@2024 Afarand., IRAN
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2018;2(2):
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2018;2(2):
Effect of Alkaloids Belong to β-Carbolines Family in Peganum Harmala on Cancer Cells
ARTICLE INFO
Article Type
Systematic ReviewAuthors
Roostaee Z. (*)(*) Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women’s Hospital, Tehran, Iran
Correspondence
Address: Sarem Women’s Hospital, Basij Square, Phase 3, Ekbatan Town, Tehran, Iran. Postal Code: 1396956111Phone: +98 (21) 44670888
Fax: +98 (21) 44670432
zrmj1394@gmail.com
Article History
Received: January 25, 2017Accepted: April 20, 2017
ePublished: June 15, 2017
ABSTRACT
Instrument & Methods
As a herb, Peganum harmala has been important in traditional medicine for a long time. Some studies have shown the inhibitory effect of many plant compounds, including alkaloids belonging to β-carboline family, on cancer cells. This plant contains important alkaloids, such as Harmaline, Harmine, Harmane, and some other components of -carboline family. The literature in this field shows that various concentrations of the alkaloids are effective in treating various diseases, including inhibition of cancer cells. The aim of this study was to introduce Peganum harmala as one of the natural potentials of Iran in relation to herbs and its pharmacological effects. In this study, the keywords Peganum harmala, pathway of betacarbolins in the human body, betacarbolins, Toxicity, and Anti-cancer were searched in Elsevier, PubMed, and Google Scholar databases and the related articles were provided. Then, in advanced search, the pharmacological effects of Peganum harmala, apoptosis, and the mechanism of analgesic effects were searched both in Persian and in English. Finally, 30 articles related to Peganum harmala in traditional medicine were downloaded, translated, and all articles underwent content analysis.
Conclusion As one of the most important herbs with valuable alkaloids belonging to the β-carboline family, African rue "Peganum harmala” can produce compounds against cancer cells that can be effective in the treatment of cancer. The review of the studies has also shown that the plant extract is effective in preventing the progression of cancer cells.
Conclusion As one of the most important herbs with valuable alkaloids belonging to the β-carboline family, African rue "Peganum harmala” can produce compounds against cancer cells that can be effective in the treatment of cancer. The review of the studies has also shown that the plant extract is effective in preventing the progression of cancer cells.
CITATION LINKS
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[14]Lamchouri F. Antitumor properties and toxicity effects of Peganum harmala L.(Zygophyllaceae). Plant Sci Today. 2014;1(4):192-5.
[15]Louis ED, Zheng W. Beta-Carboline alkaloids and essential tremor: Exploring the environmental determinants of one of the most prevalent neurological diseases. Sci World J. 2010;10:1783-94.
[16]Heshmati P, Nasehi M, Zarrindast MR. An overview of cognitive aspects of β-carbolines. J Paramed Sci. 2013;5(1):99-104.
[17]Farzin DAS, E. Effects of harmane, norharmane and harmine on apomorphine-induced pecking behavior in chick. J Mazandaran Univ Med Sci. 2009;19(70):1-8.
[18]Mahdeb N, Mayouf S, Boukhari F, Souilah S, Bouzidi A. Hemolytic effect of total alkaloids from the seeds of Peganum harmala in vitro on erythrocytes of ruminants: Sheep, cattle and goats. Asian J Plant Sci Res. 2013;3(6):53-9.
[19]Honardoost M, Solimanjahi H, Farzad R. Apoptosis: Programmed cell death. J Qazvin Univ Med Sci. 2013;17(3):48-57.
[20]Parsa N. Molecular and Cellular basis of human cancer. J Cell Tissue. 2012;2(4):365-76.
[21]Hamsa TP, Kuttan G. Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chin Med. 2011;6:11.
[22]Patel K, Gadewar M, Tripathi R, Prasad S, Patel DK. A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”. Asian Pac J Trop Biomed. 2012;2(8):660-4.
[23]Wang C, Zhang Z, Wang Y, He X. Cytotoxic indole alkaloids against human leukemia cell lines from the toxic plant Peganum harmala. Toxins (Basel). 2015;7(11):4507-18.
[24]Tallman MS, Nabhan C, Feusner JH, Rowe JM. Acute promyelocytic leukemia: Evolving therapeutic strategies. Blood. 2002;99(3):759-67.
[25]Berrougui H, Martín-Cordero C, Khalil A, Hmamouchi M, Ettaib A, Marhuenda E, et al. Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seed's in isolated rat aorta. Pharmacol Res. 2006;54(2):150-7.
[26]Hasanzadeh Tahery M, Hasanpour fard M, Rabiee N, Ghoreishe AR, Ravanbakhsh N. Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats. J Birjand Univ Med Sci. 2013;20(2):108-14.
[27]Esmaeili MH, Haghdost H, Gheybea N. Effects of opiate receptor agonists and antagonists on spontaneuse seizure activity in hipocampal slices. koomesh. 2007;9(1):27-32.
[28]Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005;100(1-2):72-9.
[2]Zaker F. Anti tumoral and differentiayion effects of alkaloids of Harmine and Harmaline on leukaemic cells treated with atra and G-CSF. Razi J Med Sci. 2004;10(38):869-75.
[3]Herraiz T, Gonzalez D, Ancín-Azpilicueta C, Arán VJ, Guillén H. Beta-Carboline alkaloids in peganum harmala and inhibition of human monoamine oxidase (MAO). Food Chem Toxicol. 2010;48(3):839-45.
