@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(1):51-56
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(1):51-56
Comparison of the Effect of Echium amoenum with Buspirone on the Anxiety of Cruciate Maze in Adult Male Rats
ARTICLE INFO
Article Type
Original ResearchAuthors
Javid Z. (1)Hosseini S.E. (*)
(*) Biology Department, Science Faculty, Shiraz Branch, Islamic Azad University, Shiraz, Iran
(1) Psychology Department, Human Sciences Faculty, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Correspondence
Address: Science Faculty, Shiraz Branch, Islamic Azad University, Kilometer 5 of Sadra Road, Shiraz, IranPhone: +987143311148
Fax: +987143311172
ebrahim.hossini@yahoo.com
Article History
Received: July 5, 2015Accepted: November 14, 2015
ePublished: December 15, 2015
ABSTRACT
Aims
Chemical compouds of Echium amoenum extract is effective in the treatment of anxiety. The present study was conducted with the aim of comparing the effect of aqueous extract of Echium amoenum with Buspirone which is widely used in treatment of anxiety disorders.
Materials & Methods In this experimental study, 80 adult male rats were divided randomly into 2 parts of acute and chronic treatment each part with 5 groups (each 8 mice) including control (without treatment), sham (recieving strilled water as drug solvent) and 3 experimental groups which received Buspirone, Echium amoenum hydroalcoholic extract and Buspirone+Echium amoenum hydroalcoholic extract. All treatments were performed for 7 days in acute and for 14 days in chronic group. Cruciate-maze test was used to measure anxiety and the time and frequency of rats' presence in the open and closed levers of the maze were recorded. Data were analyzed in SPSS 18 software using one-sided ANOVA and Tukey's statistical tests.
Findings In acute groups, the means level of anxiety in Echium amoenum (p<0.001), Buspirone (p<0.0001) and Buspirone+Echium amoenum (p<0.0001) groups were reduced significantly compared to the control group, but the anti-anxiety effect of Echium amoenum was significantly less than Buspirone and Buspirone+Echium amoenum. In chronic groups, the means level of anxiety were reduced in all experimental groups compared to the control group (p<0.0001).
Conclusion Buspirone and Echium amoenum extract both cause the reduction of anxiety level and the effect of Echium amoenum increase by increasing the time of treatment period.
Materials & Methods In this experimental study, 80 adult male rats were divided randomly into 2 parts of acute and chronic treatment each part with 5 groups (each 8 mice) including control (without treatment), sham (recieving strilled water as drug solvent) and 3 experimental groups which received Buspirone, Echium amoenum hydroalcoholic extract and Buspirone+Echium amoenum hydroalcoholic extract. All treatments were performed for 7 days in acute and for 14 days in chronic group. Cruciate-maze test was used to measure anxiety and the time and frequency of rats' presence in the open and closed levers of the maze were recorded. Data were analyzed in SPSS 18 software using one-sided ANOVA and Tukey's statistical tests.
Findings In acute groups, the means level of anxiety in Echium amoenum (p<0.001), Buspirone (p<0.0001) and Buspirone+Echium amoenum (p<0.0001) groups were reduced significantly compared to the control group, but the anti-anxiety effect of Echium amoenum was significantly less than Buspirone and Buspirone+Echium amoenum. In chronic groups, the means level of anxiety were reduced in all experimental groups compared to the control group (p<0.0001).
Conclusion Buspirone and Echium amoenum extract both cause the reduction of anxiety level and the effect of Echium amoenum increase by increasing the time of treatment period.
CITATION LINKS
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[8]Abolhassani M. Antiviral activity of borage (Echium amoenum). Arch Med Sci. 2010;6(3):366-9.
[9]Salim S, Sarraj N, Taneja M, Saha K, Tejada-Simon MV, Chugh G. Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats. Behav Brain Res. 2010;208(2):545-52.
