@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(4):307-312
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(4):307-312
Effect of Physical Activity on Serum Homocysteine Levels in Obese and Overweight Women
ARTICLE INFO
Article Type
Original ResearchAuthors
Soori R. (*)Choopani S. (1)
Falahian N. (2)
Ramezankhani A. (1)
(*) Exercise Physiology Department, Education & Sport Sciences Faculty, Tehran University, Tehran, Iran
(1) Exercise Physiology Department, Education & Sport Sciences Faculty, Tehran University, Tehran, Iran
(2) Exercise Physiology Department, Education & Sport Sciences Faculty, Alzahra University, Tehran, Iran
Correspondence
Address: Faculty of Physical Education and Sport Sciences, North Kargar Street, Tehran, IranPhone: +98 (21) 88351741
Fax: +98 (21) 88351741
soorirahman@yahoo.com
Article History
Received: April 21, 2016Accepted: July 2, 2016
ePublished: October 1, 2016
ABSTRACT
Aims
Recently, homocysteine has been noticed as the major pathogenesis factor of the cardiovascular diseases. The aim of the study was to investigate the effects of physical activities on the serum homocysteine levels, as well as other cardiovascular risk factors in either obese or overweight women.
Materials & Methods In the controlled pretest-posttest semi-experimental study, 18 women referred to the Alzahra sport complexes in districts 3 and 4 of Tehran were studied in 2015. The subjects were selected via random sampling method and randomly divided into two groups; physical activity and control groups. And the intervention program was conducted in the former, while the latter received no intervention. The exercise protocol consisted of 10-week (5 sessions a week) stretching exercises and aerobic activities (60 to 75% of the maximum heart beat). The serum homocystein level and lipids were measured both at the start and 48 hours after the exercises. Data was analyzed by SPSS 16 software using paired T and independent T tests.
Findings After the exercises, the mean serum homocysteine level in physical activity group significantly decreased than control group (p=0.001). Nevertheless, the difference between the lipid levels of physical activity and control groups was not significant (p>0.05).
Conclusion Reducing the serum homocysteine concentration, 10-week physical activity might also reduce the risk factors of cardiovascular diseases in either obese or overweight women.
Materials & Methods In the controlled pretest-posttest semi-experimental study, 18 women referred to the Alzahra sport complexes in districts 3 and 4 of Tehran were studied in 2015. The subjects were selected via random sampling method and randomly divided into two groups; physical activity and control groups. And the intervention program was conducted in the former, while the latter received no intervention. The exercise protocol consisted of 10-week (5 sessions a week) stretching exercises and aerobic activities (60 to 75% of the maximum heart beat). The serum homocystein level and lipids were measured both at the start and 48 hours after the exercises. Data was analyzed by SPSS 16 software using paired T and independent T tests.
Findings After the exercises, the mean serum homocysteine level in physical activity group significantly decreased than control group (p=0.001). Nevertheless, the difference between the lipid levels of physical activity and control groups was not significant (p>0.05).
Conclusion Reducing the serum homocysteine concentration, 10-week physical activity might also reduce the risk factors of cardiovascular diseases in either obese or overweight women.
CITATION LINKS
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[6]Seo DY, Lee SR, Kim HK, Baek YH, Kwak YS, Ko TH, et al. Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women. Nutr Res Pract. 2012;6(3):226-31.
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[12]Mir E, Fathei M, Sayeedi M. The effect of eight weeks combined training (aerobic-resistance) on homocysteine, C - reactive protein and lipid profile in inactive elderly men. Med J Tabriz Univ Med Sci. 2015;36(6):80-6. [Persian]
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[14]Boreham CA, Kennedy RA, Murphy MH, Tully M, Wallace WF, Young I. Training effects of short bouts of stair climbing on cardiorespiratory fitness, blood lipids, and homocysteine in sedentary young women. Br J Sports Med. 2005;39(9):590-3.
[15] Tartibian B, Godrat-Garebagh Z, Gaeini A, Tolouei-Azar J. Influence of 9-weeks aerobic exercise and multivitamin supplement on inflammation biomarkers as cardiovascular risk factor in non-athletic obese women. Zahedan J Res Med Sci. 2013;15(3):30-5. [Persian]
[16]Thomas NE, Williams RD. Inflammatory factors, physical activity, and physical fitness in young people. Scand J Med Sci Sports. 2008;18(5):543-56.
