the average weight of 280-300g were used. The rats were divided into 5 groups as experimental I (200mg/kg of aqueous extract of Fitana), and experimental II (400mg/kg of aqueous extract of Fitana), experimental III(200mg/kg of alcoholic extract of Fitana), control I (negative control) and control II (5mg/kg of Orlistat). Data were analyzed by SPSS 11.5 using Tukey and ANOVA tests.
Findings There was no significant difference in the mean of weight and BMI among experimental groups. Triglyceride level was only decreased significantly in experimental group II (62.62±9.94; p=0.0014) and III (62.12±12.02; p=0.011) in comparison with negative control group (84.37±13.51mg/dl).
Conclusion Oral consumption of Fitana herbal compound can reduce triglyceride level in blood.
Materials & Methods In this study 40 male Wistar rats with the average weight of 280-300g were used. The rats were divided into 5 groups as experimental I (200mg/kg of aqueous extract of Fitana), and experimental II (400mg/kg of aqueous extract of Fitana), experimental III(200mg/kg of alcoholic extract of Fitana), control I (negative control) and control II (5mg/kg of Orlistat). Data were analyzed by SPSS 11.5 using Tukey and ANOVA tests.
Findings There was no significant difference in the mean of weight and BMI among experimental groups. Triglyceride level was only decreased significantly in experimental group II (62.62±9.94; p=0.0014) and III (62.12±12.02; p=0.011) in comparison with negative control group (84.37±13.51mg/dl).
Conclusion Oral consumption of Fitana herbal compound can reduce triglyceride level in blood.
CITATION LINKS
[1] Akiyama T, Tachibana I, Shirohara H, Watanabe N, Otsuki M. High-fat hypercaloric diet induces obesity, glucose intolerance and hyperlipidemia in normal adult male Wistar rat. Diabetes Res Clin Pract. 1996;31(1-3):27-35.
[2] Altunkayank Z. Effects of high fat diet induced obesity on female rat livers. Eur J Gen Med. 2005;2(3):100-9.
[3] James PT, Rigby N, Leach R. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil. 2004;11(1):3-8.
[4] Abu-Abid S, Szold A, Klausner J. Obesity and cancer. J Med. 2002;33(1-4):73-86.
[5] Pi-Sunyer FX. The medical risks of obesity. Obes Surg. 2002;12(1):6-11.
[6] Yamamoto M, Shimura S, Itoh Y, Ohsaka T, Egawa M, Inoue S. Anti-obesity effects of lipase inhibitor CT-II: An extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obes. 2000;24(6):758-764.
[7] Garugouri Y, Julien R, Pieroni G, Verger R, Sarda L. Studies on the inhibition of pancreatic and microbial lipases by soybean proteins. J Lipid Res. 1984;25:1214-21.
[8] Satouchi K, Matsushita S. Purification and properties of a lipase inhibiting protein from soybean cotyledons. Agric Biol Chem. 1976;40:889-97.
[9] Vasudeva N, Yadav N, Sharma SK. Natural products: A safest approach for obesity. Chin J Integr Med. 2012;18(6):473-80.
[10] Kamali SH, Khalaj AR, Hasani-Ranjbar S, Esfehani MM, Kamalinejad M, Soheil O, et al. Efficacy of Itrifal Saghir: A combination of three medicinal plants in the treatment of obesity: A randomized controlled trial. Daru J. 2012;20(1):33.
[11] Khalili H, Gholami Kh, Dashti S, Ramezani R. Comparison of gemfibrozil and lipid effects on reduction of serum levels of triglyceride and cholesterol in hyperlipedimic patients. Kerman Univ Med Sci J. 2006;14(1):19-24.
[12] Ni H, Simile C, Hardy AM. Utilization of complementary and alternative medicine by United States adults: Results from the 1999 national health interview survey. Med Care. 2002;40(4):353-8.
[13] Morton JF. Herbs and species. New York: Golden Press; 1976.
[14] Bailer J, Aichinger T, Hackl G, Hueber KD, Dachler M. Essential oil content and composition in commercially available dill cultivars in comparison to caraway. Ind Crops Prod. 2001;14:229-39.
[15] Matsumura T, Ishikawa T, Kitajima J. Water-soluble constituents of caraway: Aromatic compound, aromatic compound glucoside and glucides. Phytochemistry. 2002;61:455-9.
