@2024 Afarand., IRAN

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ISSN: 2252-0805    The Horizon of Medical Sciences 2015;21(2):129-134

Background
… [1-13] Herbal medicine is effective in treatment of different types of headache [14]. … [15] Coriandrum sativism L fruit has been reported as effective in the treatment of headache [16]. Analgesic, anti-inflammatory and sedative effect of coriander has been investigated compared to other medications such as morphine and aspirin and confirmed in many animal and human studies. Substances such as linalool in coriander cause anti-inflammatory and analgesic effects.
Previous Studies
Coriander reduces nitric acid production and increases noradrenaline and serotonin production, leading to pain decrease [17-22]. So far, no study has been done on the effect of the fruit of this plant on migraine headaches.
Aim(s)
This study aimed to investigate the effect of Coriander fruit on migraine attack severity and duration reduction.
Research type
This is a randomized controlled clinical triple blind trial study.
Research society, place and time
All patients aged 18 to 45years who had referred to neurological clinic of Tajrish Shohada Hospital in Tehran (Iran) in 2013 due to the headache complaint, visited by a neurologist physician, were studied in case of migraine diagnosis.
Sampling method and number
After determining the sample size using sample size determination in longitudinal data formula [23], 66 patients were studied. … [24, 25]
Used devices&materials
Using 4-block method, 66 patients were divided into two groups including intervention and control groups. Subjects in intervention group received common medications as well the selected medication of coriander and control group received a conventional medication along with placebo. 15ml consumption of coriander syrup or placebo, three times a day for a month, plus 500mg daily use of sodium valproate and 10mg nortriptyline as common medication were the intervention. To prepare the medication, based on the pharmacopoeia, more than 70% brix sugar syrup and concentrated coriander extract ingredient were used as base and as an active material, respectively. The essence was compounded of 82% linalool compound, 6% geraniol, 5% alphapynen, 3% betapynen and 1.48% thymol. To make placebo, more than 70% brix sugar syrup was used. To make color similar to the medication, standard oral bright yellow color with oral code 10894 (Magnolia Company; Iran) was used. The patients were asked to record their weekly headache symptoms over 4 weeks, in terms of headache duration based on hour and severity of each attack on a 10-score scale in the related checklist and present it to the physician. Those who were attacked by migraine more than one time in a week reported the mean duration and the mean severity of the attacks as the migraine symptoms of that week. The current random effects and longitudinal data transitions models were used to analyze data [26-28]. Therefore, two proposed models determining the clinical effectiveness of traditional medicine of the coriander fruit on the clinical course of patients with migraine were fitted, and according to the nature of the data, the best model was chosen based on the criterion of goodness of fit. … [29-36]
Findings by Text
Among 66 patients participating in the study, 51 patients (77.3%) were female and 15 patients (22.7%) were male. The mean age in intervention group was 33.09 ± 7.50years, and it was 31.3 ± 7.20years in control group (Table 1). Before the intervention, patients in the intervention group had more severe and longer attacks compared to control group. After starting the intervention, and over time, the intensity and duration of attacks decreased in both groups, but the reduction was significantly greater in the intervention group (Table 2). Random effects and transitions models showed different significances and coefficients. The results of the transfer model about the intensity of attacks and random effects model about the duration of the attacks indicated significant differences in the symptoms between the groups. The results of both models showed that the intervention group lost in average 4.27hours pain than control group. The mean of pain intensity in the patients in the intervention group lost in average 2.81 units (from 10) than control group. The duration and severity of attacks for each patient was dependent on the duration and severity of previous attack, respectively; that is to say the longer and more severe previous attack on anyone, the longer and more severe would be his current attack. Based on the criterion for selecting AIC model, transfer model (Markov) had the minimum AIC for the duration and severity of attacks and could be considered as the best option for the fitness of model. This model could introduce the relationship between the duration and severity of migraine attacks over time better than the other models. Therefore, considering the duration and severity of attacks in the previous measurement in the model, it is important and it is better to investigate the correlation of data by taking into the account the steps already taken.
Main comparison to the similar studies
Plants such as lavender, coriander and chamomile reduce nitric oxide production and thus reduce the migraine attacks [17]. Anti-inflammatory and analgesic effects of coriander extract in mice have been shown [18, 19, 22]. Coriander products can improve sleep [37, 38]. The severity and duration of migraines in the intervention group consumed the coriander fruit syrup significantly decreased. This result is consistent with similar studies. … [39, 40]
Suggestions
Due to chronic nature of migraine headaches, studies with longer duration and follow-up may offer better results. Fitting a model that reflects both the true spread and explicit transmission of data can better describe the effects of the intervention.
Limitations
Short duration of the intervention and follow-up was of the limitations of this study.
Conclusions
As a preventive treatment, coriander fruits are effective on migraine severity and duration reduction. In addition, to predict the current situation, the duration and severity of previous migraine attacks are necessary to be considered.
Acknowledgments
Staff of Paramedical School and Research Center of Shahid Beheshti University of Medical Sciences is appreciated.
Conflict of interest
There was no conflict of interest for the authors.
Ethical Permissions
The main plan was confirmed by Ethics Committee for Medical Studies of Shaid Beheshti University of Medical Sciences and it was registered by IRCT with register number IRCT2012122511876N.
Funding Sources
The study was funded by Shaid Beheshti University of Medical Sciences.

TABLES and CHARTS

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