@2024 Afarand., IRAN
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2019;3(1):1-4
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2019;3(1):1-4
Prevalence of Group B Streptococcus in the Vagina of 35-37-Week Pregnant Women
ARTICLE INFO
Article Type
Original ResearchAuthors
Seyedi Moghadam N. (*1)Nomanpour B. (2)
Lashgari P. ()
() MicrobiologyDepartment, Medicine Faculty, Kerman University of Medical Sciences, Kerman, Iran
(*1) Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran
(2) Sarem Cell Research Center (SCRC), Sarem Women Hospital, Tehran, Iran
Correspondence
Address: Sarem Women Hospital, Basij Square, Phase 3, Ekbatan Town, Tehran, Iran. Postal Code: 1396956111Phone: +98 (21) 44670888
Fax: +98 (21) 44670432
nayereh.seyedimoghaddam@gmail.com
Article History
Received: July 16, 2017Accepted: October 2, 2017
ePublished: January 4, 2019
ABSTRACT
Aims
Group B Streptococcus (GBS) is a genus of gram-positive diplococci that can be colonized in the genital tract of women and can be transferred to the neonates from the genital tract and make septicemia. Due to the importance of neonatal septicemia and its complications, this study was aimed to evaluate the prevalence of GBS in the vagina of 35-37-week pregnant women.
Materials & Methods This descriptive study was conducted on 1610 pregnant women at 35-37 weeks of pregnancy who referred to prenatal clinic of Sarem Women’s Hospital (Tehran, Iran) in a period of 18 months from 2010-2012. The vaginal secretion specimens were obtained from each pregnant woman and were studied by routine diagnostic tests including catalase and CAMP tests and Gram-staining method. The prevalence and demographic data were analyzed using SPSS 18 software.
Findings The prevalence of GBS among pregnant women was 119 cases (7.4%) in the 35-37 weeks of pregnancy. 96.5% of GBS carriers were in the age range of 21-45 years of which 57% were under 30 years old and 43% more than 30 years old. The educational level in 90% of them was bachelor and lower. In 97% of pregnant women carrying GBS, no disease was observed. All 119 patients who were positive for GBS had a good weight gain during pregnancy. 91% of pregnant women with GBS, had no history of infertility.
Conclusion The prevalence of GBS in pregnant women is 7.4% in the 35-37 weeks of pregnancy, which is lower than other countries.
Materials & Methods This descriptive study was conducted on 1610 pregnant women at 35-37 weeks of pregnancy who referred to prenatal clinic of Sarem Women’s Hospital (Tehran, Iran) in a period of 18 months from 2010-2012. The vaginal secretion specimens were obtained from each pregnant woman and were studied by routine diagnostic tests including catalase and CAMP tests and Gram-staining method. The prevalence and demographic data were analyzed using SPSS 18 software.
Findings The prevalence of GBS among pregnant women was 119 cases (7.4%) in the 35-37 weeks of pregnancy. 96.5% of GBS carriers were in the age range of 21-45 years of which 57% were under 30 years old and 43% more than 30 years old. The educational level in 90% of them was bachelor and lower. In 97% of pregnant women carrying GBS, no disease was observed. All 119 patients who were positive for GBS had a good weight gain during pregnancy. 91% of pregnant women with GBS, had no history of infertility.
Conclusion The prevalence of GBS in pregnant women is 7.4% in the 35-37 weeks of pregnancy, which is lower than other countries.
CITATION LINKS
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[3]Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States,1999-2005. J Am Med Assoc. 2008;299(17):2056-65
[4]Regan JA, Klebanoff MA, Nugent RP, Eschenbach DA, Blackwelder WC, Lou Y, et al. Colonization with group B streptococciin pregnancy and adverse outcome. Am J Obstet Gynecol. 1996;174(4):1354-60.
[5]Krohn MA, Hillier SL, Baker CJ. Maternal peripartum complications associated with vaginal group B streptococci colonization. J Infect Dis. 1999;179(6):1410-5.
[6]Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342(1):15-20.
[7]Zaleznik DF, Rench MA, Hillier S, Krohn MA, Platt R, Lee ML, et al. Invasive disease due to group B Streptococcus in pregnant women and neonates from diverse population groups. Clin Infect Dis. 2000;30(2):276-81.
[8] Valkenburg-Van Den Berg AW, Sprij AJ, Dekker FW, DÖrr PJ, Kanhai HH. Association between colonization with Group B Streptococcus and preterm delivery: A systematic review. Acta Obstet Gynecol Scand. 2009;88(9):958-67.
[9] Romero R, Oyarzun E, Mazor M, Sirtori M, Hobbins JC, Bracken M. Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol. 1989;73(4):576-82.