[16] Salehi MH. Medicinal plants and plant therapy. 2nd ed. Tehran: Teymoorzadeh Publication; 2008. [Persian]
[17] Amin GR. The most common of Iranian traditional medicinal plants. 2nd ed. Tehran: Teymoorzadeh Publication; 2008. [Persian]
[18] Asif HM, Akram M, Usmanghani K, Akhtar N, Shah PA, Uzair M, et al. Monograph of Apium graveolens Linn. J Med Plant Res. 2011;5(8):1494-6.
[19] Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascene. Iran J Basic Med Sci. 2011;14(4):295-307.
[20] Hongratanaworakit T. Relaxing effect of rose oil on humans. Nat Prod Commun. 2009;4(2):291-6.
[21] Kamaleeswari M, Nalini N. Dose-response efficacy of Carum carvi on tissue lipid peroxidation and antioxidant profile in rat colon carcinogenesis. J Pharmacol. 2006;58:1121-30.
[22] Haidari F, SeyedSadjadi N, Taha-Jalali M, Mohammad- Shahi M. The effect of oral administration of carumcarvi on weight, serum glucose and lipid profile in streptozotocininduced diabetic rats. Saudi Med J. 2011;32(7):695-700.
[23]Mazumder PM, Farswan M, Parcha V. Effect of an isolated active compound (Cg-1) of cassia glauca leaf on blood glucose, lipid profile and atherogenic index in diabetic rats. Indian J Pharmacol. 2009;41(14):182-6.
[24] Vijayaraj P, Muthukumar K, Sabarirajan J, Nachiappan V. Antihyperlipidemic activity of cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats. Exp Toxicol Pathol. 2013;65(1-2):135-41.
[25] Shanmugasundaram R, Kalpana Devi V, TresinaSoris P, Maruthupandian A, Mohan VR. Antidiabetic, antihyperlipidaemic and antioxidant activity of Senna auriculata (L.) Roxb. leaves in alloxan induced diabetic rats. Int J Pharm Tech Res. 2011;3(2):747-56.
[26] Gholamhoseinian A, Shahouzehi B, Sharifi-Far F. Inhibitory activity of some plant methanol extracts on 3- hydroxy-3-methylglutaryl coenzyme A reductase. Int J Pharm. 2010;6:705-11.
[27] Gholamhoseinian A, Fallah H, Sharififar F. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on α-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine. 2009;16(10):935-41.
[28] Gholamhoseinian A, Shahouzehi B, SharififarF. Inhibitory effect of some plant extract on pancreatic lipase. Int J Pharm. 2010;6(1):18-24.
[29] Mansi K, Abushoffa AM, Disi A, Aburjai T. Hypolipidemic effects of seed extract of celery (Apium graveolens) in rats. Phcog Mag. 2009;5(20):301-5.
[2] Altunkayank Z. Effects of high fat diet induced obesity on female rat livers. Eur J Gen Med. 2005;2(3):100-9.
[3] James PT, Rigby N, Leach R. The obesity epidemic, metabolic syndrome and future prevention strategies. Eur J Cardiovasc Prev Rehabil. 2004;11(1):3-8.
[4] Abu-Abid S, Szold A, Klausner J. Obesity and cancer. J Med. 2002;33(1-4):73-86.
[5] Pi-Sunyer FX. The medical risks of obesity. Obes Surg. 2002;12(1):6-11.
[6] Yamamoto M, Shimura S, Itoh Y, Ohsaka T, Egawa M, Inoue S. Anti-obesity effects of lipase inhibitor CT-II: An extract from edible herbs, Nomame Herba, on rats fed a high-fat diet. Int J Obes. 2000;24(6):758-764.
[7] Garugouri Y, Julien R, Pieroni G, Verger R, Sarda L. Studies on the inhibition of pancreatic and microbial lipases by soybean proteins. J Lipid Res. 1984;25:1214-21.
[8] Satouchi K, Matsushita S. Purification and properties of a lipase inhibiting protein from soybean cotyledons. Agric Biol Chem. 1976;40:889-97.
[9] Vasudeva N, Yadav N, Sharma SK. Natural products: A safest approach for obesity. Chin J Integr Med. 2012;18(6):473-80.