[17]Beavers KM, Beavers DP, Bowden RG, Wilson RL, Gentile M. Omega-3 fatty acid supplementation and total homocysteine levels in end-stage renal disease patients. Nephrol. 2008;13(4):284-8.
[18]Choi KM, Kim TN, Yoo HJ, Lee KW, Cho GJ, Hwang TG, et al. Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women. Clin Endocrinol. 2009;70(4):569-74.
[19]Dehghan SH, Sharifi GH, Faramarzi M. The effect of eight week low impact rhythmic aerobic training on total plasma homocysteine concentration in older non-athlete women. J Mzandaran Univ Med Sci. 2009;19(72):54-9. [Persian]
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[22]Okura T, Rankinen T, Gagnon J, Lussier-Cacan S, Davignon J, Leon AS, et al. Effects of regular Exercise on homocysteine concentrations: the heritage family study. Eur J Appl Physiol. 2006;98(4):394-401.
[23]Antunes HK, DeMello MT, deAquino L, Santos-Galduróz RF, Galduróz JCF, Aquino Lemos V, et al. Aerobic physical exercise improved the cognitive function of elderly males but did not modify their blood homocysteine levels. Dement Geriatr Cogn Disord Extra. 2015;5(1):13-24.
[24]Rousseau AS, Robin S, Roussel AM, Ducros V, Margaritis I. Plasma homocysteine is related to folate intake but not training status. Nutr Metab Cardiovasc Dis. 2005;15(2):125-33.
[25]Nikbakht HA, AmirTash AM, Gharoni H, Zafari A. Correlation of physical activity with serum fibrinogen and homocysteine concentration in active, sedentary and with cad males. Olympics. 2007;15(2):71-80. [Persian]
[26]Bahram ME, Najjarian M, Sayyah M, Mojtahedi H. The effect of an eight-week aerobic exercise program on the homocysteine level and VO2max in young non-athlete men. Fayz. 2013;17(2):149-56. [Persian]
[27]Subaşı SS, Gelecek N, Aksakoğlu G, Omret M. Effects of two different exercise trainings on plasma homocysteine levels and other cardiovascular disease risks. Türk J Biochem. 2012;37(3):303-14.
[2]Clarke R, Halsey J, Bennett D, Lewington S. Homocysteine and vascular disease: Review of published results of the homocysteine-lowering trials. J Inherit Metab Dis. 2011;34(1):83-91.
[3]Kuo HK, Sorond FA, Chen JH, Hashmi A, Milberg WP, Lipsitz LA. The role of homocysteine in multisystem age-related problems: A systematic review. J Gerontol a Biol Sci Med Sci. 2005;60(9):1190-201.
[4]Mei W, Rong Y, Jinming L, Yongjun L, Hui Z. Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials. Int J Clin Pract. 2010;64(2):208 –15.
[5]Naess H, Nyland H, Idicula T, Waje-Andreassen U. C-reactive protein and homocysteine predict long-term mortality in young ischemic stroke patients. J Stroke Cerebrovasc Dis. 2013;22(8):e435-40.
[6]Seo DY, Lee SR, Kim HK, Baek YH, Kwak YS, Ko TH, et al. Independent beneficial effects of aged garlic extract intake with regular exercise on cardiovascular risk in postmenopausal women. Nutr Res Pract. 2012;6(3):226-31.
[7]Bastien M, Poirier P, Lemieeux I, Després JP. Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis. 2014;56(4):369-81.
[8]Pattyn N, Cornelissen VA, Eshghi SR, Vanhees L. The effect of exercise on the cardiovascular risk factors constituting the metabolic syndrome. Sports Med. 2013;43(2):121-33.
[9]Look AHEAD Research Group, Wing RR. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: Four-year results of the Look AHEAD trial. Arch Intern Med. 2010;170(17):1566-75.
[10]Naghii MR, Aref MA, Almadadi M, Hedayati M. Effect of regular physical activity on non-lipid (novel) cardiovascular risk factors. Int J Occup Med Environ Health. 2011;24(4):380-90.
