@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(4):329-336
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(4):329-336
Long-Term Effect of High-Intensity Interval and Concurrent Exercise on Blood Coagulation and Fibrinolysis Parameters in Non-Athlete Healthy Young Men
ARTICLE INFO
Article Type
Original ResearchAuthors
Sobhani V. (1)Mohammadi M.T. (2)
Shirvani H. (1)
Amini A. (*)
(*) Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
(1) Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
(2) Physiology & Biophysics Department, Medicine Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran
Correspondence
Address: Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Shahid Nosrati Alley, South Sheikh Bahaei Avenue, Mollasadra Street, Tehran, Iran. Post Box: 19395-5487Phone: +98 (87) 36226055
Fax: +98 (21) 88600030
amir.amini466@gmail.com
Article History
Received: January 8, 2015Accepted: June 11, 2016
ePublished: October 1, 2016
ABSTRACT
Aims
Following the sport activities, the blood homeostasis system, being affected by fibrinolysis and coagulation factors, is changed. The aim of this study was to investigate the effects of high-intensity interval and concurrent (aerobic-resistance) long-term sport courses on the blood fibrinolysis and coagulation parameters in healthy non-athlete young persons.
Materials & Methods In the semi-experimental study, 30 healthy non-athlete young men were studied in Saqez in 2014. The subjects, selected via simple available sampling method, were randomly divided into three groups including concurrent (aerobic-resistance) trainings, high-intensity interval trainings, and control groups. 8-week trainings (3 times a week) were conducted in both concurrent and high-intensity interval groups. Blood sampling was done before the first session and 30 minutes after the last training session. Data was analyzed by SPSS 19 software using dependent T, one-way ANOVA, and Tukey’s post-hoc tests.
Findings After the training intervention, the number of platelits and the fibrinogen level significantly decreased in concurrent group. In addition, prothrombin time in high-intensity interval group and the D-dimer level in both training groups significantly increased (p<0.05). The D-dimer concentrations in control and high-intensity interval groups were significantly different. In addition, the number of platelets in concurrent group was significantly different from both control and high-intensity interval groups (p<0.05).
Conclusion 8-week high-intensity interval and concurrent trainings reduce the promoter coagulation activity in the helthy non-athlete young men, while increase the fibrinolytic activity.
Materials & Methods In the semi-experimental study, 30 healthy non-athlete young men were studied in Saqez in 2014. The subjects, selected via simple available sampling method, were randomly divided into three groups including concurrent (aerobic-resistance) trainings, high-intensity interval trainings, and control groups. 8-week trainings (3 times a week) were conducted in both concurrent and high-intensity interval groups. Blood sampling was done before the first session and 30 minutes after the last training session. Data was analyzed by SPSS 19 software using dependent T, one-way ANOVA, and Tukey’s post-hoc tests.
Findings After the training intervention, the number of platelits and the fibrinogen level significantly decreased in concurrent group. In addition, prothrombin time in high-intensity interval group and the D-dimer level in both training groups significantly increased (p<0.05). The D-dimer concentrations in control and high-intensity interval groups were significantly different. In addition, the number of platelets in concurrent group was significantly different from both control and high-intensity interval groups (p<0.05).
Conclusion 8-week high-intensity interval and concurrent trainings reduce the promoter coagulation activity in the helthy non-athlete young men, while increase the fibrinolytic activity.
CITATION LINKS
[1]Fuster V, Stein B, Ambrose J, Badimon L, Badimon J, Chesebro J. Atherosclerotic plaque rupture and thrombosis. Evolving concepts. Circ. 1990;82(3 Suppl):1147-59.
[2]Pate RR, Davis MG, Robinson TN, Stone EJ, McKenzie TL, Young JC, et al. Promoting physical activity in children and youth a leadership role for schools: A scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism (Physical Activity Committee) in collaboration with the councils on Cardiovascular Disease in the Young and Cardiovascular Nursing. Circ. 2006;114(11):1214-24.
[3]Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, et al. Resistance exercise in individuals with and without cardiovascular disease benefits, rationale, safety, and prescription an advisory from the committee on exercise, rehabilitation, and prevention, council on clinical cardiology, American Heart Association. Circ. 2000;101(7):828-33.
