@2024 Afarand., IRAN
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(3):201-206
ISSN: 2252-0805 The Horizon of Medical Sciences 2017;23(3):201-206
Comparison of Alexithymia and Impulsive Behaviors in Schizophrenia Patients and Healthy Individuals
ARTICLE INFO
Article Type
Descriptive & Survey StudyAuthors
Habibi Kaleybar R. (1)Mohammadzadegan R. (* )
Afi E. (2)
(* ) Psychology Department, Educational Sciences & Psychology Faculty, Azerbayjan Shahid Madani University, Tabriz, Iran
(1) Psychology Department, Educational Sciences & Psychology Faculty, Azerbayjan Shahid Madani University, Tabriz, Iran
(2) Psychology Department, Educational Sciences & Psychology Faculty, Tabriz University, Tabriz, Iran
Correspondence
Address: Shahid Madani University of Azerbaijan, Maragheh, 35km to Tabriz Road, Tabriz, East Azarbaijan Province, IranPhone: +98 (44) 36338394
Fax: +98 (41) z41492341
reza.moh1@gmail.com
Article History
Received: November 4, 2016Accepted: April 18, 2017
ePublished: July 22, 2017
BRIEF TEXT
Alexithymia refers to a defect in identification, processing, and emotional expression. This phenomenon was first reported in patients with a coronary disorder [1].
… [2-19]. Extensive literature in the healthy population and in patients with schizophrenia considers that impulsivity plays a key role in the risk of aggression and violence [20, 21], suicidal behaviors [22, 23], and the growth and maintenance of drug dependence [24]. In this regard, Anticot et al. [25] suggested that schizophrenic patients exhibit higher impulsivity in inhibiting the response. The study of Zornitsky et al. [26] with respect to excitement, lack of social pleasure and impulsivity in both schizophrenic patient who use opioids and non-addicts suggest a significant level of impulsivity in schizophrenic patients, both in the opium and non-drug users groups compared to the normal people. Dorson et al. [27] and Kalajin et al. [28], also, in their studies showed that schizophrenic patients exhibit higher impulsivity than normal subjects.
The main purpose of the present study was to compare the aspects of alexithymia and impulsive behaviors in patients with schizophrenia and normal people.
This is a causal-comparative study.
This study was conducted in 2016 on male patients with schizophrenia disorder admitted to Razi Psychiatric Hospital in Tabriz.
30 subjects were selected by simple random sampling and were matched to some of the students of Tabriz University who were selected by some demographic variables such as age and marital status. … [29].
The research tool was Toronto Alexithymia and Barratt Impulsiveness Scales. Toronto Alexithymia Scale (TAS-20): This scale is a 20-question test and three subscales; difficulty in identifying feelings (with 7 items), difficulty in describing feelings (with 5 questions), and externally-oriented feelings (with 8 items) are measured in five-degree Likert scale from the score one (totally disagree) to score 5 (totally agree). A total score is also calculated from the sum of the scores for the three subscales for total alexithymia. In the Persian version of the Toronto Alexithymia Scale [30], Cronbach's Alpha Coefficients for the total alexithymia and the three subscales of difficulty in identifying emotions, difficulty in emotional recognition and external thinking orientation were 0.85, 0.82, 0.75, and 0.72 respectively which is a sign of good internal consistency. The concurrent validity of this scale has been studied and confirmed based on the correlation among the subscales of this test and scale of emotional intelligence, psychological well-being and psychological distress [30]. Barratt Impulsiveness Scale (11th edition): this questionnaire is a 30-question test by Professor Ernest Barrett [19]. The structure of the questionnaire represents the dimensions of hasty decision, and lack of foresight that evaluate three factors of cognitive impulsivity, motor impulsivity, and lack of openness. Also, a total score for impulsivity is obtained from the sum of the triplets. This scale has been developed in the form of four alternatives and the highest score is 120 [19] The results of the research indicated that there were three factors with the names of: lack of planning, motor impulsivity, and cognitive impulsivity. The convergent validity of this questionnaire was verified by calculating its subscale correlation coefficient and the total validity of the impulsivity questionnaire was analyzed by Cronbach's alpha and retest that were 0.81 and 0.77 respectively[19]. Statistical analysis: Data were analyzed using SPSS 20 software. To compare the mean age in the two groups, independent t-test, and to compare the marital status of the two groups, Chi-square test were used; to compare the mean scores of the variables in the two groups, multivariate analysis of variance (MANOVA) and LSD post hoc test were used. At first, Kolmogorov-Smirnov test was used to check the normal distribution of data that in some of the variables related to the groups, the assumption of normalization was violated and the normality condition was not used for data analysis with parametric tests. Nevertheless, given that parametric tests are somewhat resistant to some minor violations of normalization, if the skewness is not a large distribution, one can still use parametric tests without worry. In these conditions, the increase in the type-1 error due to the normalization is very small and can be ignored [31]. Also, the homogeneity of variances was determined by the levene test. Wilkes Landa Test also allowed the use of multivariate analysis of variance and showed that there was a significant difference between the mean scores of both groups of schizophrenic patients and normal individuals in terms of at least one of the variables under study. The multivariate analysis of variance (ANOVA) and the LSD post hoc test were used to compare the means of the two groups in the above variables.