[10] Kamali SH, Khalaj AR, Hasani-Ranjbar S, Esfehani MM, Kamalinejad M, Soheil O, et al. Efficacy of Itrifal Saghir: A combination of three medicinal plants in the treatment of obesity: A randomized controlled trial. Daru J. 2012;20(1):33.
[11] Khalili H, Gholami Kh, Dashti S, Ramezani R. Comparison of gemfibrozil and lipid effects on reduction of serum levels of triglyceride and cholesterol in hyperlipedimic patients. Kerman Univ Med Sci J. 2006;14(1):19-24.
[12] Ni H, Simile C, Hardy AM. Utilization of complementary and alternative medicine by United States adults: Results from the 1999 national health interview survey. Med Care. 2002;40(4):353-8.
[13] Morton JF. Herbs and species. New York: Golden Press; 1976.
[14] Bailer J, Aichinger T, Hackl G, Hueber KD, Dachler M. Essential oil content and composition in commercially available dill cultivars in comparison to caraway. Ind Crops Prod. 2001;14:229-39.
[15] Matsumura T, Ishikawa T, Kitajima J. Water-soluble constituents of caraway: Aromatic compound, aromatic compound glucoside and glucides. Phytochemistry. 2002;61:455-9.
[16] Salehi MH. Medicinal plants and plant therapy. 2nd ed. Tehran: Teymoorzadeh Publication; 2008. [Persian]
[17] Amin GR. The most common of Iranian traditional medicinal plants. 2nd ed. Tehran: Teymoorzadeh Publication; 2008. [Persian]
[18] Asif HM, Akram M, Usmanghani K, Akhtar N, Shah PA, Uzair M, et al. Monograph of Apium graveolens Linn. J Med Plant Res. 2011;5(8):1494-6.
[19] Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascene. Iran J Basic Med Sci. 2011;14(4):295-307.
[20] Hongratanaworakit T. Relaxing effect of rose oil on humans. Nat Prod Commun. 2009;4(2):291-6.
[21] Kamaleeswari M, Nalini N. Dose-response efficacy of Carum carvi on tissue lipid peroxidation and antioxidant profile in rat colon carcinogenesis. J Pharmacol. 2006;58:1121-30.
[22] Haidari F, SeyedSadjadi N, Taha-Jalali M, Mohammad- Shahi M. The effect of oral administration of carumcarvi on weight, serum glucose and lipid profile in streptozotocininduced diabetic rats. Saudi Med J. 2011;32(7):695-700.
[23]Mazumder PM, Farswan M, Parcha V. Effect of an isolated active compound (Cg-1) of cassia glauca leaf on blood glucose, lipid profile and atherogenic index in diabetic rats. Indian J Pharmacol. 2009;41(14):182-6.
[24] Vijayaraj P, Muthukumar K, Sabarirajan J, Nachiappan V. Antihyperlipidemic activity of cassia auriculata flowers in triton WR 1339 induced hyperlipidemic rats. Exp Toxicol Pathol. 2013;65(1-2):135-41.
[25] Shanmugasundaram R, Kalpana Devi V, TresinaSoris P, Maruthupandian A, Mohan VR. Antidiabetic, antihyperlipidaemic and antioxidant activity of Senna auriculata (L.) Roxb. leaves in alloxan induced diabetic rats. Int J Pharm Tech Res. 2011;3(2):747-56.
[26] Gholamhoseinian A, Shahouzehi B, Sharifi-Far F. Inhibitory activity of some plant methanol extracts on 3- hydroxy-3-methylglutaryl coenzyme A reductase. Int J Pharm. 2010;6:705-11.
[27] Gholamhoseinian A, Fallah H, Sharififar F. Inhibitory effect of methanol extract of Rosa damascena Mill. flowers on α-glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. Phytomedicine. 2009;16(10):935-41.
[28] Gholamhoseinian A, Shahouzehi B, SharififarF. Inhibitory effect of some plant extract on pancreatic lipase. Int J Pharm. 2010;6(1):18-24.
[29] Mansi K, Abushoffa AM, Disi A, Aburjai T. Hypolipidemic effects of seed extract of celery (Apium graveolens) in rats. Phcog Mag. 2009;5(20):301-5.