@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(3):229-234
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(3):229-234
Effects of 10 Weeks of Aerobic Training in Water on Chemerin and Insulin Resistance in Women with Multiple Sclerosis
ARTICLE INFO
Article Type
Original ResearchAuthors
Sadegh S. (* )Golestany A. (1 )
(* ) Sport Physiology Department, Physical Education & Sport Sciences Faculty, University of Bojnourd, Bojnourd, Iran
(1 ) Sport Physiology Department, Physical Education & Sport Sciences Faculty, University of Bojnourd , Bojnourd, Iran
Correspondence
Address: Physical Education & Sport Sciences Faculty, University of Bojnourd, Km 4 Esfarayen Road, Bojnourd, IranPhone: +98 (58) 32201000
Fax: +98 (58) 32201000
sadegh.saba1989@gmail.com
Article History
Received: July 26, 2016Accepted: February 18, 2017
ePublished: July 22, 2017
ABSTRACT
Aims
Multiple sclerosis (MS) is a result of the destruction of myelin cells in the central nervous system, which can damage the motor system, increase fatigue and decrease the daily activity of life. The aim of the study was to investigate the effect of 10 weeks of aerobic exercise in water on the levels of chemerin, insulin and serum insulin resistance in women with (MS).
Materials & Methods In the semi-experimental study with pre-test and post-test design with control group in 2015, 29 MS female patients were selected through available and targeted sampling method and were divided into two experimental groups (n = 15) and control (n = 14). The aerobic exercise program included 10 weeks of aerobic exercise in water, each week 3 sessions, and each session for 45 to 60 minutes with an intensity equal to 60 to 75% of the maximum heart rate. Chromic and serum insulin values were measured before and after the end of the aerobic exercise period. Data were analyzed by SPSS 20 software using two-way ANOVA and paired T tests.
Findings 10-week aerobic exercise program in water resulted in a significant decrease in average of chemerin levels (p=0.01), fasting glucose (p=0.03), insulin (p=0.04) and insulin resistance (p=0.01) in women with (MS), but there was no significant difference in mean body mass and body mass index (p<0.05).
Conclusion 10 weeks of aerobic exercise in water leads to lower levels of chemerin, insulin and serum insulin resistance in women with MS.
Materials & Methods In the semi-experimental study with pre-test and post-test design with control group in 2015, 29 MS female patients were selected through available and targeted sampling method and were divided into two experimental groups (n = 15) and control (n = 14). The aerobic exercise program included 10 weeks of aerobic exercise in water, each week 3 sessions, and each session for 45 to 60 minutes with an intensity equal to 60 to 75% of the maximum heart rate. Chromic and serum insulin values were measured before and after the end of the aerobic exercise period. Data were analyzed by SPSS 20 software using two-way ANOVA and paired T tests.
Findings 10-week aerobic exercise program in water resulted in a significant decrease in average of chemerin levels (p=0.01), fasting glucose (p=0.03), insulin (p=0.04) and insulin resistance (p=0.01) in women with (MS), but there was no significant difference in mean body mass and body mass index (p<0.05).
Conclusion 10 weeks of aerobic exercise in water leads to lower levels of chemerin, insulin and serum insulin resistance in women with MS.
CITATION LINKS
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[9]Ernst MC, Sinal CJ. Chemerin: At the crossroads of inflammation and obesity. Trends Endocrinol Metab. 2010;21(11):660-7.
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[13]Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, et al. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes. 2009;58(12):2731-40.
[14]Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, et al. Chemerin enhances insulin signaling and potentiates insulin‐stimulated glucose uptake in 3T3‐L1 adipocytes. FEBS Lett. 2008;582(5):573-8.
[15]Gray SR, Baker G, Wright A, Fitzsimons CF, Mutrie N, Nimmo MA, et al. The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation. Prev Med. 2009;48(1):39-44.
[16]Carrel AL, McVean JJ, Clark RR, Peterson SE, Eickhoff JC, Allen DB. School-based exercise improves fitness, body composition, insulin sensitivity, and markers of inflammation in non-obese children. J Pediatr Endocrinol Metab.2009;22(5):409-15.
