ARTICLE INFO

Article Type

Original Research

Authors

Sadeghi   M. (1 )
Abbassi Daloii   A. (*)
Ziaolhagh   S.J. (2 )






(*) Exercise Physiology Department, Sport Sciences Faculty, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
(1 ) Exercise Physiology Department, Physical Education Faculty, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
(2 ) Exercise Physiology Department, Sport Sciences Faculty, Shahrood Branch, Islamic Azad University, Shahrood, Iran

Correspondence

Address: Sport Sciences Faculty, Islamic Azad University, Ayatollah Amoli Branch, Old road Amol, Amol, Iran
Phone: +98 (11) 44150949
Fax: +98 (11) 44150949
abbasi.daloii@gmail.com

Article History

Received:   July  4, 2016
Accepted:   February 15, 2017
ePublished:   July 22, 2017

ABSTRACT

Aims Using anabolic androgenic steroids by athletes has significant side effects on sex hormones and the reproductive system. The aim of this study was to investigate the effect of 6 weeks of resistance exercise and Boldenone supplements on the expression of 5-alpha reductase and aromatase genes of the testis tissue in Wistar rats.
Materials & Methods In this experimental study, thirty 12-week old male Wistar rats with the average weight of 195.00±7.94 grams were divided randomly into 5 groups; control, sham, Boldenone supplements (2mg per each kilogram of body weight), resistance exercise and Boldenone exercise. Resistance exercise program was 5 sessions of climbing the ladder each week (3 sets of 5 repeats) for 6 weeks that was started by 50% of one maximum repetition and reached 100% at the end. The level of 5-alpha reductase and aromatase genes expression were measured after the anesthesia and the removal of the testes tissue in the samples. Data was analyzed by paired T, ANOVA and Tukey post hoc tests by using SPSS 22 software.
Findings The average weight of all groups’ mice were significantly increased in week 6 comparing to the first week (p=0.0001). There was significant increasing in 5-alpha-reductase expression in Boldenone and Boldenone exercise than the control group and also in the Boldenone exercise than resistance exercise group after the intervention. There was significant increasing in aromatase gene expression in resistance exercise and Boldenone exercise groups than the control group (p<0.05).
Conclusion Boldenone supplement along with 6 weeks of resistance exercise increases the levels of 5-alpha reductase and aromatase genes expression in testis tissue of Wistar rats.

Keywords: Resistance Training , Boldenone , 5-alpha Reductase , Aromatase, Testis ,

CITATION LINKS

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