@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(4):279-283
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(4):279-283
Effect of 8 Weeks Resistance Training on Some Antioxidant/Oxidative Indexes in Postmenopausal Women with Breast Cancer
ARTICLE INFO
Article Type
Original ResearchAuthors
Fathollahi Shoorabeh F. (*)Tarverdyzadeh B. (1)
Aminbaksahayesh S. (2)
(*) Sport Physiology Department, Literature & Humanities Faculty, Shahrekord University, Shahrekord, Iran
(1) Sport Physiology Department, Graduate Studies Faculty, Bushehr Branch, Islamic Azad University, Bushehr, Iran
(2) Sport Physiology Department, Physical Education & Sport Sciences Faculty, ehran Center Branch, Islamic Azad University, Tehran, Iran
Correspondence
Address: Sport Physiology Department, Literature & Humanities Faculty, Shahrekord University, Km2 Saman Road, Shahrekord, IranPhone: -
Fax: -
f.fathollahi1363@gmail.com
Article History
Received: August 7, 2016Accepted: May 3, 2016
ePublished: September 8, 2017
ABSTRACT
Aims
Breast cancer is the most common cancer among women that usually
begins with abnormal growth and division of different breast cells. There is
some evidence that there is an inverse relationship between levels of
antioxidants and the risk of breast cancer. The purpose of this study was to
investigate the effect of 8 weeks resistance training on some
antioxidant/oxidative indexes in postmenopausal women with breast cancer.
Materials & Methods In this semi-experimental study, in 2014, 30 postmenopausal women with breast cancer in Khorramabad city were selected by available sampling method and randomly divided into 2 groups: experimental group (n=16) and control group (n=14). The experimental group performed resistance training for 8 weeks, which started from 30% 1RM (one repetition maximum) and reached 45-50% 1RM at the end of the eighth week. Blood samples were taken from subjects for the measurement of superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA) serum levels, 48 hours before and after the training protocol. Data were analyzed by SPSS 19 software using independent t-test and dependent t-test.
Findings After performing 8 weeks of resistance training, serum levels of SOD and GPX significantly increased and MDA levels decreased significantly (p<0.05), but changes in control group were not significant (p>0.05).
Conclusion Resistance training for 8 weeks increases antioxidant indexes and decreases oxidative indexes in postmenopausal women with breast cancer.
Materials & Methods In this semi-experimental study, in 2014, 30 postmenopausal women with breast cancer in Khorramabad city were selected by available sampling method and randomly divided into 2 groups: experimental group (n=16) and control group (n=14). The experimental group performed resistance training for 8 weeks, which started from 30% 1RM (one repetition maximum) and reached 45-50% 1RM at the end of the eighth week. Blood samples were taken from subjects for the measurement of superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA) serum levels, 48 hours before and after the training protocol. Data were analyzed by SPSS 19 software using independent t-test and dependent t-test.
Findings After performing 8 weeks of resistance training, serum levels of SOD and GPX significantly increased and MDA levels decreased significantly (p<0.05), but changes in control group were not significant (p>0.05).
Conclusion Resistance training for 8 weeks increases antioxidant indexes and decreases oxidative indexes in postmenopausal women with breast cancer.
Keywords:
Breast Cancer,
Resistance Training,
Malondialdehyde (MDA) ,
Superoxide Dismutase (SOD) ,
Glutathione Peroxidase (GPX),
CITATION LINKS
[1]Kazemi AR, Eisanezhad A, Koushesh A, Farahbakhsh E, Ghanbarzade M. The effects of six weeks of aerobic interval training and use of tamoxifen on the levels of IL-6 and IL-10 tumor-bearing mice tumor breast cancer. Iran J Breast Dis. 2014;7(4):15-22. [Persian]
[2]Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. Cancer J Clin. 2016;66(1):7-30.
[3]Ascensao A, Oliveira PJ, Magalhaes J. Exercise as a beneficial adjunct therapy during doxorubicin treatment-role of mitochondria in cardioprotection. Int J Cardiol. 2012;156(1):4-10.
[4]Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, et al. Doxorubicin: The good, the bad and the ugly effect. Curr Med Chem. 2009;16(25):3267-85.
