@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(4):325-330
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(4):325-330
Hypoglycemic Interactive Effects of Ginger Eextract and Eendurance Training in Diabetic Rats
ARTICLE INFO
Article Type
Original ResearchAuthors
Hosseini S.A. (*)Nemati J. (1)
Ranjbar M. (2)
Edalatmanesh M.A. (3)
Zar A. (4)
(*) Sport Physiology Department, Human Science Faculty, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
(1) Physical Education Department, Educational Science & Psychology Faculty, Shiraz University, Shiraz, Iran
(2) Sport Physiology Department, Human Science Faculty, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
(3) Biology Department, Sciences Faculty, Shiraz Branch, Islamic Azad University, Shiraz, Iran
(4) Physical Education & Sport Science Department, Literature & Humane Science Faculty, Jahrom University, Jahrom, Iran
Correspondence
Address: Sport Physiology Department, Human Science Faculty, Marvdasht Branch, Islamic Azad University, Marvdasht, IranPhone: +98 (71) 43311172
Fax: +98 (71) 37323216
alihoseini_57@yahoo.com
Article History
Received: October 24, 2016Accepted: April 12, 2017
ePublished: September 28, 2017
ABSTRACT
Aims
Diabetes is a metabolic disorder that results in hyperglycemia due to
non-regulation of blood glucose. The aim of this study was to evaluate the
hypoglycemic interactive effects of Ginger extract and endurance training in
diabetic rats.
Materials & Methods In this experimental study, 40 streptozotocin-induced diabetic rats were randomly divided into four groups (control, endurance training, Ginger extract and endurance training with Ginger extract). The training groups ran 8 to 16 meters per minute for four weeks, five sessions per week, and each session for 30 minutes on treadmill. Ginger extract groups received daily 100 mg/kg Ginger extract intraperitoneal for four weeks. At the end, levels of fasting glucose, insulin and insulin resistance were measured. Data were analyzed by SPSS 21 software using dependent T-test, one way ANOVA and Tukey's post hoc test.
Findings Levels of fasting glucose, insulin and insulin resistance in endurance training group, Ginger extract group and endurance training with Ginger extract group were significantly lower than control group. Also, levels of fasting glucose, insulin and insulin resistance in endurance training with Ginger extract group were significantly lower than endurance training group and Ginger extract group (p<0.01).
Conclusion Endurance training with use of Ginger extract has hypoglycemic interactive effects on improving glucose indices in diabetic rats, leading to a decrease in levels of fasting glucose, insulin and insulin resistance in streptozotocin-induced diabetic rats.
Materials & Methods In this experimental study, 40 streptozotocin-induced diabetic rats were randomly divided into four groups (control, endurance training, Ginger extract and endurance training with Ginger extract). The training groups ran 8 to 16 meters per minute for four weeks, five sessions per week, and each session for 30 minutes on treadmill. Ginger extract groups received daily 100 mg/kg Ginger extract intraperitoneal for four weeks. At the end, levels of fasting glucose, insulin and insulin resistance were measured. Data were analyzed by SPSS 21 software using dependent T-test, one way ANOVA and Tukey's post hoc test.
Findings Levels of fasting glucose, insulin and insulin resistance in endurance training group, Ginger extract group and endurance training with Ginger extract group were significantly lower than control group. Also, levels of fasting glucose, insulin and insulin resistance in endurance training with Ginger extract group were significantly lower than endurance training group and Ginger extract group (p<0.01).
Conclusion Endurance training with use of Ginger extract has hypoglycemic interactive effects on improving glucose indices in diabetic rats, leading to a decrease in levels of fasting glucose, insulin and insulin resistance in streptozotocin-induced diabetic rats.
CITATION LINKS
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[6]Moghadasi M, Mohammadi Demyeh A, Khaje Landi A, Rostami A. Comparison of the effects of 8 weeks strength and endurance training on the plasma levels of visfatin in middle-aged men. J Exe Physiol. 2012;4(3):39-49. [Persian]
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[11]Saghir Ahmad J, Sohail A, Muhammad Q. Hypoglycemic effect of ginger (zingiber officinale) in alloxan induced diabetic rats (rattus norvagicus). Pakistan Veterinary J. 2011;31(2): 160-2.
[12]Dehghan F, Hajiaghaalipour F, Yusof A, Muniandy S, Hosseini SA, Heydari S, et al. saffron with resistance exercise improves diabetic parameters through the glut4/ampk pathway in-vitro and in-vivo. Sci Rep. 2016;6: 1-12.
[13]Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO. Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2009;297(1):E151-6.
