@2024 Afarand., IRAN

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ISSN: 2251-8215    Sarem Journal of Reproductive Medicine 2017;1(4):

Information & Methods Hemolysis, Elevated Liver enzymes, and Low Platelet count (HELLP) syndrome is ‎one of the common and important complications of pregnancy. Also, Acute Fatty ‎Acid Liver of Pregnancy (AFLP) is a very severe and less common complication in ‎pregnancy with high mortality rate. In Fatty Acids Oxidation Defects (FAODs), ‎patients cannot metabolize fatty acids. Asymptomatic carrier mothers are at ‎higher risk for one of these diseases. A 33-year-old pregnant woman at the 22nd ‎week of pregnancy with a 2-day history of abdominal pain, headache, blurred ‎vision, and vomiting was referred to the hospital emergency room and ‎hospitalized there. The patient was an agitated at the time of admission. She was ‎worked up with the impairment of sensation, jaundice, high blood pressure, and ‎proteinuria with the suspicion of HELLP syndrome. The patient had high LDH, ‎high SGOT levels, and very low platelets, and despite the onset of medical and ‎preventive measures, the embryo was aborted 24 hours later. In later maternal ‎assessments, a genetic-metabolic disorder was diagnosed from the group of ‎oxidation disorders of fatty acids.‎
Conclusion FAODs in mitochondria are a group of genetic and metabolic diseases that are ‎transmitted through the autosomal recessive inheritance pattern. These disorders ‎in mothers who are heterozygous for this disease have important side effects such ‎as severe preeclampsia, AFLP, and HELLP syndrome. These diseases are ‎relatively common and should be taken into account in pregnancies at risk.‎