@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2018;24(3):239-245
ISSN: 2252-0805 The Horizon of Medical Sciences 2018;24(3):239-245
The Incidence Rate of Vasovagal Reactions and Its Effective Factors Among Blood Donors in Mashhad Blood Transfusion Centers
ARTICLE INFO
Article Type
Original ResearchAuthors
Abbasnezhad A (1)Niazmand S (*)
Derakhshan M (2)
Shakeri MT (3)
Meshkini A (4)
Bayati M (4)
(*) Department of Physiology, Medicine Faculty, Mashhad University of Medical Sciences, Mashhad, Iran
(1) Department of Physiology, Medicine Faculty, Gonabad University of Medical Sciences, Gonabad , Iran
(2) Department of Microbiology, Medicine Faculty, Mashhad University of Medical Sciences, Mashhad , Iran
(3) Department of Epidemiology and Biostatistics, Health Faculty, Mashhad University of Medical Sciences, Mashhad, Iran
(4) Department of Anesthesiology, Health Faculty, Birjand University of Medical Sciences, Birjand, Iran
Correspondence
Address: Department of Physiology, Medicine Faculty, Mashhad University of Medical Sciences, Mashhad, IranPhone: +98 (51) 38002225
Fax: +98 (51) 38828564
niazmands@mums.ac.ir
Article History
Received: March 3, 2018Accepted: May 23, 2018
ePublished: July 23, 2018
ABSTRACT
Aims
Vasovagal reaction is one of the most common complications of blood
donation, this study was conducted to determine the prevalence of vasovagal
reactions and its effective factors among blood donors in Mashhad blood
transfusion centers.
Materials & Methods This case-control study was performed on 657 blood donors in Mashhad's four blood transfusion centers during 6 months. The donors who had vasovagal reactions were in the case group (218 cases), and 439 donors who did not respond to vasovagal were in the control group. The age, BMI, blood pressure, pulse rate, hematocrit and vasovagal response variables were studied. Data were analyzed by SPSS 11.5 using Chi-square and Mann-Whitney tests.
Findings The incidence of vasovagal reactions in the six months was 2.16%. The mean age in the case group was significantly lower than the control group (p<0.001). Vasovagal reactions were significantly higher in women and in first-time donors, as well as in those with anxiety and in subjects with lower BMI (p<0.001). The mean reduction in arterial pressure after blood donation was significantly higher in the case group than in the control group (p<0.001).
Conclusion The incidence of vasovagal reactions is dependent on several factors, including age, sex, BMI, and blood pressure, and with more care from high-risk donors, it can be approximately prevented from vasovagal reaction and increased the possibility of returning to blood donation.
Materials & Methods This case-control study was performed on 657 blood donors in Mashhad's four blood transfusion centers during 6 months. The donors who had vasovagal reactions were in the case group (218 cases), and 439 donors who did not respond to vasovagal were in the control group. The age, BMI, blood pressure, pulse rate, hematocrit and vasovagal response variables were studied. Data were analyzed by SPSS 11.5 using Chi-square and Mann-Whitney tests.
Findings The incidence of vasovagal reactions in the six months was 2.16%. The mean age in the case group was significantly lower than the control group (p<0.001). Vasovagal reactions were significantly higher in women and in first-time donors, as well as in those with anxiety and in subjects with lower BMI (p<0.001). The mean reduction in arterial pressure after blood donation was significantly higher in the case group than in the control group (p<0.001).
Conclusion The incidence of vasovagal reactions is dependent on several factors, including age, sex, BMI, and blood pressure, and with more care from high-risk donors, it can be approximately prevented from vasovagal reaction and increased the possibility of returning to blood donation.
CITATION LINKS
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[2]Assarian Z, Abed Haghighi B, Javadi I, Fotouhi A, Seighali F, Akbari N. Risk factors for vasovagal reactions during blood donation. Sci J Iran Blood Transfus Organ. 2011;7(4):221-6. [Persian]
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[5]Newman BH, Pichettle S, Pichette D, Dzaka E. Adverse effects in blood donors after whole-blood donation: A study of 1000 blood donors interviewed 3 weeks after whole blood donation. Transfusion. 2003;43(5):598-603.