The mean age in schizophrenic patients was 27.30±2.60 and 28.50±2.30 years in the schizophrenic and normal population respectively. In terms of marital status, 14 (46.7%) and 16 (53.3%) were single and married respectively in schizophrenic patients, and 10 (33.3%) and 20 (66.7%) were single and married respectively in normal people group respectively. There was no significant difference between the two groups in terms of demographic variables and were completely peer (p>0.05). There was a significant difference between the mean scores of the schizophrenic group and the normal population in the variable of alexithymia and its components including the difficulty in the description of feeling, difficulty in identifying feelings, and externally oriented feeling subscale as well as in the variable of impulsive behaviors and its components include cognitive impulsivity, motor impulsivity and lack of openness and schizophrenic patients had higher scores in all variables than in the normal group (Table 1).
The results showed that schizophrenic patients had higher scores than normal people that this finding is consisted with the findings of Aras et al. [11], Doveau et al. [12], Hiri et al. [15], Caster et al. [13], and Zuckerman [17]. …[38-44].
Future research should investigate the underlying alexithymia and impulsive behaviors along with other suggested causes of pathology of this disorder.
The lack of control of some of the intervening variables (such as consumable drugs, severity and duration of the disease) due to the respective nature of the study and implementation on male patients to control the gender effect were among the limitations of this research.
Schizophrenic patients show high levels of alexithymia and impulsive behaviors compared to normal people.
All the staff and patients of the Razi Psychiatric Hospital in Tabriz who helped us with this research are sincerely appreciated.
Non-declared
In order to observe the ethics of research, first, the consent form for the project in terms of scientific and ethical issues was distributed among the participants at the time of implementation so that the participants would complete it if they wish to participate in the research for the satisfaction. In this form, while referring to the privacy issues of patients, it was stipulated that participants had the right to terminate their collaboration with the researcher at each stage of the research, according to their willingness.
All research costs have been provided by the authors.
TABLES and CHARTS
Show attach fileCITIATION LINKS
[1]Irani Barghi Z, Bakhti M, Baghyan MJ, Karami S. The relationship between the five factors of personality and alexithymia with mental health in MS patients. Sci J Manag Sys. 2014;3(10):64-79. [Persian]
[2]Taylor GJ, Parker JD, Bagby RM, Bourke MP. Relationships between alexithymia and psychological characteristics associated with eating disorders. J Psychosom Res. 1996;(41):561-8.
[3]Heshmati R, Ghorbani N, Rostami R, Ahmadi M, Akhavan H. Comparative study of alexithymia in patients with psychotic disorders, non psychotic and normal people. Sci J Hamadan Univ Med Sci. 2010;17(1):56-61. [Persian]
[4]Aleman A, Kahn RS. Strange feelings: Do amygdala abnormalities dysregulate the emotional brain in schizophrenia?. Prog Neurobiol. 2005;77(5):283-98.
