ARTICLE INFO

Article Type

Original Research

Authors

Ahmadi Moghadam   M. (* )
Shahraki   M.R. (1 )






(* ) Sistan and Baluchestan Branch, Jahad-e-Daneshgahi, Zahedan, Iran
(1 ) Physiology Department, Medicine Faculty, Zahedan University of Medical Sciences, Zahedan, Iran

Correspondence

Address: Deputy of Research, 3rd Floor, Local Studies &Specialty Services of Jahad-e-Daneshgahi of Sistan & Baloochestan Biulding, Across From Central Organization of the University, Janbazan Boulevard, Daneshgah Street, Zahedan, Iran. Postal Code: 98135-655
Phone: +985433413648
Fax: +985433413650
ahmadi_m1364@mihanmail.ir

Article History

Received:   September  3, 2014
Accepted:   January 15, 2015
ePublished:   February 19, 2015

ABSTRACT

Aims Ziziphora tenuior L. is used as an analgesic and to treat digestive diseases in Iranian traditional medicine. This study aimed to evaluate the analgesic effect of hydroalcoholic extract of Ziziphora tenuior L. on pain and compare it with Diclofenac in male rats.
Materials & Methods This Experimental study was done on 72 male rats. Animals were randomly divided into 9 group (n=8) including C (with no treatment), P (Placebo receiving water and alcohol), K400, K800, and K1600 (receiving the extract 400, 800, and 1600mg/ kg doses respectively), DK1600 (receiving 0.4mg/kg Diclophenac and 1600mg/kg dose of the extract), N (receiving Naloxan), and M (receiving Morphine). 15min after each oral administration, animals were injected with formalin and animal movements and behavior were recorded in two acute and chronic phases. Data were analyzed by SPSS 22 software using Tukey and One-way ANOVA tests.
Findings Pain score in PC group reduced significantly compared to C group (p≤0.05). Pain significantly decreased in K400, K800 and K1600 groups compared with control group (p≤0.05). Pretreatment with Naloxone significantly reduced analgesic effect of the extract compared with control group (p≤0.05).
Conclusion Ziziphora tenuior L. decreases pain that might be caused by compounds such as Limonene and Pulegone especially.

Keywords: Analgesics, Pain, Diclofenac, Pain Measurement,

CITATION LINKS

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