[11]Gelecek N, Teoman N, Ozdirenc M, Pinar L, Akan P, Bediz C, et al. Influences of acute and chronic aerobic exercise on the plasma homocysteine level. Ann Nutr Metab. 2007;51(1):53-8.
[12]Mir E, Fathei M, Sayeedi M. The effect of eight weeks combined training (aerobic-resistance) on homocysteine, C - reactive protein and lipid profile in inactive elderly men. Med J Tabriz Univ Med Sci. 2015;36(6):80-6. [Persian]
[13]Neuman JC, Albright KA, Schalinske KL. Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model. Nutr Res. 2013;33(6):487-93.
[14]Boreham CA, Kennedy RA, Murphy MH, Tully M, Wallace WF, Young I. Training effects of short bouts of stair climbing on cardiorespiratory fitness, blood lipids, and homocysteine in sedentary young women. Br J Sports Med. 2005;39(9):590-3.
[15] Tartibian B, Godrat-Garebagh Z, Gaeini A, Tolouei-Azar J. Influence of 9-weeks aerobic exercise and multivitamin supplement on inflammation biomarkers as cardiovascular risk factor in non-athletic obese women. Zahedan J Res Med Sci. 2013;15(3):30-5. [Persian]
[16]Thomas NE, Williams RD. Inflammatory factors, physical activity, and physical fitness in young people. Scand J Med Sci Sports. 2008;18(5):543-56.
[17]Beavers KM, Beavers DP, Bowden RG, Wilson RL, Gentile M. Omega-3 fatty acid supplementation and total homocysteine levels in end-stage renal disease patients. Nephrol. 2008;13(4):284-8.
[18]Choi KM, Kim TN, Yoo HJ, Lee KW, Cho GJ, Hwang TG, et al. Effect of exercise training on A-FABP, lipocalin-2 and RBP4 levels in obese women. Clin Endocrinol. 2009;70(4):569-74.
[19]Dehghan SH, Sharifi GH, Faramarzi M. The effect of eight week low impact rhythmic aerobic training on total plasma homocysteine concentration in older non-athlete women. J Mzandaran Univ Med Sci. 2009;19(72):54-9. [Persian]
[20]Kelley G, Kelley K. Effects of exercise and physical activity on homocysteine in adults: A meta-analysis of randomized controlled trials. J Exerc Physiol. 2008;11(5):12-23.
[21]Mohammadi HR, Khoshnam E, Jahromi MK, Khoshnam MS, Karampour E. The effect of 12-week of aerobic training on homocysteine, lipoprotein a and lipid profile levels in sedentary middle-aged men. Int J Prev Med. 2014;5(8):1060-6.
[22]Okura T, Rankinen T, Gagnon J, Lussier-Cacan S, Davignon J, Leon AS, et al. Effects of regular Exercise on homocysteine concentrations: the heritage family study. Eur J Appl Physiol. 2006;98(4):394-401.
[23]Antunes HK, DeMello MT, deAquino L, Santos-Galduróz RF, Galduróz JCF, Aquino Lemos V, et al. Aerobic physical exercise improved the cognitive function of elderly males but did not modify their blood homocysteine levels. Dement Geriatr Cogn Disord Extra. 2015;5(1):13-24.
[24]Rousseau AS, Robin S, Roussel AM, Ducros V, Margaritis I. Plasma homocysteine is related to folate intake but not training status. Nutr Metab Cardiovasc Dis. 2005;15(2):125-33.
[25]Nikbakht HA, AmirTash AM, Gharoni H, Zafari A. Correlation of physical activity with serum fibrinogen and homocysteine concentration in active, sedentary and with cad males. Olympics. 2007;15(2):71-80. [Persian]
[26]Bahram ME, Najjarian M, Sayyah M, Mojtahedi H. The effect of an eight-week aerobic exercise program on the homocysteine level and VO2max in young non-athlete men. Fayz. 2013;17(2):149-56. [Persian]
[27]Subaşı SS, Gelecek N, Aksakoğlu G, Omret M. Effects of two different exercise trainings on plasma homocysteine levels and other cardiovascular disease risks. Türk J Biochem. 2012;37(3):303-14.