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[12]Ciriano MG, Garcia-Herreros C, Larequi E, Valencia I, Ansorena D, Astiasaran I. Use of natural antioxidants from lyophilized wa¬ter extracts of Borago officinalis in dry fermented sausages en¬riched in omega-3 PUFA. Meat Sci. 2009;83(2):271-7.
[13]Faryadyan P, Khosravi A, Faryadian S, Kashiri M, Valizadeh R. The aqueous extract of ziziphora persica cause positive mood on depressive rat. Biomed Pharmacol J. 2014;7(1):137-42.
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[15]Abed A, Vaseghi G, Jafari E, Fattahian E, Babhadiashar N, Abed M. Echium Amoenum Fisch et mey: A review on its pharmacological and medicinal properties. Asian J Med Pharm Res. 2014;4(4):21-3.
[16]Hosseini A, Shariatifar N. Effects of methanolic extract of Echium amoenum Fisch & Mey on seizure induced by picrotoxin in mice. Horizon Med Sci. 2004;10(2):20-5. [Persian]
[17] Rabbani M, Sajjadi SE, Khalili S. A lack of tolerance to the anxiolytic action of Echium amoenum. Res Pharm Sci. 2011;6(2):101-6.
[18]Abed A, Minaiyan M, Ghannadi A, Mahzouni P, Babavalian MR. Effect of Echium amoenum Fisch et mey a traditional Iranian herbal remedy in an experimental model of acute pancreatitis. ISRN Gastroenterol. 2012;2012:1-7.
[19]Mahmoudi M, Shahidi S, Golmohammadi H, Mohammadi S. The effect of Echium amoenum hydro-alcoholic extract on blood glucose level, lipid profile and lipoproteins in streptozotocin-induced diabetic male rats. J Zanjan Univ Med Sci. 2015;23(97):72-81. [Persian]
[20]Velosa JF, Riddle MA. Pharmacologic treatment of anxiety disorders in children and adolescents. Child Adolesc Psychiatr Clin N Am. 2008;9(1):119-33.
[21]Queiroz CM, Alcântara FB, Yagüe AM, Bibancos T, Frussa-Filho R. Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice. Braz J Med Biol Res. 2002;35(2):237-42.
[22]Czoty PW, Nader MA. Effects of oral and intravenous administration of buspirone on food–cocaine choice in socially housed male cynomolgus monkeys. Neuropsychopharmacology. 2015;40(5):1072-83.
[23]Mohajjel Nayebi A,Asadi M. Effect of buspirone on morphine withdrawal syndrome in mice. Pharm Sci. 2009;14(4):229-35. [Persian]
[24]Eslami Shahrbabaki M, Sabzevari L, Haghdoost A, Davari Ashtiani R. A randomized double blind crossover study on the effectiveness of buspirone and methylphenidate in treatment of attention deficit/hyperactivity disorder in children and adolescents. Iran J Psychiatry Clin Psychol. 2013;18(4):284-92.
[25]Komaki A, Rasouli B, Shahidi S. Anxiolytic effect of Borago officinalis (boraginaceae) extract in male rats. Avicenna J Neuro Psych Physio. 2015;2(1):e27189.
[26]Hosseini SE, Hamzavi S, Agh baba H. The effects of alcoholic extract of Red poppy (Papaver rhoeas) on anxiety induced by elevated plus maze and the plasma corticosterone levels in adult male Wistar rats. J Sabzevar Univ Med Sci. 2015;22(4):557-64. [Persian]
[27]Sayyah M, Sayyah M, Kamalinejad M. A preliminary randomized double blind clinical trial on the efficacy of aqueous extract of Echium amoenum in the treatment of mild to moderate major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(1):166-9.
[28]Wu CF, Liu YL, Song M, Liu W, Wang JH, Li X, et al. Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice. Pharmacol Biochem Behav. 2003;76(1):103-9.
[29]Akimova E, Lanzenberger R, Kasper S. The serotonin-1A receptor in anxiety disorders. Biol Psychiatry. 2009;66(7):627-35.