[14]Mohebbi H, Khazaei MH, Esfahani M. The effect of aerobic exercise on blood glucose control, cardiorespiratory fitness and risk factors associated with cardiovascular disease, non-insulin dependent diabetes and extreme poor. Olympic. 2006;14(6):17-24. [Persian]
[15]Hosseini SA, Nikbakht H, Azarbayjani M.A. The effect of aqua extract of saffron with resistance training on glycemic indexes of streptozotosin induced diabetic rats. Armaghan Danesh. 2014;18(4):284-94. [Persian]
[16]Hossaini SA, Giti Z, Norizadeh R, Mohammadpur F, Noora M. The effects of eight weeks of aerobic training on vaspin, visfatin and insulin resistance, middle-aged women. J Res Sport Sci. 2012;2(6):55-67. [Persian]
[17]Meigs JB. Invited commentary: Insulin resistance syndrome? syndrome x? multiple metabolic syndrome? a syndrome at all? factor analysis reveals pattern in fabric of correlated metabolic risk factors. Am J Epidemiol. 2000;152(10):908-11.
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[19]Mohseni Mehran S, Norasfard M R, Abedinzade M, Khanaki K. Comparison the effects of lamium album and urticadioicaonserum level of glucose and lipid profile in male diabetic rats. J Guilan Univ Med Sci. 2015; 24(93):47-53. [Persian]
[20]Khalili Najaf Abadi M, Rahmati B. Analgesic effect of alcoholic Datura stramonium L. seed extract on stereptozotocine-induced diabetic male rats. J Med Plants. 2005;2(14):21-29. [Persian]
[21]Zar A, Hoseini SA, Ahmadi F, Rezaei M. Effects of Ginger with Swimming Training on Blood Fat Profiles in Adult Diabetic Rats with Streptozotocin. Iran J Nutr Food Sci Food Technol. 2016;11(2):65-74. [Persian]
[22]Myrbadalzadeh R, Shirdel Z. Effect of Antihyperglycemic and antihyperlipidemic effects of blueberry extract (cornus mas) on diabetic rats and comparison with glibenclamide. Iran J Diabetes Metab. 2010;9(4):335-43. [Persian]
[23]- Atashak S, Peeri M, Jafari A, Azarbayijani M. Effects of 10 week resistance training and ginger consumption on c-reactive protein and some cardiovascular risk factors in obese men. Physiol Pharmacol. 2010;14(3):318- 28. [Persian]
[24]Motallebi F, Shakerian S, Ranjbar R. Effect of 8 weeks aerobic interval training on glycosylated hemoglobin and insulin resistance index in diabetic mellitus type 2 women. Horizon Med Sci. 2016;22(2):137-43. [Persian]
[25]Hosseinian M, Banitalebi E, Amirhosseini SE. Effect of 12 weeks of intensive interval and combined training on apolipoprotein a and b, visfatin and insulin resistance in overweight middle-aged women with type 2 diabetes. Horizon Med Sci. 2016;22(3):237-45. [Persian]
[2]Falahaty J, Rezaee R, Astaneh S, Mousavi FM. The awareness of diabetic patients with different levels of retinopathy of eye complications associated with diabetes. J Arak Univ Med Sci. 2009;13(3):116-22. [Persian]
[3]Soori R, Hassani Ranjbar S, Wahhabi C, Shbkhyz F. The effect of aerobic exercise on serum RBP4 and insulin resistance index in type 2 diabetic patients. Iran J Diabetes Metab. 2011;10(4):388-97. [Persian]
[4]Yavari AS, Najafipour F, Ali Skrzadh A, Nyafr M, Surveillance M, Goodcharacter SA. Effect of aerobic exercise, resistance training or combined training on glycemic control and cardiovascular risk factors in patients with type 2 diabetes mellitu. J Tabriz Univ Med Sci. 2011;4:82-91. [Persian]
[5]Marcus RL, Smith S, Morrell G, Addison O, Dibble LE, Wahoff-Stice D, et al. Comparison of combined aerobic and high- force eccentric resistance exercise with aerobic exercise only for people with type 2 diabetes mellitus. Phys Ther. 2008;88(11):1345-54.
[6]Moghadasi M, Mohammadi Demyeh A, Khaje Landi A, Rostami A. Comparison of the effects of 8 weeks strength and endurance training on the plasma levels of visfatin in middle-aged men. J Exe Physiol. 2012;4(3):39-49. [Persian]
[7]Winnick JJ, Sherman WM, Habash DL, Stout MB, Failla ML, Belury MA, et al. Short-term aerobic exercise training in obese humans with type 2 diabetes mellitus improves whole-body insulin sensitivity through gains in peripheral, not hepatic insulin sensitivity. J Clin Endocrinol Metab. 2008;93(3):771-8.
