ARTICLE INFO

Article Type

Original Research

Authors

Saremi   A.T. (*)
Tarazi   B. (1)
Ghanbari   F. (2)






(*) ‎“Sarem Fertility & Infertility Research Center (SAFIR)” and “Sarem Cell Research Center (SCRC)” ‎, Sarem Women’s Hospital, Tehran, Iran
(1) ‎Aban Hospital, Tehran, Iran
(2) Sarem Women’s Hospital, Tehran, Iran

Correspondence


Article History

Received:   February  4, 2017
Accepted:   May 14, 2017
ePublished:   June 15, 2018

ABSTRACT

Aims Polycystic ovary syndrome (PCOS) is one of the clinical conditions associated ‎with chronic anovulation and infertility.‎‏ ‏Non-surgical procedures, including ‎ovulation induction drugs or surgical procedures, are used to treat it. The ‎objective of this study was to investigate the efficacy of laparoscopic ovarian ‎electrocautery on infertile patients with PCOS and resistance to ovulation ‎induction treatment.‎
Materials & Methods This experimental study was conducted on 183 infertile female patients with ‎PCOS and resistance to drug treatment that referred to Sarem women’s hospital ‎‎(Tehran, Iran) during a five-year period. Sampling was done by sequential census. ‎For all patients, ovarian laparoscopy and electrocautery were carried out and all ‎of them were subjected to ovulation induction protocols. Ovarian response was ‎evaluated along with variables such as age, duration of infertility, menstrual ‎status, the levels of LH and FSH, hirsutism, and time interval between laparoscopy ‎and ovulation. Data were analyzed by Chi-square and independent t tests using ‎SPSS software‏.‏
Findings The ovulation rate was found as 81.4% among the patients, but only in 26% of ‎those patients pregnancy completed successfully. There was no significant ‎relationships between ovulation with the levels of LH, FSH and LH/FSH ratio ‎‎(p>0.05). The relationship between ovarian response and postoperative treatment ‎protocol was significant (p=0.0001), which indicated a substantial treatment ‎response for any ovulation induction with clomid‏.‏
Conclusion Laparoscopic ovarian electrocautery is an appropriate treatment for infertile ‎patients with PCOS and resistance to ovulation induction treatment. ‎


CITATION LINKS

[1]Hull M. Epidemiology of infertility and polycystic ovarian disease: Endocrinological and demographic studies. Gynecol Endocrinol. 1987;1(3):235-45.
[2]Isikoglu M, Berkkanoglu M, Cemal H, Ozgur K. Polycystic ovary syndrome: What is the role of obesity?. In: Allahabadia GN, Agrawal R, editors. Polycystic Ovary Syndrome. United Kingdom: Anshan; 2007. p.157-63.
[3]Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1935;29(2):181-91.
[4]Zareian Z, Zareian P. Laparoscopic treatment of polycystic ovaries with unipolar forceps cautery. Razi J Med Sci. 2003;10(34):223-8.
[5]Esmailzadeh S, Nazari T. Effect of laparoscopic electrocautery of ovaries on ovarian response and fertility in poor response PCOS patients. Sci J Kurd Univ Med Sci. 2007;12(1):60-5.
[6]Cohen J. Laparoscopic procedures for treatment of infertility related to polycystic ovarian syndrome. Hum Reprod Update. 1996;2(4):337-44.
[7]Alborzi S, Robati M, Parsanejad M. The effectiv eness of laparoscopic electrocautery in clomip hene citrate resistant patients with p olycystic ovary syndrome in relation to ovarian size. Med J Islam Repub Iran. 2001;15(3):143-7.
[8]Sheehan MT. Polycystic Ovarian syndrome: Diagnosis and management. Clin Med Res. 2004;2(1):13-27.
[9]Carmina E, Koyama T, Chang L, Stanczyk FZ, Lobo RA. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome?. Am J Obstet Gynecol. 1992;167(6):1807-12.
[10]Barbieri Rl, Makris A, Randall Rw, Daniels G, Kistner Rw, Ryan KJ. Insulin stimulates androgen accumulation in incubations of ovarian stroma obtained from women with hyperandrogenism. J Clin Endocrinol Metab. 1986;62(5):904-10.
[11]Dunaif A, Graf M. Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. J Clin Invest. 1989;83(1):23-9.
[12]Dunaif A. Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis. Endocr Rev. 1997;18(6):774-800.
[13]Daniell JF, Miller W. Polycystic ovaries treated by laparoscopic laser vaporization. Fertil Steril. 1989;51(2):232-6.
[14]Buvat J, Buvat-herbaut M, Marcolin G, Racadot A, Fourlinnie JC, Beuscart R, et al. A double blind controlled study of the hormonal and clinical effects of bromocriptine in the polycystic ovary syndrome. J Clin Endocrinol Metab. 1986;63(1):119-24.
[15]Aakvaag A, GjøNnæss H. Hormonal response to electrocautery of the ovary in patients with polycystic ovarian disease. Br J Obstet Gynaecol. 1985;92(12):1258-64.
[16]Farhi J, Soule S, Jacobs HS. Effect of laparoscopic ovarian electrocautery on ovarian response and outcome of treatment with gonadotropins in clomiphene citrate-resistant patients with polycystic ovary syndrome. Fertil Steril. 1995;64(5):930-5.
[17]Granberg S, Wikland M. A comparison between ultrasound and gynecologic examination for detection of enlarged ovaries in a group of women at risk for ovarian carcinoma. J Ultrasound Med. 1988;7(2):59-64.
[18]Campo S. Ovulatory cycles, pregnancy outcome and complications after surgical treatment of polycystic ovary syndrome. Obstet Gynecol Surv. 1998;53(5):297-308.
[19]Greenblatt E. 9 Surgical options in polycystic ovary syndrome patients who do not respond to medical ovulation induction. Baillière Clin Obstet Gynaecol. 1993;7(2):421-33.
[20]Felemban A, Tan SL, Tulandi T. Laparoscopic treatment of polycystic ovaries with insulated needle cautery: A reappraisal. Fertil Steril. 2000;73(2):266-9.
[21]Ferraretti AP, Gianaroli L, Magli MC, Iammarrone E, Feliciani E, Fortini D. Transvaginal ovarian drilling: A new surgical treatment for improving the clinical outcome of assisted reproductive technologies in patients with polycystic ovary syndrome. Fertil Steril. 2001;76(4):812-6.