[30]Artigas F, Adell A, Celada P. Pindolol augmentation of antidepressant response. Curr Drug Targets. 2006;7(2):139-47.
[31]Lanzenberger RR, Mitterhauser M, Spindelegger C, Wadsak W, Klein N, Mien LK, et al. Reduced serotonin-1A receptor binding in social anxiety disorder. Biol Psychiatry. 2007;61(9):1081-9.
[32]Byers AL, Yaffe K, Covinsky KE, Friedman MB, Bruce ML. High occurrence of mood and anxiety disorders among older adults: The national comorbidity survey replication. Arch Gen Psychiatry. 2010;67(5):489-96.
[2]Drayer RA, Piraino B, Reynolds CF, Houck PR, Mazumdar S, Bernardini J, et al. Characteristics of depression in hemodialysis patients: Symptoms, quality of life and mortality Risk. Gen Hosp Psychiatry. 2006;28(4):306-12.
[3]Strine TW, Chapman DP, Kobau R, Balluz L, Mokdad AH. Depression, anxiety, and physical impairments and quality of life in the U.S. no institutionalized population. Psychiatr Serv. 2004;55(12):1408-13.
[4]Hosseini E, Tadayon Z. The effectiveness of drug therapy, relaxation and compound therapy on anxiety reduction, level of epinephrine and norepinephrine among patients with generalized anxiety disorder. Pars J Med Sci. 2013;10(4):61-8. [Persian]
[5]Muschalla B, Linden M, Olbrich D. The relationship between job-anxiety and trait-anxiety-a differential diagnostic investigation with the Job-Anxiety-Scale and the State-Trait-Anxiety-Inventory. J Anxiety Disord. 2010;24(3):366-71.
[6]Hatano VY, Torricelli AS, Giassi AC, Coslope LA, Viana MB. Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(-)-carvone in the elevated T-maze. Braz J Med Biol Res. 2012;45(3):238-43.
[7]Saiah Bargard M, Asadi M, Amini H, Saiah M, Akondzadeh Sh, Kamalianejad M. Efficacy of aqueous extract of Echium amoenum L. in the treatment of mild to moderate major depressive disorder: A randomized double blind clinical trial. J Med Plant. 2004;10(3):61-70. [Persian]
[8]Abolhassani M. Antiviral activity of borage (Echium amoenum). Arch Med Sci. 2010;6(3):366-9.
[9]Salim S, Sarraj N, Taneja M, Saha K, Tejada-Simon MV, Chugh G. Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats. Behav Brain Res. 2010;208(2):545-52.
[10]Blanco MM, Costa CA, Freire AO, Santos JJ, Costa M. Neurobe¬havioral effect of essential oil of Cymbopogon citratus in mice. Phytomedicine. 2009;16(2-3):265-70.
[11]Delorme P, Jay M, Ferry S. Phytochemical inventory of indigenous Boraginaceae: study of alkaloids and polyphenolic compounds (antho cyanic and flavonic compounds). Plantes Medicinales et Phytotherapie. 1977;11(1):5-11.
[12]Ciriano MG, Garcia-Herreros C, Larequi E, Valencia I, Ansorena D, Astiasaran I. Use of natural antioxidants from lyophilized wa¬ter extracts of Borago officinalis in dry fermented sausages en¬riched in omega-3 PUFA. Meat Sci. 2009;83(2):271-7.
[13]Faryadyan P, Khosravi A, Faryadian S, Kashiri M, Valizadeh R. The aqueous extract of ziziphora persica cause positive mood on depressive rat. Biomed Pharmacol J. 2014;7(1):137-42.
[14]Gholamzadeh S, Zare S, Ilkhanipoor M. Anxiolytic effect of Echium amoenum during different treatment courses. Res J Biol Sci. 2008;3(2):176-8.
[15]Abed A, Vaseghi G, Jafari E, Fattahian E, Babhadiashar N, Abed M. Echium Amoenum Fisch et mey: A review on its pharmacological and medicinal properties. Asian J Med Pharm Res. 2014;4(4):21-3.