[8]Roghani M, Baluchnejadmojarad P, Roghani-Dehkordi F. Antihyperglycemic and antihyperlipidemic effect of chronic administration of hesperetin in diabetic rats. JBUMS. 2010;12(4):21-6. [Persian]
[9]Talaei B, Mozaffari-Khosravi H, Jalali B, Mahammadi M, Najarzadeh A, Fallahzadeh H. The effect of ginger on blood glucose, lipid and lipoproteins in patients with type 2 diabetes: A double-blind randomized clinical controlled trial. JSSU. 2012;20(3):383-95. [Persian]
[10]Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol. 2005;97(2):227-30.
[11]Saghir Ahmad J, Sohail A, Muhammad Q. Hypoglycemic effect of ginger (zingiber officinale) in alloxan induced diabetic rats (rattus norvagicus). Pakistan Veterinary J. 2011;31(2): 160-2.
[12]Dehghan F, Hajiaghaalipour F, Yusof A, Muniandy S, Hosseini SA, Heydari S, et al. saffron with resistance exercise improves diabetic parameters through the glut4/ampk pathway in-vitro and in-vivo. Sci Rep. 2016;6: 1-12.
[13]Kirwan JP, Solomon TP, Wojta DM, Staten MA, Holloszy JO. Effects of 7 days of exercise training on insulin sensitivity and responsiveness in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab. 2009;297(1):E151-6.
[14]Mohebbi H, Khazaei MH, Esfahani M. The effect of aerobic exercise on blood glucose control, cardiorespiratory fitness and risk factors associated with cardiovascular disease, non-insulin dependent diabetes and extreme poor. Olympic. 2006;14(6):17-24. [Persian]
[15]Hosseini SA, Nikbakht H, Azarbayjani M.A. The effect of aqua extract of saffron with resistance training on glycemic indexes of streptozotosin induced diabetic rats. Armaghan Danesh. 2014;18(4):284-94. [Persian]
[16]Hossaini SA, Giti Z, Norizadeh R, Mohammadpur F, Noora M. The effects of eight weeks of aerobic training on vaspin, visfatin and insulin resistance, middle-aged women. J Res Sport Sci. 2012;2(6):55-67. [Persian]
[17]Meigs JB. Invited commentary: Insulin resistance syndrome? syndrome x? multiple metabolic syndrome? a syndrome at all? factor analysis reveals pattern in fabric of correlated metabolic risk factors. Am J Epidemiol. 2000;152(10):908-11.
[18]Hanley AJ, Williams K, Stern MP, Haffner, SM. Homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease: the san antonio heart study. Diabetes Care. 2002;25(7): 1177-84.
[19]Mohseni Mehran S, Norasfard M R, Abedinzade M, Khanaki K. Comparison the effects of lamium album and urticadioicaonserum level of glucose and lipid profile in male diabetic rats. J Guilan Univ Med Sci. 2015; 24(93):47-53. [Persian]
[20]Khalili Najaf Abadi M, Rahmati B. Analgesic effect of alcoholic Datura stramonium L. seed extract on stereptozotocine-induced diabetic male rats. J Med Plants. 2005;2(14):21-29. [Persian]
[21]Zar A, Hoseini SA, Ahmadi F, Rezaei M. Effects of Ginger with Swimming Training on Blood Fat Profiles in Adult Diabetic Rats with Streptozotocin. Iran J Nutr Food Sci Food Technol. 2016;11(2):65-74. [Persian]
[22]Myrbadalzadeh R, Shirdel Z. Effect of Antihyperglycemic and antihyperlipidemic effects of blueberry extract (cornus mas) on diabetic rats and comparison with glibenclamide. Iran J Diabetes Metab. 2010;9(4):335-43. [Persian]
[23]- Atashak S, Peeri M, Jafari A, Azarbayijani M. Effects of 10 week resistance training and ginger consumption on c-reactive protein and some cardiovascular risk factors in obese men. Physiol Pharmacol. 2010;14(3):318- 28. [Persian]
[24]Motallebi F, Shakerian S, Ranjbar R. Effect of 8 weeks aerobic interval training on glycosylated hemoglobin and insulin resistance index in diabetic mellitus type 2 women. Horizon Med Sci. 2016;22(2):137-43. [Persian]
[25]Hosseinian M, Banitalebi E, Amirhosseini SE. Effect of 12 weeks of intensive interval and combined training on apolipoprotein a and b, visfatin and insulin resistance in overweight middle-aged women with type 2 diabetes. Horizon Med Sci. 2016;22(3):237-45. [Persian]