[6]Zervou EK, Ziciadis K, Karabini F, Xanthi E, Chrisostomou E, Tzolou A. Vasovagal reactions in blood donors during or immediately after blood donation. Transfus Med. 2005;15(5):389-94.
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[9]Wiltbank TB, Giordano GF, Kamel H, Tomasulo P, Custer B. Faint and prefaint reactions in whole-blood donors: An analysis of predonation measurements and their predictive value. Transfusion. 2008;48(9):1799-808.
[10]Newman BH. Vasovagal reaction rates and body weight: Findings in high-and low-risk populations. Transfusion. 2003;43(8):1084-8.
[11]Ditto B, France CR. Vasovagal symptoms mediate the relationship between predonation anxiety and subsequent blood donation in female volunteers. Transfusion. 2006;46(6):1006-10.
[12]Nakajima K. Donor complications and donor care. ISBT Sci Ser. 2009;4(n2):411-7.
[13]Wiersum-Osselton JC, Marijt-van der Kreek T, de Kort WLAM. Donor vigilance: Progress and challenges. ISBT Sci Ser. 2012;7(1):251-5.
[14]Tomasulo P, Kamel H, Bravo M, James RC, Custer B. Interventions to reduce the vasovagal reaction rate in young whole blood donors. Transfusion. 2011;51(7):1511-21.
[15]Newman BH, Newman DT, Ahmad R, Roth AJ. The effect of whole-blood donor adverse events on blood donor return rates. Transfusion. 2006;46(8):1374-9.
[16]Hoogerwerf MD, van Dongen A, Middelburg RA, Merz EM, de Kort WLAM, Frings-Dresen MHW, et al. Negative experiences and pre-donation blood pressure: The role of attitude and anxiety. Transfus Med. 2017;27(2):105-13.
[17]Viar MA, Etzel EN, Ciesielski BG, Olatunji BO. Disgust, anxiety, and vasovagal syncope sensations: A comparison of injection-fearful and nonfearful blood donors. J Anxiety Disord. 2010;24(8):941-5.
[18]Javad Zadeh Shahshahani H, Yavari MT. Adverse effects in blood donors after whole blood donation. Sci J Iran Blood Transfus Organ. 2007;4(2):87-93. [Persian]
[19]Newman BH. Donor reactions and injuries from whole blood donation. Transfus Med Rev. 1997;11(1):64-75.
[20]Tondon R, Pandey P, Chaudhary R. Vasovagal reactions in 'at risk' donors: A univariate analysis of effect of age and weight on the grade of donor reactions. Transfus Apher Sci. 2008;39(2):95-9.
[21]Eder AF, Hillyer CD, Dy BA, Notari EP, Benjamin RJ. Adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds. JAMA. 2008;299(19):2279-86.
[22]Kapoor W, Snustad D, Peterson J, Wieand HS, Cha R, Karpf M. Syncope in the elderly. Am J Med. 1986;80(3):419-28.
[23]Imholz BP, Damdrink JH, Karemaker JM, Wieling W. Orthostatic circulatory control in the elderly evaluated by non-invasive continuous blood pressure measurement. Clin Sci (Lond). 1990;79(1):73-9.
[24]Newman BH. Vasovagal reactions in high school students: Findings relative to race, risk factor synergism, female sex, and non-high school participants.Transfusion. 2002;42(12):1557-60.
[25]Van Lieshout JJ, Wieling W, Karemaker JM, Eckberg DL. The vasovagal response. Clin Sci (Lond). 1991;81(5):575-86.
[26]Steptoe A, Swada Y. Assessment of baroreceptor reflex function during mental stress and relaxation. Psychophysiology. 1989;26(2):140-7.