[4]Asghari G, George Br. Stereospecific biotransformation of (±) phenylethyl propionate by cell cultures of peganum harmala L. Iran Biomed J. 2002;6(1):43-46.
[5]Aslam N, Wani AA, Nawchoo IA, Bhat MA. Distribution and medicinal importance of Peganum harmala. Int J Adv Res. 20142(2)751-5.
[6]Mahmoudian M, Jalipour H, Dardashti PS. Toxicity of peganum harmala: Review and a case report. Iran J Pharmacol Ther. 2002;1(1):1-4.
[7]Muhi-eldeen Z, Al-Shamma KJ, Al-Hussainy TM, Al-Kaissi EN, Al-Daraji AM, Ibrahim H. Acute toxicological studies on the extract of Iraqi Peganum harmala in rats. Europ J Sci Res. 2008;22(4):494-500.
[8]Bernardo C, Olival ACD, Ribeiro A, Rodrigues L, Esteves AP, Campos AM. Synthesis of beta-carboline derivatives [Internet]. Santiago: Universidade de Santiago de Compostela; 2017. [Update 2017 May 25, Cited 2017]. Avilable From: www.usc.es/congresos/ecsoc/16/hall_a_GOS/a027/index.pdf.
[9]Darabpour E, Motamedi H, Poshtkouhian Bavi A, Nejad S, Mansour S. Antibacterial activity of different parts of Peganum harmala L. growing in Iran against multi-drug resistant bacteria. EXCLI J. 2011;10:252-263.
[10]Alenajaf AAF, M%A Moghimi, A%A Mohebi, E%A Mohammad-Zadeh, M. Effect of Harmaline on seizure induced byamygdala kindling in rats. J North Khorasan Univ Med Sci. 2015;6(4):697-706.
[11]Singh AB, Chaturvedi J, Narender T, Srivastava AK. Preliminary studies on the hypoglycemic effect of Peganum harmala L. seeds ethanol extract on normal and streptozotocin induced diabetic rats. Indian J Clin Biochem. 2008;23(4):391-3.
[12]Ishida J, Wang H-K, Bastow KF, Hu C-Q, Lee K-H. Antitumor agents 201. 1 Cytotoxicity of harmine and β-carboline analogs. Bioorg Med Chem Lett. 1999;9(23):3319-24.
[13]Chen Q, Chao R, Chen H, Hou X, Yan H, Zhou S, et al. Antitumor and neurotoxic effects of novel harmine derivatives and structure‐activity relationship analysis. Int J Cancer. 2005;114(5):675-82.
[14]Lamchouri F. Antitumor properties and toxicity effects of Peganum harmala L.(Zygophyllaceae). Plant Sci Today. 2014;1(4):192-5.
[15]Louis ED, Zheng W. Beta-Carboline alkaloids and essential tremor: Exploring the environmental determinants of one of the most prevalent neurological diseases. Sci World J. 2010;10:1783-94.
[16]Heshmati P, Nasehi M, Zarrindast MR. An overview of cognitive aspects of β-carbolines. J Paramed Sci. 2013;5(1):99-104.
[17]Farzin DAS, E. Effects of harmane, norharmane and harmine on apomorphine-induced pecking behavior in chick. J Mazandaran Univ Med Sci. 2009;19(70):1-8.
[18]Mahdeb N, Mayouf S, Boukhari F, Souilah S, Bouzidi A. Hemolytic effect of total alkaloids from the seeds of Peganum harmala in vitro on erythrocytes of ruminants: Sheep, cattle and goats. Asian J Plant Sci Res. 2013;3(6):53-9.
[19]Honardoost M, Solimanjahi H, Farzad R. Apoptosis: Programmed cell death. J Qazvin Univ Med Sci. 2013;17(3):48-57.
[20]Parsa N. Molecular and Cellular basis of human cancer. J Cell Tissue. 2012;2(4):365-76.
[21]Hamsa TP, Kuttan G. Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chin Med. 2011;6:11.
[22]Patel K, Gadewar M, Tripathi R, Prasad S, Patel DK. A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine”. Asian Pac J Trop Biomed. 2012;2(8):660-4.
[23]Wang C, Zhang Z, Wang Y, He X. Cytotoxic indole alkaloids against human leukemia cell lines from the toxic plant Peganum harmala. Toxins (Basel). 2015;7(11):4507-18.
[24]Tallman MS, Nabhan C, Feusner JH, Rowe JM. Acute promyelocytic leukemia: Evolving therapeutic strategies. Blood. 2002;99(3):759-67.
[25]Berrougui H, Martín-Cordero C, Khalil A, Hmamouchi M, Ettaib A, Marhuenda E, et al. Vasorelaxant effects of harmine and harmaline extracted from Peganum harmala L. seed's in isolated rat aorta. Pharmacol Res. 2006;54(2):150-7.
[26]Hasanzadeh Tahery M, Hasanpour fard M, Rabiee N, Ghoreishe AR, Ravanbakhsh N. Effects of aqueous and ethanolic extracts of Peganum harmala L seeds on lipids profile in rats. J Birjand Univ Med Sci. 2013;20(2):108-14.
[27]Esmaeili MH, Haghdost H, Gheybea N. Effects of opiate receptor agonists and antagonists on spontaneuse seizure activity in hipocampal slices. koomesh. 2007;9(1):27-32.
[28]Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol. 2005;100(1-2):72-9.