[5]Simoncikova P, Ravingerova T, Barancik M. The effect of chronic doxorubicin treatment on mitogen-activated protein kinases and heat stress proteins in rat hearts. Physiol Res. 2008;57(Suppl 2):s97-102.
[6]Ascensao A, Magalhaes J, Soares J, Ferreira R, Neuparth M, Marques F, et al. Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice. Int J Cardiol. 2005;100(3):451-60.
[7]Bayer M, Paulsen G, Ugelstad I, Hallen J, Kalhovde J, Raastad T. Relocalization and upregulation of hsp70 after muscle damaging eccentric exercise. 11th Annual Congress of the European College of Cport Science. Lausanne/ Switzerland: University of Bern, University of Lausanne, École Polytechnique Fédérale de Lausanne and the Swiss Society of Sports Medicine; 2006.
[8]Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS. Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. J Clin Invest. 1992;89(5):1685-9.
[9]Ascensao A, Magalhaes J, Soares J, Oliveira J, Duarte J. Exercise and cardiac oxidative stress. Rev Port Cardiol. 2003;22(5):651-78.
[10]Atalay M, Oksala NK, Laaksonen DE, Khanna S, Nakao C, Lappalainen J, et al. Exercise training modulates heat shock protein response in diabetic rats. J Appl Physiol. 2004;97(2):605-11.
[11]Berthiaume JM, Wallace KB. Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell biol Toxicol. 2007;23(1):15-25.
[12]Hydock DS, Lien CY, Schneider CM, Hayward R. Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction. Med Sci Sports Exerc. 2008;40(5):808-17.
[13]Bowles DK. Curing the cure: Utilizing exercise to limit cardiotoxicity. Med Sci Sports Exerc. 2008;40(5):806-7.
[14]Jakovljevic VLi, Zlatkovic M, Cubrilo D, Pantic I, Djuric DM. The effects of progressive exercise on cardiovascular function in elite athletes: Focus on oxidative stress. Acta Physiol Hung. 2011;98(1):51-8.
[15]Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Ha S, et al. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol. 2001;84(1-2):1-6.
[16]Hatao H, Oh-ishi S, Itoh M, Leeuwenburgh C, Ohno H, Ookawara T, et al. Effects of acute exercise on lung antioxidant enzymes in young and old rats. Mech Ageing Dev. 2006;127(4):384-90.
[17]Goon JA, Aini AH, Musalmah M, Anum MY, Nazaimoon WM, Ngah WZ. Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults. J Phys Act Health. 2009;6(1):43-54.
[18]Karanth J, Jeevaratnam K. Oxidative stress and antioxidant status in rat blood, liver and muscle: Effect of dietary lipid, carnitine and exercise. Int J Vitam Nutr Res. 2005;75(5):333-9.
[19]Marsh SA, Laursen PB, Coombes JS. Effects of antioxidant supplementation and exercise training on erythrocyte antioxidant enzymes. Int J Vitam Nutr Res. 2006;76(5):324-31.
[20]Fhathollahi Shoorabeh F, Dabidiroshan V, Sheikhsaraf B, Nuri R. Investigating the effects of regular resistance training and prostatic massage on proinflammatory markers and serum prostate-specific antigen levels in males with prostate cancer. Middle East J Rehabil Health Stud. 2016;3(1):e33651.
[21]Billingham ME, Mason JW, Bristow MR, Daniels JR. Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat Rep. 1978;62(6):865-72.
[22]Monti E, Prosperi E, Supino R, Bottiroli G. Free radicaldependent DNA lesions are involved in the delayed cardiotoxicity induced by Adriamycin in the rat. Anticancer Res. 1995;15(1):193-7.
[23]Bristow MR, Sageman WS, Scott RH, Billingham ME, Bowden RE, Kernoff RS, et al. Acute and chronic cardiovascular effects of doxorubicin in the dog: The cardiovascular pharmacology of drug-induced histamine release. J Cardiovasc Pharmacol. 1980;2(5):487-515.
[24]Tong J, Ganguly PK, Singal PK. Myocardial adrenergic changes at two stages of heart failure due to Adriamycin treatment in rats. Am J Physiol. 1991;260(3 Pt 2):H909-16.