[17]Ghanbarzadeh M, Kazemi A. The comparison of three different concurrent training on chemerin plasma levels, insulin resistance and physical performance in elderly women. J Knowledge Health. 2016;10(4):40-7. [Persian]
[18]Malayeri S, Nikbakht H, Gaeini AA. Serum chemerin levels and insulin resistance response to high-intensity interval training in overweight men. Bull Environ Pharmacol Life Sci.2 014;3(2):385-9. [Persian]
[19]Stefanov T, Blüher M, Vekova A, Bonova I, Tzvetkov S, Kurktschiev D, et al. Circulating chemerin decreases in response to a combined strength and endurance training. Endocrine. 2014;45(3):382-91.
[20]Salehiomran M, JafariS. Association of admission insulin resistance index with early cardiac complications in non diabetic patients with acute coronary syndrome. J Babol Univ Med Sci. 2009;10(6):62-6. [Persian]
[21]Maliqueo M, Pérez-Bravo F, Calvillán M, Piwonka V, Castillo T, Sir-Petermann T. Relationship between leptin and insulin sensitivity in patients with polycystic ovary syndrome. Med Clin. 1999;113(14):526-30. [Spanish]
[22]Sâmpelean D, Hănescu B, Han A, Adam M, Casoinic F. The prognosis of glycoregulation disturbances and insulin secretion in alcoholic and c virus liver cirrhosis. Rom J Intern Med. 2009;47(4):387-92
[23]Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian J Sports Med. 2010;1(3):151-8. [Persian]
[24]Aghapour A, Farzanegi P. Effect of six-week aerobic exercise on Chemerin and Resistin concentration in hypertensive postmenopausal women. Electron Physician. 2013;5(1):623-30. [Persian]
[25]Lloyd JW, Evans KA, Zerfass KM, Holmstrup ME, Kanaley JA, Keslacy S. Effect of an acute bout of aerobic exercise on chemerin levels in obese adults. Diabetes Metab Syndr. 2016;10(1):37-42.
[26]Banitalebi E, Mardanpour Shahrekordi Z, Kazemi AR, Bagheri L, Amani Shalamzari S, Faramarzi M. Comparing the effects of eight weeks of combined training (endurance and resistance) in different orders on inflammatory factors and adipokines among elderly females. Women's Health Bull. 2016;3(2):e30990.
[27]Stejskal D, Karpisek M, Hanulova Z, Svestak M. Chemerin is an independent marker of the metabolic syndrome in a Caucasian population–a pilot study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008;152(2):217-21.
[28]Bashiri J, Rahbaran A, Gholami F, Ahmadizad S, Nikoukheslat S, Moradi A. The effect of acute exercise on serum vaspin level and its relation to insulin sensitivity in overweight elderly men. Zahedan J Res Med Sci. 2014;16(8):16-9. [Persian]
[29]Nádia F, Carmem P, Silva V, Maycon JR. Leandro K. Rocha T. 7-week aerobic exercise training reduces adipocyte area and improves insulin sensitivity in Wistar rats fed a highly palatable diet. Motriz Rev Educ Fís. 2016;22(1):12-7.
[30]Faramarzi M, Banitalebi E, Nori S, Farzin S, Taghavian Z. Effects of rhythmic aerobic exercise plus core stability training on serum omentin, chemerin and vaspin levels and insulin resistance of overweight women. J Sports Med Phys Fitness. 2016;56(4):476-82.
[31]Attarzadeh Hosseinim SR, Mir E, Hejazi K, Mir Saidy M. The Effect of eight weeks combined training on some insulin resistance markers in middle-aged men. Med J Mashhad Univ Med Sci. 2015;58(3):129-36. [Persian]
[32]Eriksson J, Taimela S, Eriksson K, Parviainen S, Peltonen J, Kujala U. Resistance training the treatment of non-insulin-dependent diabetes mellitus. Int J Sports Med. 1997;18(4):242-6.