[27]Vögele C, Steptoe A. Anger inhibition and family history as modulators of cardiovascular responses to mental stress in adolescent boys. J Psychosom Res. 1993;37(5):503-14.
[28]France C. Baroreflex sensivity during noxious stimulation in vasovagal reactors to blood donation. Int J Psychophysiol. 1995;19(1):13-22.
[29]Meade MA, France CR, Peterson LM. Predicting vasovagal reactions in volunteer blood donors. J Psychosom Res. 1996;40(5):495-501.
[30]Salins PC, Kuriakose M, Sharma SM, Tauro DP. Hypoglycemia as a possible factor in the induction of vasovagal syncope. Oral Surg Oral Med Oral Pathol. 1992;74(5):544-9.
[31]Ruiz GA, Calvar C, Hermes R, Rivadeneira D, Bengolea V, Chirife R, et al. Insulin sensitivity in young women with vasovagal syncope. Am Heart J. 2003;145(5):834-40.
[32]Yizuo D, Cheng W, Xiaohong X, Zuoxiang L, Ping L, Xiaoyan L, et al. Relationship of vasovagal syncope with height,weight and body mass index. Chinese J Crit Care Med. 2008;(2):97-9. [chinese]
[33]Rohra DK, Juriasinghani V, Rai K, Azam SI. Prevalence of immediate vasovagal reaction in blood donors visiting two blood banks of Karachi. Transfus Med. 2010;20(3):129-33.
[2]Assarian Z, Abed Haghighi B, Javadi I, Fotouhi A, Seighali F, Akbari N. Risk factors for vasovagal reactions during blood donation. Sci J Iran Blood Transfus Organ. 2011;7(4):221-6. [Persian]
[3]Trouern-Trend JJ, Cable RG, Badon SJ, Newman BH, Popovsky MA. A case-controlled multicenter study of vasovagal reactions in blood donors: Influence of sex, age, donation status, weight, blood pressure, and pulse. Transfusion. 1999;39(3):316-20.
[4]Newman BH. Blood donor complications after whole-blood donation. Curr Opin Hematol. 2004;11(5):339-45.
[5]Newman BH, Pichettle S, Pichette D, Dzaka E. Adverse effects in blood donors after whole-blood donation: A study of 1000 blood donors interviewed 3 weeks after whole blood donation. Transfusion. 2003;43(5):598-603.
[6]Zervou EK, Ziciadis K, Karabini F, Xanthi E, Chrisostomou E, Tzolou A. Vasovagal reactions in blood donors during or immediately after blood donation. Transfus Med. 2005;15(5):389-94.
[7]Newman BH, Satz SL, Janowicz NM, Siegfried BA. Donor reactions in high-school donors: The effects of sex, weight, and collection volume. Transfusion. 2006;46(2):284-8.
[8]Newman BH, Roth AJ. Estimating the probability of a blood donation adverse event based on 1000 interviewed whole-blood donors. Transfusion. 2005;45(11):1715-21.
[9]Wiltbank TB, Giordano GF, Kamel H, Tomasulo P, Custer B. Faint and prefaint reactions in whole-blood donors: An analysis of predonation measurements and their predictive value. Transfusion. 2008;48(9):1799-808.
[10]Newman BH. Vasovagal reaction rates and body weight: Findings in high-and low-risk populations. Transfusion. 2003;43(8):1084-8.
[11]Ditto B, France CR. Vasovagal symptoms mediate the relationship between predonation anxiety and subsequent blood donation in female volunteers. Transfusion. 2006;46(6):1006-10.
[12]Nakajima K. Donor complications and donor care. ISBT Sci Ser. 2009;4(n2):411-7.
[13]Wiersum-Osselton JC, Marijt-van der Kreek T, de Kort WLAM. Donor vigilance: Progress and challenges. ISBT Sci Ser. 2012;7(1):251-5.
