@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(4):345-351
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(4):345-351
Effect of Hydroalcoholic Extracts of Anethum graveolens L. with Swimming Training on Lipid Profile of Diabetic Rats
ARTICLE INFO
Article Type
Original ResearchAuthors
Askari M. (1)Hosseini S.A. (*)
(*) Exercise Physiology Department, Exercise Physiology Department, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
(1) Exercise Physiology Department, Exercise Physiology Department, Yasooj Branch, Islamic Azad University, Yasooj, Iran
Correspondence
Address: Marvdasht Branch, Islamic Azad University, Takhte Jamshid Boulevard, Marvdasht City, Fars Province. Postal Code: 73711- 13119Phone: +98 (71) 43112201
Fax: +98 (71) 43311172
alihoseini_57@yahoo.com
Article History
Received: March 18, 2016Accepted: August 15, 2016
ePublished: October 1, 2016
ABSTRACT
Aims
In traditional medicine, dill (Anethum graveolens) is known as the reducer of glucose, lipid and cholesterol. Physical exercises are also from the main methods of controlling and treating diabetes and hyperlipidemia. The aim of this study was to evaluate the effect of swimming exercises for 6 weeks, hydroalcoholic extracts of Anethum graveolens and their combination on lipid profile of diabetic rats.
Materials & Methods In this experimental research, 48 Sprague Dawley male rats were randomly chosen and were divided into 4 groups (swimming training, hydroalcoholic extracts of dill, swimming exercises with hydroalcoholic extracts of dill, control), one week after induction of diabetes. Interventions were 6 weeks (5 sessions per week for 30min per session) of swimming exercises and intraperitoneal daily usage of 100mg/kg hydroalcoholic extracts of dill. After that, blood sampling was done from all samples to analyze the lipid profiles. Data was analyzed by dependent T, one way ANOVA and Tukey post hoc tests.
Findings Using hydroalcoholic extracts of dill, swimming exercises and their combination for 6 weeks had significant effect on reduction of LDL, VLDL, TG and Cholesterol of diabetic rats (p=0.001). Swimming exercises plus extract usage had more decreasing effect on LDL (p=0.008) and cholesterol (p=0.01) than extract usage alone had. In addition, The combination treatment had more increasing effect on HDL than just extract (p=0.001) and just exercise (p=0.01) had.
Conclusion Although 6 weeks of swimming exercises and usage of hydroalcoholic extracts of dill improves the lipid profile of diabetic rats, their combination treatment method is more effective.
Materials & Methods In this experimental research, 48 Sprague Dawley male rats were randomly chosen and were divided into 4 groups (swimming training, hydroalcoholic extracts of dill, swimming exercises with hydroalcoholic extracts of dill, control), one week after induction of diabetes. Interventions were 6 weeks (5 sessions per week for 30min per session) of swimming exercises and intraperitoneal daily usage of 100mg/kg hydroalcoholic extracts of dill. After that, blood sampling was done from all samples to analyze the lipid profiles. Data was analyzed by dependent T, one way ANOVA and Tukey post hoc tests.
Findings Using hydroalcoholic extracts of dill, swimming exercises and their combination for 6 weeks had significant effect on reduction of LDL, VLDL, TG and Cholesterol of diabetic rats (p=0.001). Swimming exercises plus extract usage had more decreasing effect on LDL (p=0.008) and cholesterol (p=0.01) than extract usage alone had. In addition, The combination treatment had more increasing effect on HDL than just extract (p=0.001) and just exercise (p=0.01) had.
Conclusion Although 6 weeks of swimming exercises and usage of hydroalcoholic extracts of dill improves the lipid profile of diabetic rats, their combination treatment method is more effective.
