@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(3):171-176
ISSN: 2252-0805 The Horizon of Medical Sciences 2016;22(3):171-176
Comparison of Hemodynamic Variations, Bispectral Index and Myoclonus Score of Propofol Dosage in Anesthesia Induced Patients
ARTICLE INFO
Article Type
Original ResearchAuthors
Shabanian Gh. (1)Rafie M. (1)
Heidari-Soureshjani S. (2)
Shabanian A.R. (3)
Shabanian M.R. (*)
(*) Medicine Department, Medicine Faculty, Isfahan University of Medical Sciences, Isfahan, Iran
(1) Anesthesiology Department, Medicine Faculty, Shahrekord University of Medical Sciences, Shahrekord, Iran
(2) Deputy of Research & Technology, Shahrekord University of Medical Sciences, Shahrekord, Iran
(3) Dentistry Department, Medicine Faculty, Isfahan University of Medical Sciences, Isfahan, Iran
Correspondence
Address: Medicine Faculty, Isfahan University of Medical Sciences, Hezar Jarib Street, Isfahan, IranPhone:
Fax: +98212228600
shabanian.mohammadreza@gmail.com
Article History
Received: August 22, 2015Accepted: May 10, 2016
ePublished: June 30, 2016
ABSTRACT
Aims
Propofol is the most widely used intravenous anesthetic medication. It is necessary to assess the doses of the medication to determine proper anesthetic depth and to prevent its side-effects. The aim of this study was to compare 1 and 2.5mg/Kg doses of propofol in hemodynamic changes, myoclonus degree, and bi-spectral index (BIS) monitoring level in patients under anesthetic induction.
Materials & Methods In the two-blind random clinical trial study, 92 patients being candidate for surgery wit general anesthesia induction were studied in Shahr-e Kord Kashani Center in 2013. The subjects, selected via simple sampling method, were randomly divided into two groups. The first and the second groups were received 1 and 2.5mg/kg doses of propofol, respectively. Hemodynamic, myoclonus, and BIS indices were measured at four different times in the groups. Data was analyzed by SPSS 17 using independent T and Chi-square tests, as well as repeated ANOVA and Fisher’s test.
Findings There was no significant difference between the groups in the hemodynamic variables such as systolic and diastolic blood pressure, mean arterial blood pressure, pulse rate, and BIS (p>0.05). In addition, the change rates of the variables were the same. Nevertheless, there was a significant difference between the groups in the pulse change rate (p=0.032). There was no significant difference between the groups in myoclonus (p>0.05).
Conclusion The hemodynamic changes and the changes in myoclonus degree and BIS are the same in 1 and 2.5mg/kg doses of propofol in the patients undergoing anesthetic induction.
Materials & Methods In the two-blind random clinical trial study, 92 patients being candidate for surgery wit general anesthesia induction were studied in Shahr-e Kord Kashani Center in 2013. The subjects, selected via simple sampling method, were randomly divided into two groups. The first and the second groups were received 1 and 2.5mg/kg doses of propofol, respectively. Hemodynamic, myoclonus, and BIS indices were measured at four different times in the groups. Data was analyzed by SPSS 17 using independent T and Chi-square tests, as well as repeated ANOVA and Fisher’s test.
Findings There was no significant difference between the groups in the hemodynamic variables such as systolic and diastolic blood pressure, mean arterial blood pressure, pulse rate, and BIS (p>0.05). In addition, the change rates of the variables were the same. Nevertheless, there was a significant difference between the groups in the pulse change rate (p=0.032). There was no significant difference between the groups in myoclonus (p>0.05).
Conclusion The hemodynamic changes and the changes in myoclonus degree and BIS are the same in 1 and 2.5mg/kg doses of propofol in the patients undergoing anesthetic induction.
CITATION LINKS
[1]Karen T, Schlager GW, Bendix I, Sifringer M, Herrmann R, Pantazis C, et al. Effect of propofol in the immature rat brain on short- and long-term neurodevelopmental outcome. PLoS ONE. 2013;8(5):e64480.
[2]Anghelescu DL, Hamilton H, Faughnan LG, Johnson L-M, Baker JN. Pediatric palliative sedation therapy with propofol: Recommendations based on experience in children with terminal cancer. J Palliat Med. 2012;15(10):1082-90.
[3]Hong JY, Kang IS, Koong MK, Yoon HJ, Jee YS, Park JW, et al. Preoperative anxiety and propofol requirement in conscious sedation for ovum retrieval. J Korean Med Sci. 2003;18(6):863-8.
