@2024 Afarand., IRAN
ISSN: 1735-7675 Kowsar Medical Journal 2010;15(1):31-35
ISSN: 1735-7675 Kowsar Medical Journal 2010;15(1):31-35
Prevalence of Heliobacter pylori antibody in healthy people and patients with rheumatoid arthritis
ARTICLE INFO
Article Type
Original ResearchAuthors
Alishiri Gh. H. (1 )Amini M. (2 )
Bayat N. (1 )
Salimzadeh A. (3 )
Ahmadzad M. (4 )
Ghorbani Gh. A. (* )
(* ) Baqiyatallah Research Center of Gastroenrology & Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran
(1 ) Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
(2 ) Baqiyatallah Research Center of Gastroenrology & Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran
(3 ) Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
(4 ) Nikan Health Research Institute, Tehran, Iran
Correspondence
Article History
Received: February 13, 2008Accepted: September 10, 2008
ePublished:
ABSTRACT
Aims
Rheumatoid arthritis is a chronic disease which causes high costs. Evaluation and reduction of effective factors are useful in the incidence and severity of clinical manifestation of this disease. The aim of this study was to investigate the prevalence of Heliobacter pylori serology in patients with rheumatoid arthritis compared with healthy individuals.
Materials & Methods In this cross-sectional descriptive study, 159 persons who referred to rheumatology clinic of a hospital in Tehran were selected as participants of the study. The level of IgG, IgA and cytotoxin antibody depend on specific gene of Helicobacter pylori were evaluated in serum of individuals with ELISA test. Data were analyzed with independent sample T test and Levien test.
Results The average age of 91 patients with rheumatoid arthritis was 42.5±1.14 and 68 patients of control group were 39±1.4. Anti IgA and IgG serum level in rheumatoid arthritis group were 36.27±3.05 and 27.26±2.05U/ml respectively and their difference was statistically significant (p=0.016). But there was no significant correlation between the serum level of the IgG and cytotoxin antibody depend to specific gene of Helicobacter pylori in participants of patients and control groups (p>0.05).
Conclusion IgA serum level of Helicobacter pylori was higher in rheumatoid arthritis patients comparing with healthy people.
Materials & Methods In this cross-sectional descriptive study, 159 persons who referred to rheumatology clinic of a hospital in Tehran were selected as participants of the study. The level of IgG, IgA and cytotoxin antibody depend on specific gene of Helicobacter pylori were evaluated in serum of individuals with ELISA test. Data were analyzed with independent sample T test and Levien test.
Results The average age of 91 patients with rheumatoid arthritis was 42.5±1.14 and 68 patients of control group were 39±1.4. Anti IgA and IgG serum level in rheumatoid arthritis group were 36.27±3.05 and 27.26±2.05U/ml respectively and their difference was statistically significant (p=0.016). But there was no significant correlation between the serum level of the IgG and cytotoxin antibody depend to specific gene of Helicobacter pylori in participants of patients and control groups (p>0.05).
Conclusion IgA serum level of Helicobacter pylori was higher in rheumatoid arthritis patients comparing with healthy people.
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