ARTICLE INFO

Article Type

Systematic Review

Authors

Roostaee   Z. (*)






(*) Sarem Fertility & Infertility Research Center (SAFIR)‎, Sarem Women’s Hospital, Tehran, Iran

Correspondence

Address: Sarem Women’s Hospital, Basij Square, Phase 3, Ekbatan Town, Tehran, Iran. Postal Code: 1396956111‎
Phone: ‎+98 (21) 44670888‎
Fax: ‎+98 (21) 44670432‎
zrmj1394@gmail.com

Article History

Received:   January  25, 2017
Accepted:   April 20, 2017
ePublished:   June 15, 2017

ABSTRACT

Instrument & Methods As a herb, Peganum harmala has been important in traditional medicine for a long ‎time. Some studies have shown the inhibitory effect of many plant compounds, ‎including alkaloids belonging to β-carboline family, on cancer cells. This plant ‎contains important alkaloids, such as Harmaline, Harmine, Harmane, and some ‎other components of -carboline family. The literature in this field shows that ‎various concentrations of the alkaloids are effective in treating various diseases, ‎including inhibition of cancer cells. The aim of this study was to introduce ‎Peganum harmala as one of the natural potentials of Iran in relation to herbs and ‎its pharmacological effects. In this study, the keywords Peganum harmala, ‎pathway of betacarbolins in the human body, betacarbolins, Toxicity, and Anti-‎cancer were searched in Elsevier, PubMed, and Google Scholar databases and the ‎related articles were provided. Then, in advanced search, the pharmacological ‎effects of Peganum harmala, apoptosis, and the mechanism of analgesic effects ‎were searched both in Persian and in English. Finally, 30 articles related to ‎Peganum harmala in traditional medicine were downloaded, translated, and all ‎articles underwent content analysis.‎
Conclusion As one of the most important herbs with valuable alkaloids belonging to the β-‎carboline family, African rue "Peganum harmala” can produce compounds against ‎cancer cells that can be effective in the treatment of cancer. The review of the ‎studies has also shown that the plant extract is effective in preventing the ‎progression of cancer cells.‎


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