@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2013;19(3):143-148
ISSN: 2252-0805 The Horizon of Medical Sciences 2013;19(3):143-148
Comparison the effects of Canola and Sunflower oil usage on serum inflammation markers in osteoporosis patients
ARTICLE INFO
Article Type
Original ResearchAuthors
Azemati M. (*)Shaker Hosseini R. (1)
Hekmatdoost A. (1)
Hosseini M. (2)
(*) Department of Nutrition Researches, Nutrition Sciences and Food Technology Faculty, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
(1) Nutrition Department, Nutrition Sciences and Food Technology Faculty, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
(2) National Nutrition and Food Technology Research Institute, Shahid-Beheshti University of Medical Sciences, Tehran, Iran
Correspondence
Address:Phone: +982177417241
Fax: +982122005241
drazemati@gmail.com
Article History
Received: August 25, 2012Accepted: October 8, 2013
ePublished: October 3, 2013
ABSTRACT
Aims
Long-chain omega-3 fatty acids consumed through diet reduces the production of IL-1, IL-6, IL-4, TNF-α by different cells. Osteoporosis increases the risk of bone fractures, particularly in postmenopausal women. The aim of this study was to investigate the effects of canola in comparison to sunflower oil on serum inflammation markers in patients with osteoporosis.
Materials & Methods In a randomized clinical trial, 40 osteoporotic of bone disease center of Shahid Beheshti University of Medical Sciences were selected by available sampling from September 2010 to November 2012. The patients were divided into two groups of canola and sunflower oil. The data were analyzed by SPSS 16 software by coupled and independent T tests.
Findings In sunflower oil group, systolic blood pressure reduced significantly(p=0.001). Serum vitamin D3 was also increased significantly in canola (p=0.03)and sunflower oil groups (p=0.042) at the end of the intervention period in comparison to baseline. Changes of IL-1, IL-4, IL-6, TNF-α level were not significant in the end of the intervention period in comparison to baseline in both groups.
Conclusion The consumption of canola in comparison to sunflower oil, do not have any effect on reduction of inflammatory biomarkers in osteoporosic.
Materials & Methods In a randomized clinical trial, 40 osteoporotic of bone disease center of Shahid Beheshti University of Medical Sciences were selected by available sampling from September 2010 to November 2012. The patients were divided into two groups of canola and sunflower oil. The data were analyzed by SPSS 16 software by coupled and independent T tests.
Findings In sunflower oil group, systolic blood pressure reduced significantly(p=0.001). Serum vitamin D3 was also increased significantly in canola (p=0.03)and sunflower oil groups (p=0.042) at the end of the intervention period in comparison to baseline. Changes of IL-1, IL-4, IL-6, TNF-α level were not significant in the end of the intervention period in comparison to baseline in both groups.
Conclusion The consumption of canola in comparison to sunflower oil, do not have any effect on reduction of inflammatory biomarkers in osteoporosic.
CITATION LINKS
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[17] Sun SZ, Empie MW, Flickinger B, Tian Hx Liu Y, Wang X, Zhang W. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. J Nutr. 2008;99(6):1301-9.
[18] Masse B, Forest JC, Legare F, Jacques H, Lemay A, Dodin S. The effects of flaxseed dietary supplement on lipid profile, bone mineral density and symptoms in menopausal women: A randomized, double-blind, wheat germ placebocontrolled clinical trial. J Clin Endocrinol Metab. 2005;90(3):1390-7.
[19] Boulbaroud S, Mesfioui A, Arfaoui A, Ouichou A, Hessni A. Preventive effects of flaxseed and sesame oil on bone loss in ovariectomized rats. Pak J Biol Sci. 2008;11(13):1696-701.
[20] Schiano V, Laurenzano E, Brevetti G. Omega-3 polyunsaturated fatty acid in peripheral arterial disease: Effect on lipid pattern, disease severity, inflammation profile and endothelial function. Clin Nutr. 2008;27(2):241- 7.
[21] Wright SA, OPrey FM, McHenry MT. A randomized interventional trial of omega-3 polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. Ann Rheum Dis. 2008;67(6):841-8.
[22] Han DC, Watts GF, Barrett PH, Beilin LJ, Mori TA. Effect of atorvastatin and fish oil on plasma high sensitivity C-reactive protein concentrations in individuals with visceral obesity. Clin Chem. 2002;48(6):877-83.