CITATION LINKS
[1]Hosseini SA, Shojae T, Hosseini SA. The effects of cinnamon on glycemic indexes and insulin resistance in adult male diabetic rats with streptozotocin. Yafteh. 20015;16(4):70-8. [Persian]
[2]Shojae T, Hosseini SA, Hosseini SA. Review the effect of endurance training on glycemic indexes of streptozotosin induced diabetic rats. Jahesh. 2013;15(3):39-46. [Persian]
[3]Payahoo L, Ostadrahimi A, Mobasseri M, Khaje Bishka Y. Anethum graveolens L. supplementation has anti-inflammatory effect in type 2 diabetic patients. Indian J Tradiy Knowl. 2014;13(3):461-5.
[4]Mobasseri M, Payahoo L, Ostadrahimi A, Khaje Bishak Y, Jafarabadi MA, Mahluji S. Anethum graveolens supplementation improves insulin sensitivity and lipid abnormality in type 2 diabetic patients. Pharma Sci. 2014;20:40-5.
[5]Abbasi Oshaghi E, Khodadadi I, Saidijam M, Yadegarazari R, Shabab N, Tavilani H, et al. Lipid lowering effects of hydroalcoholic extract of anethum graveolens l. and dill tablet in high cholesterol fed hamsters. Cholesterol. 2015;2015:1- 7.
[6]Yazdanparast R, Alavi M. Antihyperlipidaemic and antihypercholesterolaemic effects of anethum graveolens leaves after the removal of furocoumarins. Cytobios. 2001;105(410):185-91.
[7]Bahramikia S, Yazdanparast R. Efficacy of different fractions of Anethum graveolens leaves on serum lipoproteins and serum and liver oxidative status in experimentally induced hypercholesterolaemic rat models. Am J Clin Med. 2009;37(4):12-5.
[8]Farkhaie F, Hosseini SA, Edalat Manesh MA. The effect of endurance training with niglla sativa extract on lipid profile of diabetic rats. Jahesh. 2013;14(2):11-8. [Persian]
[9]Hosseini SA, Nikbakht H, Azarbayjani MA. The effect of aqua extract of saffron with resistance training on glycemic indexes of streptozotosin induced diabetic rats. Armaghan-e-Danesh. 2013;18(4):284-94. [Persian]
[10]Salih Sahib A, Hashim Mohammed I, Al-Gareeb A. Effects of Anethum graveolens leave powder on lipid profile in hyperlipidemic patients. Spatula DD. 2012;2(3):153-8.
[11]Mansouri M, Nayebi N, Keshtkar A, Hasani-Ranjbar SH, Taheri E, Larijani B. The effect of 12 weeks anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trial. Daru. 2012;20(1):47-54.
[12]Yousofvand N, Soltany A. Effects of hydroalcoholic extract of dill (Anethum graveolens) on the serum levels of blood lipids (cholesterol, triglycerides, LDL and HDL) in male NMRI mice. J Pharm Chem Biol Sci. 2015;3(1):114-21.
[13]Rashid Lamir A, Gholamian S, Hashemi Javaheri A, Dastani M. The effect of 4 weeks aerobic training according with the usage of Anethum graveolens on blood sugar and lipoproteins profile of diabetic women. Ann Biol Res. 2012;3(9):4313-9. [Persian]
[14]Ahmadi Mahmoodabadi N. The effects of hydroalcoholic extracts of dill (Anethum graveolens L.) and artichoke (Cynara scolymus L.) against type 1 diabetes mellitus. Iran J Med Aromat Plants. 2008;24(3):333-41. [Persian]
[15]Piri M, Shahin MA, Oryan Sh. The effects of Anethum on plasma lipid and lipoprotein in normal and diabetic rats fed high fat diets. Shahrekord Univ Med Sci J. 2010;11(4):15-25. [Persian]
[16]Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, et al. Red wine polyphenolics increase ldl receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. J Nutr. 2003;133(3):700-6.
[17]Mishra N. Haematological and hypoglycemic potential Anethum Graveolens seeds extract in normal and diabetic Swiss albino mice. Vet World. 2013;6(8):502-7.