[16]Hosseini A, Shariatifar N. Effects of methanolic extract of Echium amoenum Fisch & Mey on seizure induced by picrotoxin in mice. Horizon Med Sci. 2004;10(2):20-5. [Persian]
[17] Rabbani M, Sajjadi SE, Khalili S. A lack of tolerance to the anxiolytic action of Echium amoenum. Res Pharm Sci. 2011;6(2):101-6.
[18]Abed A, Minaiyan M, Ghannadi A, Mahzouni P, Babavalian MR. Effect of Echium amoenum Fisch et mey a traditional Iranian herbal remedy in an experimental model of acute pancreatitis. ISRN Gastroenterol. 2012;2012:1-7.
[19]Mahmoudi M, Shahidi S, Golmohammadi H, Mohammadi S. The effect of Echium amoenum hydro-alcoholic extract on blood glucose level, lipid profile and lipoproteins in streptozotocin-induced diabetic male rats. J Zanjan Univ Med Sci. 2015;23(97):72-81. [Persian]
[20]Velosa JF, Riddle MA. Pharmacologic treatment of anxiety disorders in children and adolescents. Child Adolesc Psychiatr Clin N Am. 2008;9(1):119-33.
[21]Queiroz CM, Alcântara FB, Yagüe AM, Bibancos T, Frussa-Filho R. Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice. Braz J Med Biol Res. 2002;35(2):237-42.
[22]Czoty PW, Nader MA. Effects of oral and intravenous administration of buspirone on food–cocaine choice in socially housed male cynomolgus monkeys. Neuropsychopharmacology. 2015;40(5):1072-83.
[23]Mohajjel Nayebi A,Asadi M. Effect of buspirone on morphine withdrawal syndrome in mice. Pharm Sci. 2009;14(4):229-35. [Persian]
[24]Eslami Shahrbabaki M, Sabzevari L, Haghdoost A, Davari Ashtiani R. A randomized double blind crossover study on the effectiveness of buspirone and methylphenidate in treatment of attention deficit/hyperactivity disorder in children and adolescents. Iran J Psychiatry Clin Psychol. 2013;18(4):284-92.
[25]Komaki A, Rasouli B, Shahidi S. Anxiolytic effect of Borago officinalis (boraginaceae) extract in male rats. Avicenna J Neuro Psych Physio. 2015;2(1):e27189.
[26]Hosseini SE, Hamzavi S, Agh baba H. The effects of alcoholic extract of Red poppy (Papaver rhoeas) on anxiety induced by elevated plus maze and the plasma corticosterone levels in adult male Wistar rats. J Sabzevar Univ Med Sci. 2015;22(4):557-64. [Persian]
[27]Sayyah M, Sayyah M, Kamalinejad M. A preliminary randomized double blind clinical trial on the efficacy of aqueous extract of Echium amoenum in the treatment of mild to moderate major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2006;30(1):166-9.
[28]Wu CF, Liu YL, Song M, Liu W, Wang JH, Li X, et al. Protective effects of pseudoginsenoside-F11 on methamphetamine-induced neurotoxicity in mice. Pharmacol Biochem Behav. 2003;76(1):103-9.
[29]Akimova E, Lanzenberger R, Kasper S. The serotonin-1A receptor in anxiety disorders. Biol Psychiatry. 2009;66(7):627-35.
[30]Artigas F, Adell A, Celada P. Pindolol augmentation of antidepressant response. Curr Drug Targets. 2006;7(2):139-47.
[31]Lanzenberger RR, Mitterhauser M, Spindelegger C, Wadsak W, Klein N, Mien LK, et al. Reduced serotonin-1A receptor binding in social anxiety disorder. Biol Psychiatry. 2007;61(9):1081-9.
[32]Byers AL, Yaffe K, Covinsky KE, Friedman MB, Bruce ML. High occurrence of mood and anxiety disorders among older adults: The national comorbidity survey replication. Arch Gen Psychiatry. 2010;67(5):489-96.