[4]Rahman NH, Hashim A. Is it safe to use propofol in the emergency department? A randomized controlled trial to compare propofol and midazolam. Int J Emerg Med. 2010;3(2):105-13.
[5]Horiuchi A, Nakayama Y, Kajiyama M, Kato N, Kamijima T, Ichise Y, et al. Safety and effectiveness of propofol sedation during and after outpatient colonoscopy. World J Gastroenterol. 2012;18(26):3420-5.
[6]VanNatta ME, Rex DK. Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy. Am J Gastroenterol 2006;101(10):2209-17.
[7]Alatise OI, Owojuyigbe AM, Yakubu MA, Agbakwuru AE, Faponle AF. Propofol versus traditional sedative methods for colonoscopy in a low-resource setting. Niger Postgrad Med J. 2015;22(3):151-7.
[8]Ingrande J, Brodsky JB, Lemmens HJ. Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects. Anesth Analg. 2011;113(1):57-62.
[9]Wang D, Chen C, Chen J, Xu Y, Wang L, Zhu Z, et al. The use of propofol as a sedative agent in gastrointestinal endoscopy: A meta-analysis. PLoS ONE. 2013;8(1):e53311.
[10]Naderi B, Haghighi M, Sedighinezhad A, Mohammadzade A, Mirzazade B. The comparison of different propofol dose for anesthesia induction based on BIS monitoring. J Guilan Univ Med Sci. 2008;17(65):88-93. [Persian]
[11]Shahbazi Sh, Haghighat A, Zand F. Bispecteral index and the amount of drugs needed in coronary artery bypass grafting under propofol: Remifentanil anesthesia method. J Iran Soc Anesthesiol Intensiv Care. 2005;4(52):5-14. [Persian]
[12]Muralidhar K, Banakal S, Murthy K, Garg R, Rani GR, Dinesh R. Bispectral index-guided anaesthesia for off-pump coronary artery bypass grafting. Ann Card Anaesth. 2008;11(2):105-10.
[13]Aprea F, Martin-Jurado O, Jenni S, Mosing M. Bispectral index analysis during cardiac arrest and cardiopulmonary resuscitation in a propofol-anesthetized calf. J Vet Emerg Crit Care (San Antonio). 2014;24(2):221-5.
[14]Jabalameli M, Hazegh N, Gholami S. The effects of hyperbaric or isobaric bupivacaine on bispectral index in spinal anesthesia for cesarean section. J Res Med Sci. 2012;17(2):176-81.
[15]Punjasawadwong Y, Phongchiewboon A, Bunchungmongkol N. Bispectral index for improving anaesthetic delivery and postoperative recovery. Cochrane Database Syst Rev. 2017;(4): CD003843.
[16]Klopman MA, Sebel PS. Cost-effectiveness of bispectral index monitoring. Curr Opin Anaesthesiol. 2011;24(2):177-81.
[17]Saber Moghadam M, Nikdelan AA, Alavinia SM. The incidence of abnormal movements and its associated factors during the induction of anesthesia with propofol . J North Khorasan Univ Med Sci. 2012;3(4):119-24. [Persian]
[18]Levy RJ. Clinical effects and lethal and forensic aspects of propofol. J Forensic Sci. 2011;56(0 1):S142-7.
[19]Symington L, Thakore S. A review of the use of propofol for procedural sedation in the emergency department. Emerg Med J. 2006;23(2):89-93.
[20]Giese JL, Stockham RJ, Stanley TH, Pace NL, Nelissen RH. Etomidate versus thiopental for induction of anesthesia. Anesth Analg. 1985;64(9):871-6.
[21]Seyed Hejazi M, Eydi M, Ghojazadeh M, Nejati A, Ghabili K, Golzari SEJ, et al. Propofol for laryngeal mask airway insertion in children: Effect of two different doses. Saudi J Anaesth. 2013;7(3):266-9.
[22]Zahoor A, Ahmed N. The effects of duration of injection on hemodynamics. Middle East J Anaesthesiol. 2010;20(6):846-50.
[23]Heck M, Kumle B, Boldt J, Lang J, Lehmann A, Saggau W. Electroencephalogram bispectral index predicts hemodynamic and arousal reactions during induction of anesthesia in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2000;14(6):693-7.
[2]Anghelescu DL, Hamilton H, Faughnan LG, Johnson L-M, Baker JN. Pediatric palliative sedation therapy with propofol: Recommendations based on experience in children with terminal cancer. J Palliat Med. 2012;15(10):1082-90.