[18]Eatemady-Boroujeni A, Kargarfard M, Mojtahedi H, Rouzbehani R, Dastbarhagh H. Comparison of the effects of 8-weeks aerobic training and resistance training on lipid profile in patients with diabetes type 2. J Isfahan Med Sch. 2014;32(282):524-33. [Persian]
[19]Azimidokht SM, Mogharnasi M, Kargar Shorki MK, Zarezadeh Mehrizi A. The effect of 8 weeks interval training on insulin resistance and lipid profiles in type 2 diabetic men treated with metformin. J Sport Biosci. 2015;7(3):461-76. [Persian]
[20]Ghiasi R, Ghadiri Soufi F, Somi MH, Mohaddes S, Mirzaie Bavil F, Naderi R, et al. Swim training improves homa- ir in type 2 diabetes induced by high fat diet and low dose of streptozotocin in male rats. Adv Pharm Bull. 2015;5(3):379-84.
[21]Barzegari A, Amouzad Mahdirejei H. Effects of 8 weeks resistance training on plasma vaspin and lipid profile levels in adult men with type 2 diabetes. Caspian J Intern Med. 2014;5(2):103-8.
[22]Talebi Garakani E, Safarzade A. The effect of resistance training intensity on serum Apoa-i concentration in streptozotocin- induced diabetic rats. Iran J Endocrinol Metab. 2013;15(2):183-232. [Persian]
[23]Mokhtari F, Esfarjani F, Kargar Fard M. The effect of combined aerobic exercise and barly beta glucan on lipid profile and glucose blood of women with type 2 diabetes. Iran J Diabetes Metab. 2014;13(4):340-51. [Persian]
[24]Delevatti R, Marson E, Fernando Kruel L. Effect of aquatic exercise training on lipids proļ¬le and glycaemia: A systematic review. Rev Andal Med Deporte. 2015;8(4):163-70.
[25]Madani H, Ahmadi Mahmodabady N, Vahdati A. Effects of hydroalchoholic extract of Anethum graveolens (dill) on plasma glucose an lipid levels in diabetes induced rats. Iran J Diabetes Metab. 2005;5(2):109-16. [Persian]
[2]Shojae T, Hosseini SA, Hosseini SA. Review the effect of endurance training on glycemic indexes of streptozotosin induced diabetic rats. Jahesh. 2013;15(3):39-46. [Persian]
[3]Payahoo L, Ostadrahimi A, Mobasseri M, Khaje Bishka Y. Anethum graveolens L. supplementation has anti-inflammatory effect in type 2 diabetic patients. Indian J Tradiy Knowl. 2014;13(3):461-5.
[4]Mobasseri M, Payahoo L, Ostadrahimi A, Khaje Bishak Y, Jafarabadi MA, Mahluji S. Anethum graveolens supplementation improves insulin sensitivity and lipid abnormality in type 2 diabetic patients. Pharma Sci. 2014;20:40-5.
[5]Abbasi Oshaghi E, Khodadadi I, Saidijam M, Yadegarazari R, Shabab N, Tavilani H, et al. Lipid lowering effects of hydroalcoholic extract of anethum graveolens l. and dill tablet in high cholesterol fed hamsters. Cholesterol. 2015;2015:1- 7.
[6]Yazdanparast R, Alavi M. Antihyperlipidaemic and antihypercholesterolaemic effects of anethum graveolens leaves after the removal of furocoumarins. Cytobios. 2001;105(410):185-91.
[7]Bahramikia S, Yazdanparast R. Efficacy of different fractions of Anethum graveolens leaves on serum lipoproteins and serum and liver oxidative status in experimentally induced hypercholesterolaemic rat models. Am J Clin Med. 2009;37(4):12-5.
[8]Farkhaie F, Hosseini SA, Edalat Manesh MA. The effect of endurance training with niglla sativa extract on lipid profile of diabetic rats. Jahesh. 2013;14(2):11-8. [Persian]
[9]Hosseini SA, Nikbakht H, Azarbayjani MA. The effect of aqua extract of saffron with resistance training on glycemic indexes of streptozotosin induced diabetic rats. Armaghan-e-Danesh. 2013;18(4):284-94. [Persian]
[10]Salih Sahib A, Hashim Mohammed I, Al-Gareeb A. Effects of Anethum graveolens leave powder on lipid profile in hyperlipidemic patients. Spatula DD. 2012;2(3):153-8.