[5]Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry. 2003;54(5):515-28.
[6]van Rijn S, Aleman A, Swaab H, Kahn RS. Neurobiology of emotion and high risk for schizophrenia: Role of the amygdala and the x-chromosome. Neurosci Biobehav. 2005;29(3):385-97.
[7]van 'T Wout M, Aleman A, Bermond B, Kahn RS. No words for feelings: Alexithymia in schizophrenia patients and first-degree relatives. Compr Psychiatry. 2007;48(1):27-33.
[8]Stanghellini G, Ricca V. Alexithymia and schizophrenias. Psychopathol. 1995;28(5):263-72.
[9]Cedro A, Kokoszka A, Popiel A, Narkiewicz-Jodko W. Alexithymia in schizophrenia: An exploratory study. Psychol Rep. 2001;89(1):95-8.
[10]Todarello O, Porcelli P, Grilletti F, Bellomo A. Is alexithymia related to negative symptoms of schizophrenia?. Psychopathology. 2005;38(6):310-4.
[11]Ersche KD, Turton AJ, Pradhan S, Bullmore ET, Robbins TW. Drug addiction endopheno types: Impulsive versus sensation-seeking personality traits. Biol Psychiatry. 2010;68(8):770-3.
[12]Duva SM, Silverstein SM, Spiga R. Impulsivity and risk-taking in co-occurring psychotic disorders and substance abuse. Psychiatry Res. 2011;186(2-3):351-5.
[13]Kester HM, Sevy S, Yechiam E, Burdick KE, Cervellione KL, Kumra S. Decision-making impairments in adolescents with early-onset schizophrenia. Schizophr Res. 2006;1(3):113-23.
[14]Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. Am J Psychiatry. 2001;158(11):1783-93.
[15]Heerey EA, Robinson BM, Mcmahon RP, Gold JM. Delay discounting in schizophrenia. Cogn Neuropsychiatry. 2007;12(3):213-21.
[16]Nolan KA, D'Angelo D, Hoptman MJ. Self-report and laboratory measures of impulsivity in patients with schizophrenia or schizoaffective disorder and healthy controls. Psychiatry Res. 2011;187(1-2):301-3.
[17]Zuckerman M. P-impulsive sensation seeking and its behavioral, psychophysiological, and biochemical correlates. Neuropsychobiology. 1993;28(1-2):30-6.
[18]Kirby KN, Finch JC. The hierarchical structure of self-reported impulsivity. Pers Individ Dif. 2010;48(6):704-13.
[19]Barratt ES, Stanford MS, Kent TA, Felthous AR. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry. 1997;41(10):1045-61.
[20]Quanbeck CD, Mcdermott BE, Lam J, Eisenstark H, Sokolov G, Scott CL. Categorization of aggressive acts committed by chronically assaultive state hospital patients. Psychiatr Serv. 2007;58(4):521-8.
[21]Volavka J, Citrome L. Heterogeneity of violence in schizophrenia and implications for long-term treatment. Int J Clin Pract. 2008;62(8):1237-45.
[22]Iancu I, Bodner E, Roitman S, Piccone Sapir A, Poreh A, Kotler M. Impulsivity, aggression and suicide risk among male schizophrenia patients. Psychopathology. 2010;43(4):223-9.
[23]Gut-Fayand A, Dervaux A, Olié JP, Lôo H, Poirier MF, Krebs MO. Substance abuse and suicidality in schizophrenia: A common risk factor linked to impulsivity. Psychiatry Res. 2001;102(1):65-72.
[24]Krishnan-Sarin S, Reynolds B, Duhig AM, Smith A, Liss T, Mcfetridge A, Et Al. Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers. Drug Alcohol Depend. 2007;88(1):79-82.
[25]Enticott PG, Ogloff JR, Bradshaw JL. Response inhibition and impulsivity in schizophrenia. Psychiatry Res. 2008;157(1-3):251-4.