[33]Das UN. Metabolic syndrome pathophysiology: The role of essential fatty acids. Hoboken, New Jersey: Wiley-Blackwell; 2010.
[34]Kazemi F, Zahedi Asl S. The correlation of plasma levels of apelin-13 with insulin resistance index and plasma leptin of diabetic male rats after 8-week aerobic exercise. Arak Med Univ J. 2015;18(6):51-60. [Persian]
[2]Taraghi Z, IIali E. Quality of life among multiple sclerosis patients. J Appl Sci. 2010;10(14):1485-8.
[3]Bezheh N, Soltani M, Khaleghzade H. Effects of aerobic training in water on IL-6 and IL-10 in patients with Multiple Sclerosis. Evid Based Care. 2014;4(2):63-72. [Persian]
[4]Drenick EJ, Bale GS, Seltzer F, Johnson DG. Excessive mortality and causes of death in morbidly obese men. JAMA. 1980;243(5):443-5.
[5]Colditz GA. Economic costs of obesity and inactivity. Med Sci Sports Exerc. 1999;31(11 Suppl):S663-7.
[6]Oliveira SR, Simão AN, Kallaur AP, Almeida ER, Morimoto HK, Lopes J, et al. Disability in patients with multiple sclerosis: Influence of insulin resistance, adiposity, and oxidative stress. Nutrition. 2014;30(3):268-73.
[7]Hill JM, Lesniaka MA, Pert CB, Roth J. Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas. Neuroscience. 1986;17(4):1127-38.
[8]Watson GS, Craft S. Insulin resistance, inflammation, and cognition in Alzheimer's Disease: Lessons for multiple sclerosis. J Neurol Sci. 2006;245(1-2):21-33.
[9]Ernst MC, Sinal CJ. Chemerin: At the crossroads of inflammation and obesity. Trends Endocrinol Metab. 2010;21(11):660-7.
[10]Saghebjoo M, Fathi R, Talebi Ghorghani E, Hosseini Kakhak A, Ghanbari Niaki A, Hedayati M. Obestatin and the regulation of energy balance in physical activity. Iran J Endocrinol Metab. 2011;12(6):647-55. [Persian]
[11]Bozaoglu K, Bolton K, McMillan J, Zimmet P, Jowett J, Collier G, et al. Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Endocrinology. 2007;148(10):4687-94.
[12]Wang LY, Wei L, Yu HY, Zhang Y, Jia WP. Relationship of serum Chemerin to obesity and type 2 diabetes mellitus. Zhonghua Yi Xue Za Zhi. 2009;89(4):235-8. [Chinese]
[13]Sell H, Laurencikiene J, Taube A, Eckardt K, Cramer A, Horrighs A, et al. Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells. Diabetes. 2009;58(12):2731-40.
[14]Takahashi M, Takahashi Y, Takahashi K, Zolotaryov FN, Hong KS, Kitazawa R, et al. Chemerin enhances insulin signaling and potentiates insulin‐stimulated glucose uptake in 3T3‐L1 adipocytes. FEBS Lett. 2008;582(5):573-8.
[15]Gray SR, Baker G, Wright A, Fitzsimons CF, Mutrie N, Nimmo MA, et al. The effect of a 12 week walking intervention on markers of insulin resistance and systemic inflammation. Prev Med. 2009;48(1):39-44.
[16]Carrel AL, McVean JJ, Clark RR, Peterson SE, Eickhoff JC, Allen DB. School-based exercise improves fitness, body composition, insulin sensitivity, and markers of inflammation in non-obese children. J Pediatr Endocrinol Metab.2009;22(5):409-15.
[17]Ghanbarzadeh M, Kazemi A. The comparison of three different concurrent training on chemerin plasma levels, insulin resistance and physical performance in elderly women. J Knowledge Health. 2016;10(4):40-7. [Persian]
[18]Malayeri S, Nikbakht H, Gaeini AA. Serum chemerin levels and insulin resistance response to high-intensity interval training in overweight men. Bull Environ Pharmacol Life Sci.2 014;3(2):385-9. [Persian]
[19]Stefanov T, Blüher M, Vekova A, Bonova I, Tzvetkov S, Kurktschiev D, et al. Circulating chemerin decreases in response to a combined strength and endurance training. Endocrine. 2014;45(3):382-91.