[4]Bakhtiari K, Meijers JC, de Jonge E, Levi M. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med. 2004;32(12):2416-21.
[5]Jahangard T, Torkaman G, Ghoosheh B, Hedayati M, Dibaj A. The effect of short-term aerobic training on coagulation and fibrinolytic factors in sedentary healthy postmenopausal women. Matur. 2009;64(4):223-7.
[6]Kordi MR, Ahmadizad S, Nikokheslat S. The effect of 12 weeks resistance training on the levels of rest hemorheology variables young men. Sports Res Sci. 2010;27(5):105-22. [Persian]
[7]Kahraman S, Demirkan F, Bediz C, Alacacioglu I, Aksu I. The effect of exercise on fibrinolytic and coagulation systems in healthy volunteers. J Thromb Haemost. 2007;5(Suppl 2):P-S-362.
[8]Amini A, Kordi MR, Gaini AA, Ahmadi A, Veysi K. Effect of resistance exercise on coagulation and fibrinolytic factors in inactive aged men. Horizon Med Sci. 2012;18(3):103-8. [Persian]
[9]Van den Burg P, Hospers JE, Mosterd WL, Bouma BN, Huisveld IA. Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products. J Appl Physiol. 2000;88(5):1558-64.
[10]Bobeuf F, Labonté M, Khalil A, Dionne IJ. Effect of resistance training on hematological blood markers in older men and women: A pilot study. Curr Gerontol Geriat Res. 2009;2009:1-4.
[11]Amini A, Kordi MR, Gaini AA, Ahmadi A, Ayoubian H, Lahoorpour F. The effects of aerobic exercises on coagulation and fibrinolytic factors in inactive aged men. J Kurdistan Univ Med Sci. 2011;15(4):25-32. [Persian]
[12]Zanettini R, Bettega D, Agostoni O, Ballestra B, del Rosso G, di Michele R, et al. Exercise training in mild hypertension: effects on blood pressure, left ventricular mass and coagulation factor VII and fibrinogen. Cardiol. 1997;88(5):468-73.
[13]Glaister M, Hauck H, Abraham CS, Merry KL, Beaver D, Woods B, et al. Familiarization, reliability, and comparability of a 40-m maximal shuttle run test. J Sports Sci Med. 2009;8(1):77-82.
[14]Wang JS, Jen CJ, Chen HI. Effects of exercise training and deconditioning on platelet function in men. Arterioscler Thromb Vasc Biol. 1995;15(10):1668-74.
[15]Mutanen M, Freese R. Fats, lipids and blood coagulation. Curr Opin Lipidol. 2001;12(1):25-9.
[16]Alzahrani SH, Ajjan RA. Coagulation and fibrinolysis in diabetes. Diab Vasc Dis Res. 2010;7(4):260-73.
[17]Smith JE, Garbutt G, Lopes P, Pedoe DT. Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department. Br J Sports Med. 2004;38(3):292-4.
[18]Duncan BB, Schmidt MI, Chambles LE, Folsom AR, Charpenter M, Heiss G. Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults--the ARTC study: Atherosclerosis risk in communities. Obes Res. 2000;8(4):279-86.
[19]Kupchak BR, Volk BM, Kunces LJ, Kraemer WJ, Hoffman MD, Phinney SD, et al. Alterations in coagulatory and fibrinolytic systems following an ultra-marathon. Eur J Appl Physiol. 2013;113(11):2705-12.
[20]Parker BA, Augeri AL, Capizzi JA, Ballard KD, Kupchak BR, Volek JS, et al. Effect of marathon run and air travel on pre-and post-run soluble d-dimer, microparticle procoagulant activity, and p-selectin levels. Am J Cardiol. 2012;109(10):1521-5.
[21]Posthuma JJ, van der Meijden PE, ten Cate H, Spronk HM. Short-and Long-term exercise induced alterations in haemostasis: A review of the literature. Blood Rev. 2015;29(3):171-8.
[22]Heber S, Volf I. Effects of physical (in) activity on platelet function. Biomed Res Int. 2015;2015:1-11.