[26]Zhornitsky S, Rizkallah E, Pampoulova T, Chiasson JP, Lipp O, Stip E, et al. Sensation-seeking, social a hedonia, and impulsivity in substance use disorder patients with and without schizophrenia and in non-abusing schizophrenia patients. Psychiatry Res. 2012;200(2-3):237-41.
[27]Dursun SM, Szemis A, Andrews H, Whitaker P, Reveley MA. Effects of clozapine and typical antipsychotic drugs on plasma 5-ht turnover and impulsivity in patients with schizophrenia: A cross-sectional study. J Psychiatry Neurosci. 2000;25(4):347-52.
[28]Kaladjian A, Jeanningros R, Azorin JM, Anton JL, Mazzola-Pomietto P. Impulsivity and neural correlates of response inhibition in schizophrenia. Psychol Med. 2011;41(2):291-9.
[29]Mesrabadi J, Alilou A. Effectiveness of conceptual map on retention and understanding and application of science concepts. Educ Psychol. 2016;12(40):151-71. [Persian]
[30]Besharat MA. Assessing reliability and validity of the Farsi version of the Toronto alexithymia scale in a sample of substance-using patients. Psychological Rep. 2008;102(1):209-20.
[31]Mesrabadi J, Jafariyan S, Ostovar N. Discriminative and construct validity of meaning in life questionnaire for Iranian students. Journal of Behavioral Sciences. 2013;7(1):83-90. [Persian]
[32]Higgins ET. Self-discrepancy: A theory relating self and affect. Psychol Rev. 1987;94(3):319-40.
[33]Kring AM, Neale JM. Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion?. J Abnorm Psychol. 1996;105(2):249-57.
[34]Gur RE, Kohler CG, Ragland JD, Siegel SJ, Lesko K, Bilker WB, Gur RC. Flat affect in schizophrenia: Relation to emotion processing and neurocognitive measures. Schizophr Bull. 2006;32(2):279-87.
[35]Carpenter WT Jr. Clinical constructs and therapeutic discovery. Schizophr Res. 2004;72(1):69-73.
[36]Larsen JK, Brand N, Bermond B, Hijman R. Cognitive and emotional characteristics of alexithymia: A review of neurobiological studies. J Psychosom Res. 2003;54(6):533-41.
[37]Aleman A. Feelings you can’t imagine: Towards a cognitive neuroscience of alexithymia. Trends Cogn Sci. 2005;9(12):553-5.
[38]Maro CJ, Angelo DD, Hoptman MJ. Olfactory identification, impulsivity, and aggression in schizophrenia. Schizophr Res. 2008;102(1-3):177-8.
[39]Hoptman MJ, Ardekani BA, Butler PD, Nierenberg J, Javitt DC, Lim KO. DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis. Neuroreport. 2004;(15):2467-70.
[40]Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO. Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study. Biol Psychiatry. 2002;52(1):9-14.
[41]Cheung AM, Mitsis EM, Halperin JM. The relationship of behavioural inhibition to executive functions in young adults. J Clin Exp Neuropsychol. 2004;26(3):393-404.
[42]Convit A, Douyon R, Yates K, Smith G, Volavka J, Czobor P, et al. Fronto-temporal abnormalities in violence. In: Stoff D, Cairns R, editors. Aggression and violence: Gnetic, neurobiological, and biosocial perspectives. Hillside, NJ: Lawrence Erlbaum Associates; 1996. pp. 169-94.
[43]Amore M, Menchetti M, Tonti C, Scarlatti F, Lundgren E, Esposito W, et al. Predictors of violent behavior among acute psychiatric patients: Clinical study. Psychiatry Clin Neurosci. 2008;62(3):247-55.
[44]Volavka J. The neurobiology of violence: An update. J Neuropsychiatry Clin Neurosci. 1999;11(3):307-14.
[2]Taylor GJ, Parker JD, Bagby RM, Bourke MP. Relationships between alexithymia and psychological characteristics associated with eating disorders. J Psychosom Res. 1996;(41):561-8.