[3]Hong JY, Kang IS, Koong MK, Yoon HJ, Jee YS, Park JW, et al. Preoperative anxiety and propofol requirement in conscious sedation for ovum retrieval. J Korean Med Sci. 2003;18(6):863-8.
[4]Rahman NH, Hashim A. Is it safe to use propofol in the emergency department? A randomized controlled trial to compare propofol and midazolam. Int J Emerg Med. 2010;3(2):105-13.
[5]Horiuchi A, Nakayama Y, Kajiyama M, Kato N, Kamijima T, Ichise Y, et al. Safety and effectiveness of propofol sedation during and after outpatient colonoscopy. World J Gastroenterol. 2012;18(26):3420-5.
[6]VanNatta ME, Rex DK. Propofol alone titrated to deep sedation versus propofol in combination with opioids and/or benzodiazepines and titrated to moderate sedation for colonoscopy. Am J Gastroenterol 2006;101(10):2209-17.
[7]Alatise OI, Owojuyigbe AM, Yakubu MA, Agbakwuru AE, Faponle AF. Propofol versus traditional sedative methods for colonoscopy in a low-resource setting. Niger Postgrad Med J. 2015;22(3):151-7.
[8]Ingrande J, Brodsky JB, Lemmens HJ. Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects. Anesth Analg. 2011;113(1):57-62.
[9]Wang D, Chen C, Chen J, Xu Y, Wang L, Zhu Z, et al. The use of propofol as a sedative agent in gastrointestinal endoscopy: A meta-analysis. PLoS ONE. 2013;8(1):e53311.
[10]Naderi B, Haghighi M, Sedighinezhad A, Mohammadzade A, Mirzazade B. The comparison of different propofol dose for anesthesia induction based on BIS monitoring. J Guilan Univ Med Sci. 2008;17(65):88-93. [Persian]
[11]Shahbazi Sh, Haghighat A, Zand F. Bispecteral index and the amount of drugs needed in coronary artery bypass grafting under propofol: Remifentanil anesthesia method. J Iran Soc Anesthesiol Intensiv Care. 2005;4(52):5-14. [Persian]
[12]Muralidhar K, Banakal S, Murthy K, Garg R, Rani GR, Dinesh R. Bispectral index-guided anaesthesia for off-pump coronary artery bypass grafting. Ann Card Anaesth. 2008;11(2):105-10.
[13]Aprea F, Martin-Jurado O, Jenni S, Mosing M. Bispectral index analysis during cardiac arrest and cardiopulmonary resuscitation in a propofol-anesthetized calf. J Vet Emerg Crit Care (San Antonio). 2014;24(2):221-5.
[14]Jabalameli M, Hazegh N, Gholami S. The effects of hyperbaric or isobaric bupivacaine on bispectral index in spinal anesthesia for cesarean section. J Res Med Sci. 2012;17(2):176-81.
[15]Punjasawadwong Y, Phongchiewboon A, Bunchungmongkol N. Bispectral index for improving anaesthetic delivery and postoperative recovery. Cochrane Database Syst Rev. 2017;(4): CD003843.
[16]Klopman MA, Sebel PS. Cost-effectiveness of bispectral index monitoring. Curr Opin Anaesthesiol. 2011;24(2):177-81.
[17]Saber Moghadam M, Nikdelan AA, Alavinia SM. The incidence of abnormal movements and its associated factors during the induction of anesthesia with propofol . J North Khorasan Univ Med Sci. 2012;3(4):119-24. [Persian]
[18]Levy RJ. Clinical effects and lethal and forensic aspects of propofol. J Forensic Sci. 2011;56(0 1):S142-7.
[19]Symington L, Thakore S. A review of the use of propofol for procedural sedation in the emergency department. Emerg Med J. 2006;23(2):89-93.
[20]Giese JL, Stockham RJ, Stanley TH, Pace NL, Nelissen RH. Etomidate versus thiopental for induction of anesthesia. Anesth Analg. 1985;64(9):871-6.
[21]Seyed Hejazi M, Eydi M, Ghojazadeh M, Nejati A, Ghabili K, Golzari SEJ, et al. Propofol for laryngeal mask airway insertion in children: Effect of two different doses. Saudi J Anaesth. 2013;7(3):266-9.
[22]Zahoor A, Ahmed N. The effects of duration of injection on hemodynamics. Middle East J Anaesthesiol. 2010;20(6):846-50.
[23]Heck M, Kumle B, Boldt J, Lang J, Lehmann A, Saggau W. Electroencephalogram bispectral index predicts hemodynamic and arousal reactions during induction of anesthesia in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2000;14(6):693-7.