@2025 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):212-217
ISSN: 2252-0805 The Horizon of Medical Sciences 2014;19(4):212-217
Evaluation Incidence of Helicobacter pylori Infection in Gastric Adenocarcinoma
ARTICLE INFO
Article Type
Original ResearchAuthors
Maddah Gh. (1)Abdollahi A. (*)
Khajeh Karamadini M. (2)
Nakhaeizadeh S. (3)
Jabbari Noughabi A. (4)
Jangjoo A. (4)
Shabahang H. (1)
Alvandipour M. (5)
(*) Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
(1) Endoscopic and Minimally Invasive Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
(2) Microbiology Department, Medicine Faculty, Mashhad University of Medical Sciences, Mashhad, Iran
(3) 3Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
(4) Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
(5) Surgery Department, Medicine Faculty, Mazandaran University of Medical Sciences, Mazandaran, Iran
Correspondence
Article History
Received: June 7, 2013Accepted: December 26, 2013
ePublished: January 5, 2014
ABSTRACT
Aims
The aim of the present study was to investigate the presence of Helicobacter pylori
microorganism in gastric cancer in different regions of the stomach and to compare it with
non-malignant lesions.
Materials & Methods Samples were obtained from 50 confirmed cases of gastric adenocarcinoma, undergoing gastrectomy. Gastric tissue of 50 patients who underwent endoscopy without gastric cancer was obtained as control samples. All patients were matched with regard to age and sex. The urease test and histology were used for the diagnosis of H. pylori infection. The prevalence of H. pylori was compared between the two groups. The data analysis was performed, using SPSS 16 through student T, Chi-square and Fisher exact tests.
Findings The prevalence of H. pylori infection in gastric adenocarcinoma group was 92% and in the control group was 60%. The prevalence of H. pylori infection in gastric adenocarcinoma patients was 100% in the antropyloric region and 95% in the body of the stomach.
Conclusion There is a significant correlation between Helicobacter pylori infection and risk of gastric adenocarcinoma.
Materials & Methods Samples were obtained from 50 confirmed cases of gastric adenocarcinoma, undergoing gastrectomy. Gastric tissue of 50 patients who underwent endoscopy without gastric cancer was obtained as control samples. All patients were matched with regard to age and sex. The urease test and histology were used for the diagnosis of H. pylori infection. The prevalence of H. pylori was compared between the two groups. The data analysis was performed, using SPSS 16 through student T, Chi-square and Fisher exact tests.
Findings The prevalence of H. pylori infection in gastric adenocarcinoma group was 92% and in the control group was 60%. The prevalence of H. pylori infection in gastric adenocarcinoma patients was 100% in the antropyloric region and 95% in the body of the stomach.
Conclusion There is a significant correlation between Helicobacter pylori infection and risk of gastric adenocarcinoma.
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