[25]Singal PK, Segstro RJ, Singh RP, Kutryk MJ. Changes in lysosomal morphology and enzyme activities during the development of adriamycin-induced cardiomyopathy. Can J Cardiol. 1985;1(2):139-47.
[26]Singal PK, Pierce GN. Adriamycin stimulates lowaffinity ca2+ binding and lipid peroxidation but depresses myocardial function. Am J Physiol. 1986; 250(3 Pt 2):h419-25.
[27]Adams AK, Best TM. The role of antioxidants in exercise and disease prevention. Phys Sports Med. 2002;30(5):37-44.
[28]Nohl H. A novel superoxide radical generator in heart mitochondria. FEBS let. 1987;214(2):269-73.
[29]Davies KJ, Doroshow JH. Redox cycling of anthracyclines by cardiac mitochondria: Anthracycline radical formation by NADPH dehydrogenous. J Biol Chem. 1986;261(7):3060-7.
[30]Eder AR, Arriaga EA. Capillary electrophoresis monitors enhancement in subcellular reactive oxygen species production upon treatment with doxorubicin. Chem Res Toxicol. 2006;19(9):1151-9.
[31]Swamy AV, Gulliaya S, Thippeswamy A, Basavaraj C.K, Donnahalli VM. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J pharmacol. 2012; 44(1):73–7.
[32]Ammar el-SM, Said SA, Suddek GM, El-Damarawy SL. Amelioration of doxorubicin-induced cardiotoxicity by deferiprone in rats. Can J Physiol Pharmacol. 2011;89(4):269-76.
[2]Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. Cancer J Clin. 2016;66(1):7-30.
[3]Ascensao A, Oliveira PJ, Magalhaes J. Exercise as a beneficial adjunct therapy during doxorubicin treatment-role of mitochondria in cardioprotection. Int J Cardiol. 2012;156(1):4-10.
[4]Carvalho C, Santos RX, Cardoso S, Correia S, Oliveira PJ, Santos MS, et al. Doxorubicin: The good, the bad and the ugly effect. Curr Med Chem. 2009;16(25):3267-85.
[5]Simoncikova P, Ravingerova T, Barancik M. The effect of chronic doxorubicin treatment on mitogen-activated protein kinases and heat stress proteins in rat hearts. Physiol Res. 2008;57(Suppl 2):s97-102.
[6]Ascensao A, Magalhaes J, Soares J, Ferreira R, Neuparth M, Marques F, et al. Endurance training attenuates doxorubicin-induced cardiac oxidative damage in mice. Int J Cardiol. 2005;100(3):451-60.
[7]Bayer M, Paulsen G, Ugelstad I, Hallen J, Kalhovde J, Raastad T. Relocalization and upregulation of hsp70 after muscle damaging eccentric exercise. 11th Annual Congress of the European College of Cport Science. Lausanne/ Switzerland: University of Bern, University of Lausanne, École Polytechnique Fédérale de Lausanne and the Swiss Society of Sports Medicine; 2006.
[8]Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS. Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. J Clin Invest. 1992;89(5):1685-9.
[9]Ascensao A, Magalhaes J, Soares J, Oliveira J, Duarte J. Exercise and cardiac oxidative stress. Rev Port Cardiol. 2003;22(5):651-78.
[10]Atalay M, Oksala NK, Laaksonen DE, Khanna S, Nakao C, Lappalainen J, et al. Exercise training modulates heat shock protein response in diabetic rats. J Appl Physiol. 2004;97(2):605-11.
[11]Berthiaume JM, Wallace KB. Adriamycin-induced oxidative mitochondrial cardiotoxicity. Cell biol Toxicol. 2007;23(1):15-25.
[12]Hydock DS, Lien CY, Schneider CM, Hayward R. Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction. Med Sci Sports Exerc. 2008;40(5):808-17.
[13]Bowles DK. Curing the cure: Utilizing exercise to limit cardiotoxicity. Med Sci Sports Exerc. 2008;40(5):806-7.