[23] Mori TA, Woodman RJ, Burke V, Puddey IB, Croft KD, Beilin LJ. Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. Free Radic Biol Med. 2003;35(7):772-81.
[24] Kew S, Banerjee T, Minihane AM. Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. Am J Clin Nutr. 2003;77(5):1287-95.
[25] Blok WL, Deslypere JP, Demacker PN. Pro and antiinflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year. Euro J Clin Invest. 1997;27(12):1003-8.
[26] Skulas-Ray AC, Kris-Etherton PM, Harris WS, Vanden Heuvel JP, Wagner PR, West SG. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr. 2011;93(2):243-52.
[27] Caughey GE, Mantzioris E, Gibson RA. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr. 1996;63(1):116-22.
[28] Endres S, Ghorbani R, Kelley VE. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Eng J Med. 1989;320(5):265-71.
[29] Hur SJ, Park Y. Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis. Eur J Pharmacology. 2007;31:252-65.
[30] Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G. Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem. 2006;17(12):789- 810.
[31] Gheita T, Kamel S, Helmy N, El-Laithy N, Monir A. Omega-3 fatty acids in juvenile idiopathic arthritis: Effect on cytokines (IL-1 and TNF-α), disease activity and response criteria. Clin Rheumatol. 2012;31(2):363-6.
[32] Garman JH, Mulroney S, Manigrasso M, Flynn E, Maric C. Omega-3 fatty acid rich diet prevents diabetic renal disease. Am J Physiol Renal Physiol. 2009;296(2):306-16.
[33] Esmaillzadeh A, Azadbakht L. Home use of vegetable oils, markers of systemic inflammation and endothelial dysfunction among women. Am J Clin Nutr. 2008;88(4):913-21.
[34] Stubbs CD, Smith AD. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta. 1984;779(1):89-137.
[35] Schaefer MB, Wenzel A, Fischer T. Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: Impact on adhesion and apoptosis. Atherosclerosis. 2008;197(2):630-7.
[36] Blok WL, Katan MB, van der Meer JW. Modulation of inflammation and cytokine production by dietary (n-3) fatty acids. J Nutr. 1996;126(6):1515-33.
[2] McGarry KA, Kiel DP. Postmenopausal osteoporosis: Strategies for preventing bone loss, avoiding fracture. Postgrad Med. 2000;108(3):79-82.
[3] Johnell O. The socioeconomic burden of fractures: Today and in the 21st century. Am J Med. 1997;103(2):20-5.
[4] Partt AM. Quantum concept of bone remodeling and turnover implications for the pathogenesis of osteoporosis. Calcif Tissue Int. 1979;28(1):1-5.
[5] Johnell O, Kanis J. Epidemiology of osteoporotic fractures. Osteoporosis Int. 2005;16(2):3-7.
[6] MacKelvie KJ, Khan KM, McKay HA. Is there a critical period for bone response to weight-bearing exercise in children and adolescents? A systematic review. Br J Sports Med. 2002;36(4):250-7.
[7] Ralston SH. Genetics of osteoporosis. Ann N Y Acad Sci. 2010;1192(1):181-9.
[8] Morris DH. Methodologic challenges in designing clinical studies to measure differences in the bioequivalence of n-3 fatty acids. Mol Cell Biochem. 2003;246(1-2):83-90.
[9] Cleland LG, James MJ, Neumann MA. Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects. Am J Clin Nutr. 1992;55(2):395-9.
[10] Un D, Krishnan A, Zaman K, Lawrence R, Bhattacharya A, Fernandes G. Dietary fatty acids decrease osteoclastogenesis and loss of bone mass in ovariectomized mice. J Bone Miner Res. 2003;18(7):1206-16.
[11] Watkins BA, Li Y, Lippman HE, Feng S. Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism. Prostaglandins Leukot Essent Fatty Acids. 2003;68(6):387-98.
[12] Paschos GK, Magkos F, Panagiotakos DB, Votteas V, Zampelas A. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr. 2007;61(10):1201-6.
[13] Basch E, Bent S, Collins J, Dacey C, Hammerness P. Flax and flaxseed oil (Linum usitatissimum): A review by the Natural Standard Research Collaboration. J Soc Integr Oncol. 2007;5(3):92-105.
[14] Barcel-Coblijn G, Murphy EJ, Othman R, Moghadasian MH. Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: A multiple-dosing trial comparing 2 sources of n-3 fatty acid. Am J Clin Nutr. 2008;88(3):801-9.