[10]Mittendorf R, Williams MA, Kass EH. Prevention of preterm delivery and low birth weight associated with asymptomatic bacteriuria. Clin Infect Dis. 1992;14(4):927-32
[11]Anderson BL, Simhan HN, Simons KM, Wiesenfeld HC. Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery. Am J Obstet Gynecol. 2007;196(6):524.e1-5.
[12]Wood EG, Dillon HC, Jr. A prospective study of group B streptococcal bacteriuria in pregnancy. Am J Obstet Gynecol. 1981;140(5):515-20.
[13]Persson K, Bjerre B, Elfstrom L, Polberger S, Forsgren A. Group B streptococci at delivery: high count in urine increases risk for neonatal colonization. Scand J Infect Dis. 1986;18(6):525-31.
[14]Yu Hw, Lin HC, Yang PH, Hsu CH, Hsieh WS, Tsao LY, et al. Group B streptococal in Taiwan: Maternal clononization and neonatal infection. Pediatr Neonatol. 2011;52(4):190-5.
[15]Valkenburg-Van Den Berg AW, Sprij Aj, Oostvogel PM, Mutsaers JA, Renes WB, Rosendaal FR, et al. Prevalence of colonization with group B streptococci in pregnant women of a multi-ethnic population in the netherlands. Eur J Obstet Gynecol Reprod Biol. 2006;124(2):178-83.
[2]Verani JR, McGee L, Schrag SJ. Prevention of perinatal group B streptococcal disease--revised guidelines from CDC, 2010. Cent Dis Control. 2010;59(10):1-36.
[3]Phares CR, Lynfield R, Farley MM, Mohle-Boetani J, Harrison LH, Petit S, et al. Epidemiology of invasive group B streptococcal disease in the United States,1999-2005. J Am Med Assoc. 2008;299(17):2056-65
[4]Regan JA, Klebanoff MA, Nugent RP, Eschenbach DA, Blackwelder WC, Lou Y, et al. Colonization with group B streptococciin pregnancy and adverse outcome. Am J Obstet Gynecol. 1996;174(4):1354-60.
[5]Krohn MA, Hillier SL, Baker CJ. Maternal peripartum complications associated with vaginal group B streptococci colonization. J Infect Dis. 1999;179(6):1410-5.
[6]Schrag SJ, Zywicki S, Farley MM, Reingold AL, Harrison LH, Lefkowitz LB, et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med. 2000;342(1):15-20.
[7]Zaleznik DF, Rench MA, Hillier S, Krohn MA, Platt R, Lee ML, et al. Invasive disease due to group B Streptococcus in pregnant women and neonates from diverse population groups. Clin Infect Dis. 2000;30(2):276-81.
[8] Valkenburg-Van Den Berg AW, Sprij AJ, Dekker FW, DÖrr PJ, Kanhai HH. Association between colonization with Group B Streptococcus and preterm delivery: A systematic review. Acta Obstet Gynecol Scand. 2009;88(9):958-67.
[9] Romero R, Oyarzun E, Mazor M, Sirtori M, Hobbins JC, Bracken M. Meta-analysis of the relationship between asymptomatic bacteriuria and preterm delivery/low birth weight. Obstet Gynecol. 1989;73(4):576-82.
[10]Mittendorf R, Williams MA, Kass EH. Prevention of preterm delivery and low birth weight associated with asymptomatic bacteriuria. Clin Infect Dis. 1992;14(4):927-32
[11]Anderson BL, Simhan HN, Simons KM, Wiesenfeld HC. Untreated asymptomatic group B streptococcal bacteriuria early in pregnancy and chorioamnionitis at delivery. Am J Obstet Gynecol. 2007;196(6):524.e1-5.
[12]Wood EG, Dillon HC, Jr. A prospective study of group B streptococcal bacteriuria in pregnancy. Am J Obstet Gynecol. 1981;140(5):515-20.
[13]Persson K, Bjerre B, Elfstrom L, Polberger S, Forsgren A. Group B streptococci at delivery: high count in urine increases risk for neonatal colonization. Scand J Infect Dis. 1986;18(6):525-31.
[14]Yu Hw, Lin HC, Yang PH, Hsu CH, Hsieh WS, Tsao LY, et al. Group B streptococal in Taiwan: Maternal clononization and neonatal infection. Pediatr Neonatol. 2011;52(4):190-5.
[15]Valkenburg-Van Den Berg AW, Sprij Aj, Oostvogel PM, Mutsaers JA, Renes WB, Rosendaal FR, et al. Prevalence of colonization with group B streptococci in pregnant women of a multi-ethnic population in the netherlands. Eur J Obstet Gynecol Reprod Biol. 2006;124(2):178-83.