[11]Mansouri M, Nayebi N, Keshtkar A, Hasani-Ranjbar SH, Taheri E, Larijani B. The effect of 12 weeks anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; a randomized double blind controlled trial. Daru. 2012;20(1):47-54.
[12]Yousofvand N, Soltany A. Effects of hydroalcoholic extract of dill (Anethum graveolens) on the serum levels of blood lipids (cholesterol, triglycerides, LDL and HDL) in male NMRI mice. J Pharm Chem Biol Sci. 2015;3(1):114-21.
[13]Rashid Lamir A, Gholamian S, Hashemi Javaheri A, Dastani M. The effect of 4 weeks aerobic training according with the usage of Anethum graveolens on blood sugar and lipoproteins profile of diabetic women. Ann Biol Res. 2012;3(9):4313-9. [Persian]
[14]Ahmadi Mahmoodabadi N. The effects of hydroalcoholic extracts of dill (Anethum graveolens L.) and artichoke (Cynara scolymus L.) against type 1 diabetes mellitus. Iran J Med Aromat Plants. 2008;24(3):333-41. [Persian]
[15]Piri M, Shahin MA, Oryan Sh. The effects of Anethum on plasma lipid and lipoprotein in normal and diabetic rats fed high fat diets. Shahrekord Univ Med Sci J. 2010;11(4):15-25. [Persian]
[16]Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, et al. Red wine polyphenolics increase ldl receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. J Nutr. 2003;133(3):700-6.
[17]Mishra N. Haematological and hypoglycemic potential Anethum Graveolens seeds extract in normal and diabetic Swiss albino mice. Vet World. 2013;6(8):502-7.
[18]Eatemady-Boroujeni A, Kargarfard M, Mojtahedi H, Rouzbehani R, Dastbarhagh H. Comparison of the effects of 8-weeks aerobic training and resistance training on lipid profile in patients with diabetes type 2. J Isfahan Med Sch. 2014;32(282):524-33. [Persian]
[19]Azimidokht SM, Mogharnasi M, Kargar Shorki MK, Zarezadeh Mehrizi A. The effect of 8 weeks interval training on insulin resistance and lipid profiles in type 2 diabetic men treated with metformin. J Sport Biosci. 2015;7(3):461-76. [Persian]
[20]Ghiasi R, Ghadiri Soufi F, Somi MH, Mohaddes S, Mirzaie Bavil F, Naderi R, et al. Swim training improves homa- ir in type 2 diabetes induced by high fat diet and low dose of streptozotocin in male rats. Adv Pharm Bull. 2015;5(3):379-84.
[21]Barzegari A, Amouzad Mahdirejei H. Effects of 8 weeks resistance training on plasma vaspin and lipid profile levels in adult men with type 2 diabetes. Caspian J Intern Med. 2014;5(2):103-8.
[22]Talebi Garakani E, Safarzade A. The effect of resistance training intensity on serum Apoa-i concentration in streptozotocin- induced diabetic rats. Iran J Endocrinol Metab. 2013;15(2):183-232. [Persian]
[23]Mokhtari F, Esfarjani F, Kargar Fard M. The effect of combined aerobic exercise and barly beta glucan on lipid profile and glucose blood of women with type 2 diabetes. Iran J Diabetes Metab. 2014;13(4):340-51. [Persian]
[24]Delevatti R, Marson E, Fernando Kruel L. Effect of aquatic exercise training on lipids proļ¬le and glycaemia: A systematic review. Rev Andal Med Deporte. 2015;8(4):163-70.
[25]Madani H, Ahmadi Mahmodabady N, Vahdati A. Effects of hydroalchoholic extract of Anethum graveolens (dill) on plasma glucose an lipid levels in diabetes induced rats. Iran J Diabetes Metab. 2005;5(2):109-16. [Persian]