[23]Ahmadizad S, El-Sayed MS, MacLaren DP. Responses of platelet activation and function to a single bout of resistance exercise and recovery. Clin Hemorheol Microcirc. 2006;35(1-2):159-68.
[24]Ahmadizad S, El-Sayed MS. The effects of graded resistance exercise on platelet aggregation and activation. Med Sci Sports Exerc. 2003;35(6):1026-32.
[25]Soleimani M, Amini A, Ahmadi A, Atashak S, Mehdivand A, Kawsari E, et al. Effect of short-term supplementation of cocoa on platelet factors (Plt, MPV, PDW) of athlete male’s blood after an exhaustive aerobic exercise. J Kurdistan Uni Med Sci. 2013;18(4):18-27. [Persian]
[26]San Jose MCZ, Apaga NEP, Florento L, Gan RN. Effects of aerobic exercise and training on coagulation, platelet aggregation, and plasma lipids. Vasc Dis Prev. 2005;2(2):145-50.
[27]Menzel K, Hilberg T. Blood coagulation and fibrinolysis in healthy, untrained subjects: Effects of different exercise intensities controlled by individual anaerobic threshold. Eur J Appl Physiol. 2011;111(2):253-60.
[28]Hilberg T, Gläser D, Reckhart C, Prasa D, Stürzebecher J, Gabriel HH. Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold. Eur J Appl Physiol. 2003;90(5-6):639-42.
[29]Piccone G, Fazio F, Giudice E, Grasso F, Caola G. Exercise-induced change in clotting times and fibrinolytic activity during official 1600 and 2000 meters trot races in standard horses. Acta Vet Brno. 2005;74(4):509-14.
[2]Pate RR, Davis MG, Robinson TN, Stone EJ, McKenzie TL, Young JC, et al. Promoting physical activity in children and youth a leadership role for schools: A scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism (Physical Activity Committee) in collaboration with the councils on Cardiovascular Disease in the Young and Cardiovascular Nursing. Circ. 2006;114(11):1214-24.
[3]Pollock ML, Franklin BA, Balady GJ, Chaitman BL, Fleg JL, Fletcher B, et al. Resistance exercise in individuals with and without cardiovascular disease benefits, rationale, safety, and prescription an advisory from the committee on exercise, rehabilitation, and prevention, council on clinical cardiology, American Heart Association. Circ. 2000;101(7):828-33.
[4]Bakhtiari K, Meijers JC, de Jonge E, Levi M. Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med. 2004;32(12):2416-21.
[5]Jahangard T, Torkaman G, Ghoosheh B, Hedayati M, Dibaj A. The effect of short-term aerobic training on coagulation and fibrinolytic factors in sedentary healthy postmenopausal women. Matur. 2009;64(4):223-7.
[6]Kordi MR, Ahmadizad S, Nikokheslat S. The effect of 12 weeks resistance training on the levels of rest hemorheology variables young men. Sports Res Sci. 2010;27(5):105-22. [Persian]
[7]Kahraman S, Demirkan F, Bediz C, Alacacioglu I, Aksu I. The effect of exercise on fibrinolytic and coagulation systems in healthy volunteers. J Thromb Haemost. 2007;5(Suppl 2):P-S-362.
[8]Amini A, Kordi MR, Gaini AA, Ahmadi A, Veysi K. Effect of resistance exercise on coagulation and fibrinolytic factors in inactive aged men. Horizon Med Sci. 2012;18(3):103-8. [Persian]
[9]Van den Burg P, Hospers JE, Mosterd WL, Bouma BN, Huisveld IA. Aging, physical conditioning, and exercise-induced changes in hemostatic factors and reaction products. J Appl Physiol. 2000;88(5):1558-64.
[10]Bobeuf F, Labonté M, Khalil A, Dionne IJ. Effect of resistance training on hematological blood markers in older men and women: A pilot study. Curr Gerontol Geriat Res. 2009;2009:1-4.