[14]Jakovljevic VLi, Zlatkovic M, Cubrilo D, Pantic I, Djuric DM. The effects of progressive exercise on cardiovascular function in elite athletes: Focus on oxidative stress. Acta Physiol Hung. 2011;98(1):51-8.
[15]Miyazaki H, Oh-ishi S, Ookawara T, Kizaki T, Toshinai K, Ha S, et al. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur J Appl Physiol. 2001;84(1-2):1-6.
[16]Hatao H, Oh-ishi S, Itoh M, Leeuwenburgh C, Ohno H, Ookawara T, et al. Effects of acute exercise on lung antioxidant enzymes in young and old rats. Mech Ageing Dev. 2006;127(4):384-90.
[17]Goon JA, Aini AH, Musalmah M, Anum MY, Nazaimoon WM, Ngah WZ. Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults. J Phys Act Health. 2009;6(1):43-54.
[18]Karanth J, Jeevaratnam K. Oxidative stress and antioxidant status in rat blood, liver and muscle: Effect of dietary lipid, carnitine and exercise. Int J Vitam Nutr Res. 2005;75(5):333-9.
[19]Marsh SA, Laursen PB, Coombes JS. Effects of antioxidant supplementation and exercise training on erythrocyte antioxidant enzymes. Int J Vitam Nutr Res. 2006;76(5):324-31.
[20]Fhathollahi Shoorabeh F, Dabidiroshan V, Sheikhsaraf B, Nuri R. Investigating the effects of regular resistance training and prostatic massage on proinflammatory markers and serum prostate-specific antigen levels in males with prostate cancer. Middle East J Rehabil Health Stud. 2016;3(1):e33651.
[21]Billingham ME, Mason JW, Bristow MR, Daniels JR. Anthracycline cardiomyopathy monitored by morphologic changes. Cancer Treat Rep. 1978;62(6):865-72.
[22]Monti E, Prosperi E, Supino R, Bottiroli G. Free radicaldependent DNA lesions are involved in the delayed cardiotoxicity induced by Adriamycin in the rat. Anticancer Res. 1995;15(1):193-7.
[23]Bristow MR, Sageman WS, Scott RH, Billingham ME, Bowden RE, Kernoff RS, et al. Acute and chronic cardiovascular effects of doxorubicin in the dog: The cardiovascular pharmacology of drug-induced histamine release. J Cardiovasc Pharmacol. 1980;2(5):487-515.
[24]Tong J, Ganguly PK, Singal PK. Myocardial adrenergic changes at two stages of heart failure due to Adriamycin treatment in rats. Am J Physiol. 1991;260(3 Pt 2):H909-16.
[25]Singal PK, Segstro RJ, Singh RP, Kutryk MJ. Changes in lysosomal morphology and enzyme activities during the development of adriamycin-induced cardiomyopathy. Can J Cardiol. 1985;1(2):139-47.
[26]Singal PK, Pierce GN. Adriamycin stimulates lowaffinity ca2+ binding and lipid peroxidation but depresses myocardial function. Am J Physiol. 1986; 250(3 Pt 2):h419-25.
[27]Adams AK, Best TM. The role of antioxidants in exercise and disease prevention. Phys Sports Med. 2002;30(5):37-44.
[28]Nohl H. A novel superoxide radical generator in heart mitochondria. FEBS let. 1987;214(2):269-73.
[29]Davies KJ, Doroshow JH. Redox cycling of anthracyclines by cardiac mitochondria: Anthracycline radical formation by NADPH dehydrogenous. J Biol Chem. 1986;261(7):3060-7.
[30]Eder AR, Arriaga EA. Capillary electrophoresis monitors enhancement in subcellular reactive oxygen species production upon treatment with doxorubicin. Chem Res Toxicol. 2006;19(9):1151-9.
[31]Swamy AV, Gulliaya S, Thippeswamy A, Basavaraj C.K, Donnahalli VM. Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats. Indian J pharmacol. 2012; 44(1):73–7.
[32]Ammar el-SM, Said SA, Suddek GM, El-Damarawy SL. Amelioration of doxorubicin-induced cardiotoxicity by deferiprone in rats. Can J Physiol Pharmacol. 2011;89(4):269-76.