[14]Tomasulo P, Kamel H, Bravo M, James RC, Custer B. Interventions to reduce the vasovagal reaction rate in young whole blood donors. Transfusion. 2011;51(7):1511-21.
[15]Newman BH, Newman DT, Ahmad R, Roth AJ. The effect of whole-blood donor adverse events on blood donor return rates. Transfusion. 2006;46(8):1374-9.
[16]Hoogerwerf MD, van Dongen A, Middelburg RA, Merz EM, de Kort WLAM, Frings-Dresen MHW, et al. Negative experiences and pre-donation blood pressure: The role of attitude and anxiety. Transfus Med. 2017;27(2):105-13.
[17]Viar MA, Etzel EN, Ciesielski BG, Olatunji BO. Disgust, anxiety, and vasovagal syncope sensations: A comparison of injection-fearful and nonfearful blood donors. J Anxiety Disord. 2010;24(8):941-5.
[18]Javad Zadeh Shahshahani H, Yavari MT. Adverse effects in blood donors after whole blood donation. Sci J Iran Blood Transfus Organ. 2007;4(2):87-93. [Persian]
[19]Newman BH. Donor reactions and injuries from whole blood donation. Transfus Med Rev. 1997;11(1):64-75.
[20]Tondon R, Pandey P, Chaudhary R. Vasovagal reactions in 'at risk' donors: A univariate analysis of effect of age and weight on the grade of donor reactions. Transfus Apher Sci. 2008;39(2):95-9.
[21]Eder AF, Hillyer CD, Dy BA, Notari EP, Benjamin RJ. Adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds. JAMA. 2008;299(19):2279-86.
[22]Kapoor W, Snustad D, Peterson J, Wieand HS, Cha R, Karpf M. Syncope in the elderly. Am J Med. 1986;80(3):419-28.
[23]Imholz BP, Damdrink JH, Karemaker JM, Wieling W. Orthostatic circulatory control in the elderly evaluated by non-invasive continuous blood pressure measurement. Clin Sci (Lond). 1990;79(1):73-9.
[24]Newman BH. Vasovagal reactions in high school students: Findings relative to race, risk factor synergism, female sex, and non-high school participants.Transfusion. 2002;42(12):1557-60.
[25]Van Lieshout JJ, Wieling W, Karemaker JM, Eckberg DL. The vasovagal response. Clin Sci (Lond). 1991;81(5):575-86.
[26]Steptoe A, Swada Y. Assessment of baroreceptor reflex function during mental stress and relaxation. Psychophysiology. 1989;26(2):140-7.
[27]Vögele C, Steptoe A. Anger inhibition and family history as modulators of cardiovascular responses to mental stress in adolescent boys. J Psychosom Res. 1993;37(5):503-14.
[28]France C. Baroreflex sensivity during noxious stimulation in vasovagal reactors to blood donation. Int J Psychophysiol. 1995;19(1):13-22.
[29]Meade MA, France CR, Peterson LM. Predicting vasovagal reactions in volunteer blood donors. J Psychosom Res. 1996;40(5):495-501.
[30]Salins PC, Kuriakose M, Sharma SM, Tauro DP. Hypoglycemia as a possible factor in the induction of vasovagal syncope. Oral Surg Oral Med Oral Pathol. 1992;74(5):544-9.
[31]Ruiz GA, Calvar C, Hermes R, Rivadeneira D, Bengolea V, Chirife R, et al. Insulin sensitivity in young women with vasovagal syncope. Am Heart J. 2003;145(5):834-40.
[32]Yizuo D, Cheng W, Xiaohong X, Zuoxiang L, Ping L, Xiaoyan L, et al. Relationship of vasovagal syncope with height,weight and body mass index. Chinese J Crit Care Med. 2008;(2):97-9. [chinese]
[33]Rohra DK, Juriasinghani V, Rai K, Azam SI. Prevalence of immediate vasovagal reaction in blood donors visiting two blood banks of Karachi. Transfus Med. 2010;20(3):129-33.