ARTICLE INFO

Article Type

Original Research

Authors

Sadegh   S. (* )
Golestany   A. (1 )






(* ) Sport Physiology Department, Physical Education & Sport Sciences Faculty, University of Bojnourd, Bojnourd, Iran
(1 ) Sport Physiology Department, Physical Education & Sport Sciences Faculty, University of Bojnourd , Bojnourd, Iran

Correspondence

Address: Physical Education & Sport Sciences Faculty, University of Bojnourd, Km 4 Esfarayen Road, Bojnourd, Iran
Phone: +98 (58) 32201000
Fax: +98 (58) 32201000
sadegh.saba1989@gmail.com

Article History

Received:  July  26, 2016
Accepted:  February 18, 2017
ePublished:  July 22, 2017

BRIEF TEXT


Multiple Sclerosis (MS) is a progressive autoimmune disease in the central nervous system that affects the brain and spinal cord and is characterized by degradation of the myelin of the neural cells and the formation of a scar tissue, causing impaired conduction of nervous and electrical currents. This disease is rising in the world and it is referred to as the disease of the century [1].

… [2-14]. Regarding the effect of exercise and proper diet on controlling cardiovascular risk factors, metabolic disorders, increasing prevalence of glucose intolerance, diabetics and lipid disorders, and about the positive effects of regular exercise programs on improving and regulating endocrine status, there are contradictory results [15, 16]. … [17-21].

The purpose of this study was to investigate the effect of 10 week aerobic exercise in water on levels of chemerin, insulin and serum insulin resistance in women with MS.

This is a quasi-experimental study with pretest and posttest design with control group.

This study was conducted in 2016 on MS patients with MS.

29 MS female patients were selected through targeted and convenience sampling.

The samples were divided into two experimental (n=15) and control (n=14) groups. Length, height, hip circumference, weight and body fat were measured. After the cardiopulmonary examination, blood pressure measurement, and electrocardiogram recording by a specialist physician, the subjects obtained permission to enter the design. Blood samples were collected 48 hours before the beginning of the exercise and 48 hours after the training session. The amount of chemerin was determined by ELISA and using the human kit (Casa biobiotic, Japan). The insulin resistance index (HOMA-IR) was also obtained using the following equation: Fasting insulin (micro unit per milliliter) x fasting glucose (microunit per milliliter)/22.5 The exercise protocol included 10 weeks of aerobic exercise, which was performed every week for 3 sessions and each session for 10 minutes. The exercise program included warm-up for 10 minutes, aerobic exercise for 45 to 60 minutes with an intensity equal to 60 to 75% of the maximum heart rate. The training session time gradually increased from 45 minutes to 60 minutes at the end of the course. The control group had no activity during the study period and was inactive (as before the study, had a passive mode of life). At the end of the design (after 10 weeks), similar to the pretest condition, all measurements were again performed and the data was collected. Statistical analysis: At the end, the collected data were analyzed using SPSS 20 software. After ensuring the distribution of data was normal by Kolmogorov-smirnov test and homogeneity of variances by levene test, two-way ANOVA was used to compare the intergroup changes and dependent t-test was used to examine the changes within the groups.

The characteristics of the experimental and control groups are shown in table 1. 10 weeks of training program in water resulted in a significant decrease in mean chemerin level (p=0.01), fasting glucose (p=0.03), insulin (p=0.04), and insulin resistance (p=0.01) in women with MS. However, there was no significant change in mean body weight and body mass index. Also, in the between group comparison in the variables of weight (p=0.03), body mass index (p=0.02), insulin level (p=0.01) and insulin resistance (p=0.0001), there was a significant difference between the control and experimental groups. However, there was no significant difference between the two groups in the level of chemerin and fasting glucose level (p>0.05; Table 2).

… [24-27]. The results of this study showed that 10-week aerobic training in MA patients resulted in significant decrease in fasting glucose, insulin and insulin resistance levels that this finding was consistent with the results of Bashiri et al. [28] and Garcia et al. [29]. However it does not conform to the findings of Faramarzi et al. [30]. … [31-34].

Regarding the results of this study about the effect of physical exercises on the improvement of cardiovascular biomarkers and the further support of related researches in this domain, the physical activity can be suggested to female patients with MS as an effective strategy along with other available strategies (such as education, appropriate nutrition, and hormone therapy).

This study was confronted with many limitations including a variety of diets, various adaptation responses to physical activity, few number of subjects due to the exclusion of some of them from participating in this study and individual differences.

10 weeks of aerobic exercise in water leads to lower level of chemerin, insulin and serum insulin resistance in women with MS.

Thanks and gratitude to the participants of the study who helped us with this research.

Non-declared

This research is approved by the Ethics Committee of the University of Bojnourd with the code 121235.

This article is from the master's degree dissertation of Ms. Saba Sadegh.

TABLES and CHARTS

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