[3]Heshmati R, Ghorbani N, Rostami R, Ahmadi M, Akhavan H. Comparative study of alexithymia in patients with psychotic disorders, non psychotic and normal people. Sci J Hamadan Univ Med Sci. 2010;17(1):56-61. [Persian]
[4]Aleman A, Kahn RS. Strange feelings: Do amygdala abnormalities dysregulate the emotional brain in schizophrenia?. Prog Neurobiol. 2005;77(5):283-98.
[5]Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry. 2003;54(5):515-28.
[6]van Rijn S, Aleman A, Swaab H, Kahn RS. Neurobiology of emotion and high risk for schizophrenia: Role of the amygdala and the x-chromosome. Neurosci Biobehav. 2005;29(3):385-97.
[7]van 'T Wout M, Aleman A, Bermond B, Kahn RS. No words for feelings: Alexithymia in schizophrenia patients and first-degree relatives. Compr Psychiatry. 2007;48(1):27-33.
[8]Stanghellini G, Ricca V. Alexithymia and schizophrenias. Psychopathol. 1995;28(5):263-72.
[9]Cedro A, Kokoszka A, Popiel A, Narkiewicz-Jodko W. Alexithymia in schizophrenia: An exploratory study. Psychol Rep. 2001;89(1):95-8.
[10]Todarello O, Porcelli P, Grilletti F, Bellomo A. Is alexithymia related to negative symptoms of schizophrenia?. Psychopathology. 2005;38(6):310-4.
[11]Ersche KD, Turton AJ, Pradhan S, Bullmore ET, Robbins TW. Drug addiction endopheno types: Impulsive versus sensation-seeking personality traits. Biol Psychiatry. 2010;68(8):770-3.
[12]Duva SM, Silverstein SM, Spiga R. Impulsivity and risk-taking in co-occurring psychotic disorders and substance abuse. Psychiatry Res. 2011;186(2-3):351-5.
[13]Kester HM, Sevy S, Yechiam E, Burdick KE, Cervellione KL, Kumra S. Decision-making impairments in adolescents with early-onset schizophrenia. Schizophr Res. 2006;1(3):113-23.
[14]Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. Am J Psychiatry. 2001;158(11):1783-93.
[15]Heerey EA, Robinson BM, Mcmahon RP, Gold JM. Delay discounting in schizophrenia. Cogn Neuropsychiatry. 2007;12(3):213-21.
[16]Nolan KA, D'Angelo D, Hoptman MJ. Self-report and laboratory measures of impulsivity in patients with schizophrenia or schizoaffective disorder and healthy controls. Psychiatry Res. 2011;187(1-2):301-3.
[17]Zuckerman M. P-impulsive sensation seeking and its behavioral, psychophysiological, and biochemical correlates. Neuropsychobiology. 1993;28(1-2):30-6.
[18]Kirby KN, Finch JC. The hierarchical structure of self-reported impulsivity. Pers Individ Dif. 2010;48(6):704-13.
[19]Barratt ES, Stanford MS, Kent TA, Felthous AR. Neuropsychological and cognitive psychophysiological substrates of impulsive aggression. Biol Psychiatry. 1997;41(10):1045-61.
[20]Quanbeck CD, Mcdermott BE, Lam J, Eisenstark H, Sokolov G, Scott CL. Categorization of aggressive acts committed by chronically assaultive state hospital patients. Psychiatr Serv. 2007;58(4):521-8.
[21]Volavka J, Citrome L. Heterogeneity of violence in schizophrenia and implications for long-term treatment. Int J Clin Pract. 2008;62(8):1237-45.
[22]Iancu I, Bodner E, Roitman S, Piccone Sapir A, Poreh A, Kotler M. Impulsivity, aggression and suicide risk among male schizophrenia patients. Psychopathology. 2010;43(4):223-9.
[23]Gut-Fayand A, Dervaux A, Olié JP, Lôo H, Poirier MF, Krebs MO. Substance abuse and suicidality in schizophrenia: A common risk factor linked to impulsivity. Psychiatry Res. 2001;102(1):65-72.
[24]Krishnan-Sarin S, Reynolds B, Duhig AM, Smith A, Liss T, Mcfetridge A, Et Al. Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers. Drug Alcohol Depend. 2007;88(1):79-82.
