@2025 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):192-196
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):192-196
Relation between E-cadherin Expressions in Papillary Thyroid Carcinoma and Some Prognostic Factors
ARTICLE INFO
Article Type
Original ResearchAuthors
Jalali Nadoushan M.R. (*)Davati A. (1)
Hassanpour M. (2)
(*) Pathology Department, Medicine Faculty, Shahed University, Tehran, Iran
(1) Social Medicine & Health Department, Medicine Faculty, Shahed University, Tehran, Iran
(2) Pathology Department, Medicine Faculty, Shahed University, Tehran, Iran
Correspondence
Article History
Received: February 24, 2013Accepted: December 26, 2013
ePublished: January 5, 2014
ABSTRACT
Aims
The purpose of this study was to determine the frequency of E-cadherin expression
in papillary thyroid cancer and its relation with gender, tumor size, and lymph nodes
involvement.
Materials & Methods This study was performed on 73 tissue samples taken from patients with the mean age of 41.85±16.65 years and with papillary thyroid cancer, who referred to Mostafa Khomeini Hospital in Tehran, Iran (2005-2008). The method of staining for determination of E-cadherin expression was immunohistochemistry. The size of tumor, lymph nodes involvement, and their relation were evaluated with E-cadherin expression.
Findings 67% of samples were positive for E-cadherin and 21.9% had lymph nodes involvement. The mean size of patients’ tumor was 3.86±2.38cm. There was not any significant relationship between E-cadherin expression and tumor size and gender but there was a significant and reverse relationship between E-cadherin expression and lymph nodes involvement.
Conclusion Concerning of the role of the E-cadherin in patient prognosis, it seems that as proportion of E-cadherin decreases in tumor cells, the probability of lymph nodes involvement increases.
Materials & Methods This study was performed on 73 tissue samples taken from patients with the mean age of 41.85±16.65 years and with papillary thyroid cancer, who referred to Mostafa Khomeini Hospital in Tehran, Iran (2005-2008). The method of staining for determination of E-cadherin expression was immunohistochemistry. The size of tumor, lymph nodes involvement, and their relation were evaluated with E-cadherin expression.
Findings 67% of samples were positive for E-cadherin and 21.9% had lymph nodes involvement. The mean size of patients’ tumor was 3.86±2.38cm. There was not any significant relationship between E-cadherin expression and tumor size and gender but there was a significant and reverse relationship between E-cadherin expression and lymph nodes involvement.
Conclusion Concerning of the role of the E-cadherin in patient prognosis, it seems that as proportion of E-cadherin decreases in tumor cells, the probability of lymph nodes involvement increases.
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