[11]Amini A, Kordi MR, Gaini AA, Ahmadi A, Ayoubian H, Lahoorpour F. The effects of aerobic exercises on coagulation and fibrinolytic factors in inactive aged men. J Kurdistan Univ Med Sci. 2011;15(4):25-32. [Persian]
[12]Zanettini R, Bettega D, Agostoni O, Ballestra B, del Rosso G, di Michele R, et al. Exercise training in mild hypertension: effects on blood pressure, left ventricular mass and coagulation factor VII and fibrinogen. Cardiol. 1997;88(5):468-73.
[13]Glaister M, Hauck H, Abraham CS, Merry KL, Beaver D, Woods B, et al. Familiarization, reliability, and comparability of a 40-m maximal shuttle run test. J Sports Sci Med. 2009;8(1):77-82.
[14]Wang JS, Jen CJ, Chen HI. Effects of exercise training and deconditioning on platelet function in men. Arterioscler Thromb Vasc Biol. 1995;15(10):1668-74.
[15]Mutanen M, Freese R. Fats, lipids and blood coagulation. Curr Opin Lipidol. 2001;12(1):25-9.
[16]Alzahrani SH, Ajjan RA. Coagulation and fibrinolysis in diabetes. Diab Vasc Dis Res. 2010;7(4):260-73.
[17]Smith JE, Garbutt G, Lopes P, Pedoe DT. Effects of prolonged strenuous exercise (marathon running) on biochemical and haematological markers used in the investigation of patients in the emergency department. Br J Sports Med. 2004;38(3):292-4.
[18]Duncan BB, Schmidt MI, Chambles LE, Folsom AR, Charpenter M, Heiss G. Fibrinogen, other putative markers of inflammation, and weight gain in middle-aged adults--the ARTC study: Atherosclerosis risk in communities. Obes Res. 2000;8(4):279-86.
[19]Kupchak BR, Volk BM, Kunces LJ, Kraemer WJ, Hoffman MD, Phinney SD, et al. Alterations in coagulatory and fibrinolytic systems following an ultra-marathon. Eur J Appl Physiol. 2013;113(11):2705-12.
[20]Parker BA, Augeri AL, Capizzi JA, Ballard KD, Kupchak BR, Volek JS, et al. Effect of marathon run and air travel on pre-and post-run soluble d-dimer, microparticle procoagulant activity, and p-selectin levels. Am J Cardiol. 2012;109(10):1521-5.
[21]Posthuma JJ, van der Meijden PE, ten Cate H, Spronk HM. Short-and Long-term exercise induced alterations in haemostasis: A review of the literature. Blood Rev. 2015;29(3):171-8.
[22]Heber S, Volf I. Effects of physical (in) activity on platelet function. Biomed Res Int. 2015;2015:1-11.
[23]Ahmadizad S, El-Sayed MS, MacLaren DP. Responses of platelet activation and function to a single bout of resistance exercise and recovery. Clin Hemorheol Microcirc. 2006;35(1-2):159-68.
[24]Ahmadizad S, El-Sayed MS. The effects of graded resistance exercise on platelet aggregation and activation. Med Sci Sports Exerc. 2003;35(6):1026-32.
[25]Soleimani M, Amini A, Ahmadi A, Atashak S, Mehdivand A, Kawsari E, et al. Effect of short-term supplementation of cocoa on platelet factors (Plt, MPV, PDW) of athlete male’s blood after an exhaustive aerobic exercise. J Kurdistan Uni Med Sci. 2013;18(4):18-27. [Persian]
[26]San Jose MCZ, Apaga NEP, Florento L, Gan RN. Effects of aerobic exercise and training on coagulation, platelet aggregation, and plasma lipids. Vasc Dis Prev. 2005;2(2):145-50.
[27]Menzel K, Hilberg T. Blood coagulation and fibrinolysis in healthy, untrained subjects: Effects of different exercise intensities controlled by individual anaerobic threshold. Eur J Appl Physiol. 2011;111(2):253-60.
[28]Hilberg T, Gläser D, Reckhart C, Prasa D, Stürzebecher J, Gabriel HH. Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold. Eur J Appl Physiol. 2003;90(5-6):639-42.
[29]Piccone G, Fazio F, Giudice E, Grasso F, Caola G. Exercise-induced change in clotting times and fibrinolytic activity during official 1600 and 2000 meters trot races in standard horses. Acta Vet Brno. 2005;74(4):509-14.