[25]Enticott PG, Ogloff JR, Bradshaw JL. Response inhibition and impulsivity in schizophrenia. Psychiatry Res. 2008;157(1-3):251-4.
[26]Zhornitsky S, Rizkallah E, Pampoulova T, Chiasson JP, Lipp O, Stip E, et al. Sensation-seeking, social a hedonia, and impulsivity in substance use disorder patients with and without schizophrenia and in non-abusing schizophrenia patients. Psychiatry Res. 2012;200(2-3):237-41.
[27]Dursun SM, Szemis A, Andrews H, Whitaker P, Reveley MA. Effects of clozapine and typical antipsychotic drugs on plasma 5-ht turnover and impulsivity in patients with schizophrenia: A cross-sectional study. J Psychiatry Neurosci. 2000;25(4):347-52.
[28]Kaladjian A, Jeanningros R, Azorin JM, Anton JL, Mazzola-Pomietto P. Impulsivity and neural correlates of response inhibition in schizophrenia. Psychol Med. 2011;41(2):291-9.
[29]Mesrabadi J, Alilou A. Effectiveness of conceptual map on retention and understanding and application of science concepts. Educ Psychol. 2016;12(40):151-71. [Persian]
[30]Besharat MA. Assessing reliability and validity of the Farsi version of the Toronto alexithymia scale in a sample of substance-using patients. Psychological Rep. 2008;102(1):209-20.
[31]Mesrabadi J, Jafariyan S, Ostovar N. Discriminative and construct validity of meaning in life questionnaire for Iranian students. Journal of Behavioral Sciences. 2013;7(1):83-90. [Persian]
[32]Higgins ET. Self-discrepancy: A theory relating self and affect. Psychol Rev. 1987;94(3):319-40.
[33]Kring AM, Neale JM. Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion?. J Abnorm Psychol. 1996;105(2):249-57.
[34]Gur RE, Kohler CG, Ragland JD, Siegel SJ, Lesko K, Bilker WB, Gur RC. Flat affect in schizophrenia: Relation to emotion processing and neurocognitive measures. Schizophr Bull. 2006;32(2):279-87.
[35]Carpenter WT Jr. Clinical constructs and therapeutic discovery. Schizophr Res. 2004;72(1):69-73.
[36]Larsen JK, Brand N, Bermond B, Hijman R. Cognitive and emotional characteristics of alexithymia: A review of neurobiological studies. J Psychosom Res. 2003;54(6):533-41.
[37]Aleman A. Feelings you can’t imagine: Towards a cognitive neuroscience of alexithymia. Trends Cogn Sci. 2005;9(12):553-5.
[38]Maro CJ, Angelo DD, Hoptman MJ. Olfactory identification, impulsivity, and aggression in schizophrenia. Schizophr Res. 2008;102(1-3):177-8.
[39]Hoptman MJ, Ardekani BA, Butler PD, Nierenberg J, Javitt DC, Lim KO. DTI and impulsivity in schizophrenia: A first voxelwise correlational analysis. Neuroreport. 2004;(15):2467-70.
[40]Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO. Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study. Biol Psychiatry. 2002;52(1):9-14.
[41]Cheung AM, Mitsis EM, Halperin JM. The relationship of behavioural inhibition to executive functions in young adults. J Clin Exp Neuropsychol. 2004;26(3):393-404.
[42]Convit A, Douyon R, Yates K, Smith G, Volavka J, Czobor P, et al. Fronto-temporal abnormalities in violence. In: Stoff D, Cairns R, editors. Aggression and violence: Gnetic, neurobiological, and biosocial perspectives. Hillside, NJ: Lawrence Erlbaum Associates; 1996. pp. 169-94.
[43]Amore M, Menchetti M, Tonti C, Scarlatti F, Lundgren E, Esposito W, et al. Predictors of violent behavior among acute psychiatric patients: Clinical study. Psychiatry Clin Neurosci. 2008;62(3):247-55.
[44]Volavka J. The neurobiology of violence: An update. J Neuropsychiatry Clin Neurosci. 1999;11(3):307-14.