[15] Paschos GK, Zampelas A, Panagiotakos DB, Katsiougiannis S, Griffin BA, Votteas V. Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. Eur J Nutr. 2007;46(6):315-20.
[16] Paschos GK, Zampelas A, Panagiotakos DB, Katsiougiannis S, Griffin BA, Votteas V. Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men. Eur J Nutr. 2007;46(6):315-20.
[17] Sun SZ, Empie MW, Flickinger B, Tian Hx Liu Y, Wang X, Zhang W. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. J Nutr. 2008;99(6):1301-9.
[18] Masse B, Forest JC, Legare F, Jacques H, Lemay A, Dodin S. The effects of flaxseed dietary supplement on lipid profile, bone mineral density and symptoms in menopausal women: A randomized, double-blind, wheat germ placebocontrolled clinical trial. J Clin Endocrinol Metab. 2005;90(3):1390-7.
[19] Boulbaroud S, Mesfioui A, Arfaoui A, Ouichou A, Hessni A. Preventive effects of flaxseed and sesame oil on bone loss in ovariectomized rats. Pak J Biol Sci. 2008;11(13):1696-701.
[20] Schiano V, Laurenzano E, Brevetti G. Omega-3 polyunsaturated fatty acid in peripheral arterial disease: Effect on lipid pattern, disease severity, inflammation profile and endothelial function. Clin Nutr. 2008;27(2):241- 7.
[21] Wright SA, OPrey FM, McHenry MT. A randomized interventional trial of omega-3 polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. Ann Rheum Dis. 2008;67(6):841-8.
[22] Han DC, Watts GF, Barrett PH, Beilin LJ, Mori TA. Effect of atorvastatin and fish oil on plasma high sensitivity C-reactive protein concentrations in individuals with visceral obesity. Clin Chem. 2002;48(6):877-83.
[23] Mori TA, Woodman RJ, Burke V, Puddey IB, Croft KD, Beilin LJ. Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. Free Radic Biol Med. 2003;35(7):772-81.
[24] Kew S, Banerjee T, Minihane AM. Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. Am J Clin Nutr. 2003;77(5):1287-95.
[25] Blok WL, Deslypere JP, Demacker PN. Pro and antiinflammatory cytokines in healthy volunteers fed various doses of fish oil for 1 year. Euro J Clin Invest. 1997;27(12):1003-8.
[26] Skulas-Ray AC, Kris-Etherton PM, Harris WS, Vanden Heuvel JP, Wagner PR, West SG. Dose-response effects of omega-3 fatty acids on triglycerides, inflammation and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr. 2011;93(2):243-52.
[27] Caughey GE, Mantzioris E, Gibson RA. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr. 1996;63(1):116-22.
[28] Endres S, Ghorbani R, Kelley VE. The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Eng J Med. 1989;320(5):265-71.
[29] Hur SJ, Park Y. Effect of conjugated linoleic acid on bone formation and rheumatoid arthritis. Eur J Pharmacology. 2007;31:252-65.
[30] Bhattacharya A, Banu J, Rahman M, Causey J, Fernandes G. Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem. 2006;17(12):789- 810.
[31] Gheita T, Kamel S, Helmy N, El-Laithy N, Monir A. Omega-3 fatty acids in juvenile idiopathic arthritis: Effect on cytokines (IL-1 and TNF-α), disease activity and response criteria. Clin Rheumatol. 2012;31(2):363-6.
[32] Garman JH, Mulroney S, Manigrasso M, Flynn E, Maric C. Omega-3 fatty acid rich diet prevents diabetic renal disease. Am J Physiol Renal Physiol. 2009;296(2):306-16.
[33] Esmaillzadeh A, Azadbakht L. Home use of vegetable oils, markers of systemic inflammation and endothelial dysfunction among women. Am J Clin Nutr. 2008;88(4):913-21.
[34] Stubbs CD, Smith AD. The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta. 1984;779(1):89-137.
[35] Schaefer MB, Wenzel A, Fischer T. Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: Impact on adhesion and apoptosis. Atherosclerosis. 2008;197(2):630-7.
[36] Blok WL, Katan MB, van der Meer JW. Modulation of inflammation and cytokine production by dietary (n-3) fatty acids. J Nutr. 1996;126(6):1515-33.