[20]Salehiomran M, JafariS. Association of admission insulin resistance index with early cardiac complications in non diabetic patients with acute coronary syndrome. J Babol Univ Med Sci. 2009;10(6):62-6. [Persian]
[21]Maliqueo M, Pérez-Bravo F, Calvillán M, Piwonka V, Castillo T, Sir-Petermann T. Relationship between leptin and insulin sensitivity in patients with polycystic ovary syndrome. Med Clin. 1999;113(14):526-30. [Spanish]
[22]Sâmpelean D, Hănescu B, Han A, Adam M, Casoinic F. The prognosis of glycoregulation disturbances and insulin secretion in alcoholic and c virus liver cirrhosis. Rom J Intern Med. 2009;47(4):387-92
[23]Saremi A, Shavandi N, Parastesh M, Daneshmand H. Twelve-week aerobic training decreases chemerin level and improves cardiometabolic risk factors in overweight and obese men. Asian J Sports Med. 2010;1(3):151-8. [Persian]
[24]Aghapour A, Farzanegi P. Effect of six-week aerobic exercise on Chemerin and Resistin concentration in hypertensive postmenopausal women. Electron Physician. 2013;5(1):623-30. [Persian]
[25]Lloyd JW, Evans KA, Zerfass KM, Holmstrup ME, Kanaley JA, Keslacy S. Effect of an acute bout of aerobic exercise on chemerin levels in obese adults. Diabetes Metab Syndr. 2016;10(1):37-42.
[26]Banitalebi E, Mardanpour Shahrekordi Z, Kazemi AR, Bagheri L, Amani Shalamzari S, Faramarzi M. Comparing the effects of eight weeks of combined training (endurance and resistance) in different orders on inflammatory factors and adipokines among elderly females. Women's Health Bull. 2016;3(2):e30990.
[27]Stejskal D, Karpisek M, Hanulova Z, Svestak M. Chemerin is an independent marker of the metabolic syndrome in a Caucasian population–a pilot study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2008;152(2):217-21.
[28]Bashiri J, Rahbaran A, Gholami F, Ahmadizad S, Nikoukheslat S, Moradi A. The effect of acute exercise on serum vaspin level and its relation to insulin sensitivity in overweight elderly men. Zahedan J Res Med Sci. 2014;16(8):16-9. [Persian]
[29]Nádia F, Carmem P, Silva V, Maycon JR. Leandro K. Rocha T. 7-week aerobic exercise training reduces adipocyte area and improves insulin sensitivity in Wistar rats fed a highly palatable diet. Motriz Rev Educ Fís. 2016;22(1):12-7.
[30]Faramarzi M, Banitalebi E, Nori S, Farzin S, Taghavian Z. Effects of rhythmic aerobic exercise plus core stability training on serum omentin, chemerin and vaspin levels and insulin resistance of overweight women. J Sports Med Phys Fitness. 2016;56(4):476-82.
[31]Attarzadeh Hosseinim SR, Mir E, Hejazi K, Mir Saidy M. The Effect of eight weeks combined training on some insulin resistance markers in middle-aged men. Med J Mashhad Univ Med Sci. 2015;58(3):129-36. [Persian]
[32]Eriksson J, Taimela S, Eriksson K, Parviainen S, Peltonen J, Kujala U. Resistance training the treatment of non-insulin-dependent diabetes mellitus. Int J Sports Med. 1997;18(4):242-6.
[33]Das UN. Metabolic syndrome pathophysiology: The role of essential fatty acids. Hoboken, New Jersey: Wiley-Blackwell; 2010.
[34]Kazemi F, Zahedi Asl S. The correlation of plasma levels of apelin-13 with insulin resistance index and plasma leptin of diabetic male rats after 8-week aerobic exercise. Arak Med Univ J. 2015;18(6):51-60. [Persian]