@2024 Afarand., IRAN
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2019;3(1):5-8
ISSN: 2251-8215 Sarem Journal of Reproductive Medicine 2019;3(1):5-8
Comparison of the Fertility Rates of Intra-Cytoplasmic Sperm Injections between Treated Endometriosis and Healthy Women
ARTICLE INFO
Article Type
Original ResearchAuthors
Alirezaei M. (1)Saremi A. (*1)
Sh. Rouzrokh (2)
Pooladi A. (1)
(1) “Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)”, Sarem Women Hospital, Tehran, Iran
(2) Sarem Fertility & Infertility Research Center (SAFIR), Sarem Women Hospital, Tehran, Iran
Correspondence
Address: Sarem Women Hospital, Basij Square, Phase 3, Ekbatan Town, Tehran, Iran. Postal Code: 1396956111Phone: +98 (21) 44670888
Fax: +98 (21) 44670432
saremiat@yahoo.com
Article History
Received: July 23, 2017Accepted: September 25, 2017
ePublished: June 4, 2019
ABSTRACT
Aims
The women with infertility caused by endometriosis, need to use assisted reproductive technology after their treatment. The objective of this study was to evaluate fertility rate using ICSI in women with treated endometriosis compared to healthy women.
Materials & Methods In this retrospective quasi-experimental study, endometriotic women (n=150) who were treated by endometriosis treatment protocol of Sarem Women’s Hospital were selected and their fertility rate was compared with that of normal women (n=150) who referred Sarem Women’s Hospital for ICSI due to obstructive azoospermia of their husbands. The data were analyzed by Spearman rank correlation coefficient, Mann-Whitney U, Fisher's exact and Chi-Square tests using SPSS 22 software.
Findings The mature oocytes number of case group was significantly lower than control group (p=0.036); however, the fertility rate did not show significant differences between groups (p=0.397). There was a reverse significant correlation between the grade of endometriosis with the total oocyte and mature oocyte counts in endometriotic patients after treatment (p=0.04 and p=0.016, respectively).
Conclusion The fertility rate using ICSI method in women after endometriosis treatment is not different from healthy women.
Materials & Methods In this retrospective quasi-experimental study, endometriotic women (n=150) who were treated by endometriosis treatment protocol of Sarem Women’s Hospital were selected and their fertility rate was compared with that of normal women (n=150) who referred Sarem Women’s Hospital for ICSI due to obstructive azoospermia of their husbands. The data were analyzed by Spearman rank correlation coefficient, Mann-Whitney U, Fisher's exact and Chi-Square tests using SPSS 22 software.
Findings The mature oocytes number of case group was significantly lower than control group (p=0.036); however, the fertility rate did not show significant differences between groups (p=0.397). There was a reverse significant correlation between the grade of endometriosis with the total oocyte and mature oocyte counts in endometriotic patients after treatment (p=0.04 and p=0.016, respectively).
Conclusion The fertility rate using ICSI method in women after endometriosis treatment is not different from healthy women.
Keywords:
Infertility ,
Embryo Implantation ,
Oocyte Retrieval,
Pregnancy Rate,
Azoospermia ,
Sperm Injections, Intracytoplasmic,
CITATION LINKS
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[2]Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009;92(1):68-74.
[3]Boni L, Tenconi S, Beretta P, Cromi A, Dionigi G, Rovera F, et al. Laparoscopic colorectal resections with transvaginal specimen extraction for severe endometriosis. Surg Oncol. 2007;16:157-60.
[4]Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: A committee opinion. Fertil Steril. 2012;98(3):591-8.
[5]Kuivasaari P, Hippeläinen M, Anttila M, Heinonen S. Effect of endometriosis on IVF/ICSI outcome: Stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod. 2005;20(11):3130-5.
[6]Kokcu A. Possible effects of endometriosis-related immune events on reproductive function. Arch Gynecol Obstet. 2013;287(6):1225-33.
[7]Bulletti C, Elisabetta Coccia M, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27(8):441-7.
[8]Saremi A. Treatment of endometriosis as a priority before art. Int J Gynecol Obstet. 2000;70(51):A49.
[9]Saremi AT, Eshkevari AL, Pour KE, Pooladi A. Efficacy analysis of an experience on development of the combination therapy protocol for endometriosis management. Sci Res. 2016;7(1):31-40.
[10]Saremi A, Pooladi A. Endometriosis management; A survey on medical & laparoscopic treatment. Sarem J Med. 2016;4(16):9-15.
[11] Hamdan M, Dunselman G, Li T, Cheong Y. The impact of endometrioma on IVF/ICSI outcomes: A systematic review and meta-analysis. Hum Reprod Update. 2015;21(6):809-25.
[12]Reinblatt SL, Ishai L, Shehata F, Son WY, Tulandi T, Almog B. Effects of ovarian endometrioma on embryo quality. Fertil Steril. 2011;95(8):2700-2.
[13]Verma S. Evidence linked treatment for endometriosis-associated infertility. Apollo Med. 2012;9(3):184-92.
[14]Rajani S, Chattopadhyay R, Goswami SK, Ghosh S, Sharma S, Chakravarty B. Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome. J Hum Reprod Sci. 2012;5(2):187-93.
[2]Meuleman C, Vandenabeele B, Fieuws S, Spiessens C, Timmerman D, D'Hooghe T. High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners. Fertil Steril. 2009;92(1):68-74.
[3]Boni L, Tenconi S, Beretta P, Cromi A, Dionigi G, Rovera F, et al. Laparoscopic colorectal resections with transvaginal specimen extraction for severe endometriosis. Surg Oncol. 2007;16:157-60.
[4]Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: A committee opinion. Fertil Steril. 2012;98(3):591-8.
[5]Kuivasaari P, Hippeläinen M, Anttila M, Heinonen S. Effect of endometriosis on IVF/ICSI outcome: Stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod. 2005;20(11):3130-5.
[6]Kokcu A. Possible effects of endometriosis-related immune events on reproductive function. Arch Gynecol Obstet. 2013;287(6):1225-33.
[7]Bulletti C, Elisabetta Coccia M, Battistoni S, Borini A. Endometriosis and infertility. J Assist Reprod Genet. 2010;27(8):441-7.
[8]Saremi A. Treatment of endometriosis as a priority before art. Int J Gynecol Obstet. 2000;70(51):A49.
[9]Saremi AT, Eshkevari AL, Pour KE, Pooladi A. Efficacy analysis of an experience on development of the combination therapy protocol for endometriosis management. Sci Res. 2016;7(1):31-40.
[10]Saremi A, Pooladi A. Endometriosis management; A survey on medical & laparoscopic treatment. Sarem J Med. 2016;4(16):9-15.
[11] Hamdan M, Dunselman G, Li T, Cheong Y. The impact of endometrioma on IVF/ICSI outcomes: A systematic review and meta-analysis. Hum Reprod Update. 2015;21(6):809-25.
[12]Reinblatt SL, Ishai L, Shehata F, Son WY, Tulandi T, Almog B. Effects of ovarian endometrioma on embryo quality. Fertil Steril. 2011;95(8):2700-2.
[13]Verma S. Evidence linked treatment for endometriosis-associated infertility. Apollo Med. 2012;9(3):184-92.
[14]Rajani S, Chattopadhyay R, Goswami SK, Ghosh S, Sharma S, Chakravarty B. Assessment of oocyte quality in polycystic ovarian syndrome and endometriosis by spindle imaging and reactive oxygen species levels in follicular fluid and its relationship with IVF-ET outcome. J Hum Reprod Sci. 2012;5(2):187-93.